David Tadres

[Pierre Apostolides @pfapostolides]

@MaxNigro_Neuro Pretty cool stuff. Reminds me of this paper in the retina. Non-monotonic tuning via depo block. https://t.co/2VNX42006w. What I wonder is if this kind of tuning is overlooked w calcium imaging. e.g., it would just look like highly non-linear tuning to extreme sensory parameters

[Maximiliano José Nigro @MaxNigro_Neuro]

This is so beautiful! Elegant study linking cellular biophysics and behavior.
What happens at the synapses of these neurons during depolarization block?
How does this mechanism interact with inhibitory circuits?

[David Tadres @DavidTadres]

@MaxNigro_Neuro I'd therefore speculate that in both cases no neurotransmitters are released.

This hypothesis of course needs to be tested.

[David Tadres @DavidTadres]

@MaxNigro_Neuro Since the loss of spiking due to loss of activation leads (the 2015 study) , and the loss of spiking due to depolarization block (current study) leads to the characteristic circling behavior, it seems the outcome for the animal is analogous.

[David Tadres @DavidTadres]

@drosophilosophy @tamsioul Thank you!

[Matthieu Louis @tamsioul]

[1/11] @DavidTadres and I are excited to share new research https://t.co/fskxPEDSti where we show that olfactory sensory neurons undergo silencing due to depolarization block at ethologically relevant odor concentrations. #olfaction #chemosensation #behavior

[Tim Mosca (he/him) @drosophilosophy]

making connections! @NufoTheFlyGuy talks about the outreach he and his lab did with mattheiu louis and david tadres bringing the PiVR system to high school students in chicago!! #cshlfly22

[Ibrahim Tastekin @TastekinIbrahim]

Very happy to be a part of this work. If you are doing functional connectivity experiments in Drosophila, beware of the leaky expression of optogenetic effectors that might lead to false positive signals in the neurons of which activity is recorded.

[Matthieu Louis @tamsioul]

[1/2] In functional connectomics, beware of potential artifacts due to effector leaks. In recent work with David Stern @TastekinIbrahim @DavidTadres, we document that false-positives can arise from the leaky expression of Chrimson: https://t.co/ysUxYzB2w8

[Matthieu Louis @tamsioul]

@openneurosci @DavidTadres @worldwideneuro @Raspberry_Pi [4/4] As part of the presentation, we hope to hear your feedback. We would like to know how this tool could be made better for your own use. We look forward to connecting with you on Sept 3 3pm UTC https://t.co/l9rzXdfPYw

[Matthieu Louis @tamsioul]

@openneurosci @DavidTadres @worldwideneuro @Raspberry_Pi [3/4] PiVR is highly versatile - it can be used for much more than the creation of virtual odor gradients. For instance, in 30 min PiVR can be adapted to convert the movement of a facsimile animal into a sound landscape by using a piezo (see video, crank up the volume).

[Matthieu Louis @tamsioul]

@openneurosci @DavidTadres @worldwideneuro [2/4] We will describe how PiVR works, why its high frame rate and short latency are important to create virtual realities, how to get started with it, and what is coming next with the availability of ever more powerful @Raspberry_Pi.

[Matthieu Louis @tamsioul]

@openneurosci @DavidTadres @worldwideneuro [1/4] Join us this Friday for our presentation of the PiVR closed-loop tracker (https://t.co/Vj7hN41JQP) @openneurosci. In this talk @davidtadres and I will discuss how PiVR can help break technical barriers in your science.

[Matthieu Louis @tamsioul]

"Fruit Flies Plug into the Matrix" https://t.co/TIW0EaqP7T: @sciam has published an article that describes the use of virtual realties in Drosophila and our PiVR tracker. @DavidTadres & I thank @sophiebushwick and @MaquiCll for decoding our work simply and with a stunning video.

[PLOS Biology @PLOSBiology]

Low-cost #VirtualReality for tiny animals! @DavidTadres & @tamsioul present Raspberry Pi VR (PiVR), designed to enable academic labs & #CitSci projects to explore the neural circuitry of behavior by immersing freely-moving animals in VR #PLOSBiology https://t.co/ZREBaY4wpw

[Tim Mosca (he/him) @drosophilosophy]

@tamsioul @DavidTadres this is amazing! congrats! i loved seeing these in action. i think i just found my new summer building project. :-)

[Robert Carrillo @NufoTheFlyGuy]

Great work by @DavidTadres and @tamsioul ! We have this tracker in the lab and works great :)