Derek Chan

PhD McMaster University - siderophores, antibiotics, Trojan horse, TonB-dependent transporters

[Lori L. Burrows @Dr_Lori_Burrows]

Congratulations Dr. ⁦@DerekCKChan1⁩ on a stellar defence on your #TBDT work. Thanks to external ⁦@CMKhursigara⁩ for zooming on his vacation and ⁦@gerryiidr⁩ and Marie Elliot for wide ranging questions. We'll miss you Iron Man!! Best of luck with your new gig 😊

[Lori L. Burrows @Dr_Lori_Burrows]

Big congratulations to PhD candidate ⁦⁦@veronicantran⁩ for winning a Beveridge poster award ⁦@CSM2023_Halifax⁩ for her work on mechanisms of resistance to T4P-specific #phages 🏆🎉!

[Lori L. Burrows @Dr_Lori_Burrows]

Poster power @CSM2023⁦@CSM2023_Halifax⁩ ! If you missed these, or the one on FimX-marks-the-spot that Nathan Roberge presented on Monday, track these awesome students down and ask them about their cool science 🧫 🔬⁦@veronicantran⁩ ⁦@DerekCKChan1⁩ #Pseudomonas

[Lori L. Burrows @Dr_Lori_Burrows]

Did you know that #vancomycin can kill #Pseudomonas? Read all about it in our newest paper from @DerekCKChan1 with his fearless undergrads Mahrukh and Katherine, fellow PhD candidate Ikram, and lab manager Hanjeong. @McMasterIIDR @BBS_McMasterU 1/6 🧵 https://t.co/EUKViZ6Txo

[Lori L. Burrows @Dr_Lori_Burrows]

This study will use the SURFAR platform developed by @DerekCKChan1 to identify the TonB-dependent transporters used by this new conjugate molecule - developed by @brent_s_weber - to enter and kill #Pseudomonas

[Global Nexus @MacGlobalNexus]

Researchers in @Dr_Lori_Burrows' lab are using "Trojan horse" tactics to trick bacteria into letting antibiotics in. This research, published recently in @PNASNews, could lead to new ways to treat drug-resistant infections. #AMR @DerekCKChan1 @machealthsci
https://t.co/STRN7dsMVl

[McMaster University @McMasterU]

How a ‘Trojan horse’ approach to tricking drug-resistant bacteria could lead to new ways to treat infections | @machealthsci @MacGlobalNexus @McMasterIIDR https://t.co/qk95Fl22GV

[McMaster Health Sciences @machealthsci]

It’s a ‘Trojan horse’ approach to tricking bacteria into letting antibiotics in," says @Dr_Lori_Burrows, a professor @BBS_McMasterU @McMasterU. #HamOnt https://t.co/YyN164cu0k

[Paul Hoskisson 😷🔬🧫🧬🐸🐍🦎 @PaulHoskisson]

This is really cool from @Dr_Lori_Burrows lab - Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction https://t.co/A99WLvlncN

[Kesha Josts @KJosts]

Really happy to have contributed to this amazing work!

[Zach Reitz @ZachReitzPhD]

Come for the crystal structures, stay for the implications for Trojan horse antibiotics. A beautiful and thorough study!

[Derek Chan @DerekCKChan1]

@pogonogo @Dr_Lori_Burrows @KJosts @gerryiidr Thank you!

[Lori L. Burrows @Dr_Lori_Burrows]

🔥🔥 The latest from @DerekCKChan1 and @KJosts from the Tidow lab, with help from Kalinka Koteva and @gerryiidr - Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction 1/10
https://t.co/IlHrvlOFzT

[Lori L. Burrows @Dr_Lori_Burrows]

Cool new story from @DerekCKChan1 with his @BBS_McMasterU thesis students Katherine Dykema & Mahrukh Fatima, with #phage contributions from Ikram Qaderi & Hanjeong Harvey. Thread (1/10).

Nutrient Limitation Sensitizes #Pseudomonas aeruginosa to Vancomycin https://t.co/5jadgca82O

[Lori L. Burrows @Dr_Lori_Burrows]

Thanks for highlighting the nice work of PhD candidate ⁦@DerekCKChan1⁩ on Trojan horse antibiotics that hijack TonB-dependent transporters!

Illuminating Siderophore Transporter Functionality with Thiopeptide Antibiotics #AMR ⁦@McMasterIIDR⁩ https://t.co/1peC79aopw

[Lori L. Burrows @Dr_Lori_Burrows]

A fascinating look at TBDTs from PhD candidate @DerekCKChan1! Why make your own #siderophores when you can just steal your neighbours'? #Pseudomonas aeruginosa FpvB Is a High-Affinity Transporter for Xenosiderophores Ferrichrome and Ferrioxamine B | mBio https://t.co/UpofCACmsj

[Derek Chan @DerekCKChan1]

@Dr_Lori_Burrows Would be cool if phage came out!

[Lori L. Burrows @Dr_Lori_Burrows]

Just in time for World Antibiotic Awareness Week #WAAW - new work from the amazing @DerekCKChan1, a great collaboration with Inokentijs (Kesha) Josts & Henning Tidow (Hamburg) and Kalinka Koteva & @gerryIIDR (McMaster)! https://t.co/vmEHLbGSSH 🧵1/5

[Derek Chan @DerekCKChan1]

@ZachReitzPhD @Dr_Lori_Burrows I wouldn’t trust results from docking alone. There are also other docking programs that may give a different prediction so experimental validation is still important 🙂

[Derek Chan @DerekCKChan1]

@ZachReitzPhD @Dr_Lori_Burrows The orientation of the molecules may not be correct but it gives us a rough idea of where they might bind in the transporter, which we can then test.