David Jones

Neuroscience, Cognitive and Behavioral Neurology, Complex Systems, AI, Alzheimer's and Multimodal Neuroimaging, content personal opinion

[David Jones @DavidJonesBrain]

1/
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@NaipMayo @MayoClinic #ENDAlz

[Mayo Clinic Neuro @MayoClinicNeuro]

Struggle to multitask? Try to avoid getting frustrated—that can make multitasking harder for your brain. @MayoClinic neurologist Dr. David T. Jones explains that people can multitask; it just requires practice.

@NBCNews | @DrDavidACox | @DavidJonesBrain https://t.co/Z9lySjEbxZ

[David Jones @DavidJonesBrain]

@PessoaBrain Would this be consistent with our proposed stochastic latent oscillatory diffusion model? We still use the terms encoding and decoding. https://t.co/e6D0zOcNbs

[Earl K. Miller @MillerLabMIT]

New results!
Theta rhythms flexibly routing information based on behavior and feedback, organizing local and long-range neural communication.

Theta gates and routes information in the frontal cortex
https://t.co/kPk4vmwwBZ
#neuroscience

[Earl K. Miller @MillerLabMIT]

Beta rhythms sending top-down feedback to refine perception.

Olfactory bulb-cortex oscillations encode perceived odor intensity rather than concentration
https://t.co/0jVLdftcxt
#neuroscience

[David Jones @DavidJonesBrain]

If we can connect these concepts to observations in clinical brain imaging we could make progress on delivering on the perpetual promise of clinical translation. Here are eigenbrains of degenerating human brains:

[Micah G. Allen @micahgallen]

A new atlas reveals that functional connectivity patterns in the human neocortex shift dramatically from birth through old age, organizing brain regions along three dominant axes: sensory-to-association, visual-to-somatosensory, and modulation-to-representation.
https://t.co/A4XyHA9Jpv

[David Jones @DavidJonesBrain]

The Stochastic Latent Oscillatory Diffusion model is a framework that is not baffled by this observation :)

[Earl K. Miller @MillerLabMIT]

The brain’s code seems to be in constant flux.
Neurons fire much more erratically than researchers thought.
https://t.co/mFSWUwFjdm
#neuroscience

[Earl K. Miller @MillerLabMIT]

The brain’s code seems to be in constant flux.
Neurons fire much more erratically than researchers thought.
https://t.co/mFSWUwFjdm
#neuroscience

[Earl K. Miller @MillerLabMIT]

A communication subspace relays context-dependent actions from human prefrontal to motor cortex
https://t.co/cpoyuOwJlL
#neuroscience

[CLaE @leafs_s]

PNAS

Traveling-wave transcranial alternating current stimulation (twtACS) causally links neural timing to cognitive function

This study developed a new brain stimulation method called traveling-wave transcranial alternating current stimulation (twtACS). Unlike conventional brain stimulation, twtACS creates electrical waves that move across the brain in a specific direction, similar to natural neural traveling waves.

The researchers showed that these artificial traveling waves could:

Change the timing of neural activity in the brain
Control how signals propagate across brain regions
Improve cognitive performance in humans depending on the direction of the wave

They confirmed these effects using:

Human intracranial recordings
Monkey neural recordings
Human behavioral experiments

The study suggests that traveling waves are not just correlated with cognition but may causally influence cognitive function. This introduces a new way to noninvasively manipulate brain communication and potentially treat neurological disorders.

https://t.co/FnOQwNlB30

[Chiang, Feng-Kuei 江峰逵 @fkchiang89]

Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex https://t.co/OfoY9owebL

[David Jones @DavidJonesBrain]

I feel this! 💯

[Liuba Papeo @ljuba_pi]

Studies seem to show that research is becoming less ‘disruptive’ of established ideas.
And this is a problem.
@Nature

[David Jones @DavidJonesBrain]

@sciqst It would help to have a framework for the physiology related to conscious experience and how that physiology also relates to Alzheimer’s disease. Our new model of hippocampal neocortical interactions outlined what such a framework could look like: https://t.co/e6D0zOcNbs

[David Jones @DavidJonesBrain]

Fits w/ consciousness in Dysexecutive Alzheimer’s: “Evidence of impaired executive functions are obtained by patient and/or informant reports in conjunction with formal evaluation of cognitive performance on mentally effortful tasks that require conscious active manipulation…”

[Trends in Cognitive Sciences @TrendsCognSci]

Awareness as the heart of working memory

Review by Richard Allen, Alan Baddeley, & Graham Hitch
https://t.co/65QeBSzRB4

[Earl K. Miller @MillerLabMIT]

The prefrontal cortex controls memory organization in the hippocampus
https://t.co/4HYMc9TKXs
#neuroscience

[Brain @Brain1878]

Corriveau-Lecavalier et al. show that patterns of default mode network dysfunction predict future conversion to amyloid positivity, mild cognitive impairment, and dementia, emphasizing the role of network dyshomeostasis in Alzheimer’s disease. https://t.co/B14bNHaYdf

[David Jones @DavidJonesBrain]

“…these results suggest that conscious access to memory relies on a separable set of neural mechanisms from those related to neural reinstatement/reactivation”. The aphantasia literature suggests this true for perceptual memory as well. Fits w/ SLOD’s 2 generative streams.

[Earl K. Miller @MillerLabMIT]

Consciousness is rhythmic.
Alpha oscillations track the projection of reactivated memories into conscious awareness
https://t.co/6YIj2JzBDp
#neuroscience

[Earl K. Miller @MillerLabMIT]

Consciousness is rhythmic.
Alpha oscillations track the projection of reactivated memories into conscious awareness
https://t.co/6YIj2JzBDp
#neuroscience

[Yuelin Shi @Yuelin_Shi]

Our paper is now out!
https://t.co/qn7xmgh82r
A big question:
1) Is IT cortex well described as a general-purpose feedforward DNN?
OR
2) Are face patches genuinely specialized for processing faces?
Read on to find out the answer. (1/N)

[David Jones @DavidJonesBrain]

A generative inference framework? Coarse-to-fine denoising, with early prior-dominated step (is this a face?) giving way to a data-dominated step (which face?). “DC subtraction” they describe is subtracting prior to expose posterior. Not just representing. Iteratively solving.

[nature @Nature]

Nature research paper: Rapid concerted switching of the neural code in the inferotemporal cortex

https://t.co/TX9kLP8fra

[David Jones @DavidJonesBrain]

@davideagleman @JRBneuropsiq This new framework has partial explanations for some of these mysteries and is directly tied to clinical reality (dementia) allowing for a robust and translational empiric program: https://t.co/ldapotfemA