Decipher Analytics

Decipher Analytics is developing a fully integrated, health research informatics platform called a data commons.

[Decipher Analytics @DecipherAnalyt2]

Around 10,600 fewer breast cancer patients have started treatment in the last year in England

https://t.co/iYWISOXi0g

The majority of these ‘missing’ breast cancers are early stage disease, based on provisional data from Public Health England’s Rapid Cancer Registration data

[Decipher Analytics @DecipherAnalyt2]

Many studies have looked at the use of Metformin in a wide range of other disorders, including heart disease and cancer

https://t.co/x8QXYwD4HT

A recent study indicates that the drug might help prevent lung inflammation in patients with COVID-19

[Decipher Analytics @DecipherAnalyt2]

Polymerases were thought to only work in one direction, DNA into DNA or RNA. Researchers have shown that RNA segments can be written back into DNA.

https://t.co/OoToxLJ7X5
The study focused on polymerase theta, which seems most similar to viral reverse transcriptases.

[Decipher Analytics @DecipherAnalyt2]

The number of COVID cases has now reached ~ 170M, millions of people are experiencing persistent symptoms

https://t.co/IJf8IESqcm
Patient surveys have revealed an extensive list of symptoms, such as fatigue, dry cough, shortness of breath, headaches & muscle aches

[Decipher Analytics @DecipherAnalyt2]

BlueRock Therapeutics Parkinson’s disease stem cell therapy has started clinical studies. The first dose of DA01, pluripotent stem cell-derived dopaminergic neurons, was given out in a phase 1 test

https://t.co/JymLFxAw9x

[Decipher Analytics @DecipherAnalyt2]

Researchers have used a bespoke adenine base editor to correct the sickle cell mutation in patient blood stem cells & in mice

https://t.co/FWHqFf3kX6

They were able to correct the mutation without double-stranded DNA breaks or inserting new segments of DNA into the genome

[Decipher Analytics @DecipherAnalyt2]

New insights into skull-based immune cells could inspire treatments for brain disease

https://t.co/p9Rolh33Kx

Some immune cells originate in the skull & migrate to the meninges without passing through the bloodstream. These immune cells appear to shield the brain from disease

[Decipher Analytics @DecipherAnalyt2]

The BBC's Rory Cellan-Jones (.@ruskin147) discusses his diagnosis with Parkinson's disease and the trial that he is taking part in that may help with the diagnosis and treatment of the disease.

https://t.co/LX4Y7IqF0Q

[Decipher Analytics @DecipherAnalyt2]

Researchers have discovered a new & unique form of ALS

https://t.co/qfg4PcLtPb

A study reveals 2 major findings: a single genetic cause of early-onset ALS & a novel, metabolism-associated, molecular pathway that may contribute to neurodegeneration in other forms of the disease

[Decipher Analytics @DecipherAnalyt2]

Bristol Myers Squibb has expanded the indications for it's multiple sclerosis drug Zeposia, which has now been approved to treat ulcerative colitis
https://t.co/I4oON83kmv

[Decipher Analytics @DecipherAnalyt2]

Results from a series of experiments in mice & human neurons suggest that an ion channel protein TRPC5 represents important contributor to tactile and spontaneous hypersensitivity to pain after inflammation.

https://t.co/c3GGC5ExTe

[Decipher Analytics @DecipherAnalyt2]

Research funded by @CR_UK suggests that widely-used anti-inflammatory drugs make tumours in mice more responsive to treatments that harness the power of the body’s own immune system to tackle cancer

https://t.co/zaYLxXzzGs

[Decipher Analytics @DecipherAnalyt2]

A man who is blind has had glimmers of vision restored thanks to a high-tech treatment using optogenetics, which involves genetically altering nerve cells so they respond to light

https://t.co/VNBj38gRgg

[Decipher Analytics @DecipherAnalyt2]

A phase 2b trial of @NGMBio’ aldafermin in nonalcoholic steatohepatitis has missed its primary endpoint.

https://t.co/FIBZIjSVIe

After 24 weeks of daily injections, people on aldafermin performed no better than their peers on placebo against key measures

[Decipher Analytics @DecipherAnalyt2]

Researchers have developed self-organising heart organoids that could be effective injury and in vitro congenital disease models

https://t.co/pGvTxuzSc3

These cardioids have the potential to revolutionise research into cardiovascular disorders and malformations of the heart

[Decipher Analytics @DecipherAnalyt2]

Researchers have designed an experimental drug that reversed key symptoms of Alzheimer's disease in mice

https://t.co/fcubiBk0EC

The drug works by reinvigorating a cellular cleaning mechanism that gets rid of unwanted proteins by digesting & recycling them
#DementiaActionWeek

[Decipher Analytics @DecipherAnalyt2]

The development of dementia late in life is associated with abnormal blood levels of dozens of proteins up to 5 years earlier

https://t.co/tQjSf2VglY

Most of these proteins were not known to be linked to dementia before, suggesting new targets for prevention therapies

[Decipher Analytics @DecipherAnalyt2]

New insight into aggressive breast cancer could drive treatment choices

https://t.co/l2jMtJDnlf
Breast tumors that are both estrogen-receptor (ER)- and HER2-positive are typically slow-growing, while ER-negative, HER2-positive cancers are more aggressive

[Decipher Analytics @DecipherAnalyt2]

@biogen released the news that a gene therapy failed to improve vision in patients with X-linked retinitis pigmentosa

https://t.co/OmqUqxiYHD

It was testing the gene therapy in patients with the rare, inherited eye disease that causes progressive vision loss.

[Decipher Analytics @DecipherAnalyt2]

A major trial to that aimed to detect #OvarianCancer has failed to save lives

https://t.co/KWyYGohh9Y

Initial results were promising, with annual blood tests detecting cases of ovarian cancer earlier. However, the final results showed the screening had failed to save lives