UFDI researchers revisit the human endocrine pancreas histopathology during T1D development! https://t.co/psCCvzMYtF
Leveraging whole-slide scanned images from the nPOD repository and a semi-automated quantification pipeline, the study characterized the distribution of endocrine cells, cell clusters, and islets of different sizes within the pancreas parenchyma. Investigating 145 human pancreas samples at different stages of T1D development, Drotar et al. demonstrate that insulin-positive single cells, clusters, and small islets are lost before larger islets — with these changes already detectable in multiple autoantibody-positive donors. @AmDiabetesAssn@DeniseDrotar@BruskoMaigan@matkinsonT1D