Dirk Benzinger

Postdoc at @TheCrick in the Briscoe Lab. Previously PhD student with @KhammashLab. Dynamic signaling, gene regulation, synthetic biology, and optogenetics.

[Dirk Benzinger @DbenzingerD]

Gaining a quantitative understanding of developmental processes requires spatiotemporal perturbations and measurements

This can be very challenging in vivo

We present an optogenetic in vitro system to gain insight into morphogen patterning dynamics

For more see James’ thread

[James Briscoe @briscoejames]

Our latest: a new optogenetic system for precise spatiotemporal control of gene expression

We use it to dissect the dynamics of Shh gradient formation & patterning

A thread 🧵

https://t.co/Ki4COIjVcl

[Dirk Benzinger @DbenzingerD]

@CDessauges Thanks a lot Coralie :)

[Dirk Benzinger @DbenzingerD]

Gaining a quantitative understanding of developmental processes requires spatiotemporal perturbations and measurements

This can be very challenging in vivo

We present an optogenetic in vitro system to gain insight into morphogen patterning dynamics

For more see James’ thread

[James Briscoe @briscoejames]

Our latest: a new optogenetic system for precise spatiotemporal control of gene expression

We use it to dissect the dynamics of Shh gradient formation & patterning

A thread 🧵

https://t.co/Ki4COIjVcl

[Dirk Benzinger @DbenzingerD]

Thanks to the whole Briscoe lab for their support! And also to many many more people @TheCrick who make this a great place to do science.

[Joaquina Delas @joadelas]

🚨 The Delas lab @LMCB_UCL is officially recruiting 🥳
We will study how cis-regulatory elements control developmental cell fate choice, focusing on gene silencing. Funded by Wellcome.

Postdoc advert closes on 12 March!

https://t.co/JA3zdNHuUT

[Giulia Boezio @Giulsboezio]

🚨Meeting alert!

Do you study cell lineages?
In development, cancer, growth, regeneration?

Join our @royalsociety meeting “Cell lineages across scales, space & time": barcoding, somatic tracing, imaging, modelling.
Submit abstract, engage with leading speakers & win prizes!

[Teresa Rayon @t_rayon]

🚨we’re looking for a Postdoc
(2-years initially) to develop a project on dev. tempo in mouse embryos 🐭 ⌛️

📩 drop an email for further info

Link: https://t.co/LaqsYlXefk

Closes Jan 31st

🔁Please RT

[Joaquina Delas @joadelas]

I am excited to share that I will be starting my lab at UCL as part of the LMCB @LMCB_UCL in 2024. We will be studying how cis-regulatory elements controls cell fate decisions during development. We are recruiting at all levels. Learn more and reach out!

[Rubén Pérez-Carrasco @2piruben]

🪧 Join our research group! We're looking for a postdoc interested in inference of cell competition strategies 🦠⚔️🦠using agent-based models and deep learning in collaboration @Tristan_AR. Do not hesitate to DM (and RT!)

[Andreas Milias-Argeitis @andreas_milias]

Please RT

We have an open PhD position in our group to study how growth regulators interact with the cell cycle. If you are interested, check the job ad to apply: https://t.co/uoS7XkCkv3. For any questions, feel free to contact me. Deadline is October 2nd.

[Dirk Benzinger @DbenzingerD]

@KhammashLab Congrats, Mustafa!

[Dirk Benzinger @DbenzingerD]

@katwrog @allison_saul_ @KhammashLab Great to see that you chose our paper for your Writing Club. It's a very nice summary @allison_saul_ :) The diamond DNA is great as well :D

[Katherine W. Rogers @katwrog]

@allison_saul_ explains how "Diamond IFFLs are a Signaling Decoder's Best Friend" in the latest UDS Writing Club post! Summary of a dazzling paper by @DbenzingerD & Serguei Ovinnikov in the @KhammashLab 💎 https://t.co/6HHEkGRBRb

[James Briscoe @briscoejames]

Our latest: Deep dynamical modelling of developmental trajectories with temporal transcriptomics

Experimental & computational methods for robust dynamical modelling of gene expression from single-cell transcriptomic data

A thread 🧵

https://t.co/51NdK3Kceo

[Mustafa Khammash @KhammashLab]

Optogenetic feedback control of the unfolded protein response (UPR) in yeast can significantly increase the yield of a difficult-to-fold protein. #synbio #optogenetics

https://t.co/S9UaMRs3NR

Credit to @moritzctsb and @DbenzingerD & thanks to @ETH_en @ETH_BSSE @ERC_Research

[Gregory Batt @gregory_batt]

Sebas' PhD paper on automated turbidostats and optogenetics, secretion sweetspots and secretory burnout state, and on cybergenetics has just been posted on bioRxiv! https://t.co/pX7uITwVwx
#labautomation, #optogenetics, #bioproduction, #synbio, #cybergenetics

[Mustafa Khammash @KhammashLab]

Cybergenetic control of the unfolded protein response optimizes protein production in yeast.

Pls. check out our bioRxiv preprint.
https://t.co/S13NaDTfmE
#synbio #cybergenetics

[Jake Cornwall-Scoones @jake_cs_]

Great to see our work on self-organisation in ETX in print. A huge pleasure contributing the modelling to this work with @Min_Bao_, Matt Thomson, @ZernickaGoetz and many others on this project during my time at Caltech

[Joaquina Delas @joadelas]

Come and work with us @TheCrick @briscoejames lab! Fixed-term Laboratory Research Officer (BSc or equivalent)

Fun project understanding how cis regulatory elements control cell fate decisions in spinal cord development

Closing 1st Aug! Please RT
https://t.co/EJ81wMGRku

[Joaquina Delas @joadelas]

First project in @briscoejames lab. We uncover two cis regulatory strategies used in neural progenitor cell fate choice.

It starts with the question: when you have one signal directing several alternative fates, what is the chromatin regulation strategy? https://t.co/W8IOCEJZTB

[jared toettcher @toettch]

it's great to see this out! feedforward loops are so powerful for building signal sensors & signal generators. some other examples: work from the Lahav lab on p53 decoding (https://t.co/90nvrUWeM6) and our biosensor for Erk pulses
(https://t.co/hgyCW7HYrV)