Real world data presented by @krchhabra group at #ASMBS2025
Weight loss after 2 years:
✴️ Gastric bypass: 26%
✴️ Sleeve gastrectomy: 23%
✴️ Tirzepatide: 8%
✴️ Semaglutide: 5%
@EzraTeitelbaum I counted 9 but one or two could be due to slow filling of duodenum. Would try glucagon and another power flush. 68 looks like a diverticulum possibly type III
🏆 Tirzepatide vs. Semaglutide
The heavyweight bout we’ve all been waiting for—and it’s a TKO.
- - -
A new NEJM study just dropped the first head-to-head trial in people with obesity (no diabetes).
Here’s how it played out over 72 weeks:
🥇 Tirzepatide (Zepbound) vs 🥈 Semaglutide (Wegovy)
🔹 –20.2% vs –13.7% weight loss → 47% greater relative reduction
🔹 20% on tirzepatide lost ≥30% of their body weight (triple the semaglutide rate!)
🔹 Waistline: –18.4 cm vs –13.0 cm
🔹 Sex matters: women in both arms lost ~6% more than men
📉 Responder rates (tirzepatide vs semaglutide):
✅ ≥10% loss: 81.6% vs 60.5%
✅ ≥15% loss: 64.6% vs 40.1%
✅ ≥20% loss: 48.4% vs 27.3%
✅ ≥25% loss: 31.6% vs 16.1%
⚠️ Side effects?
Mostly GI. Mostly manageable. No new red flags.
Bottom line:
This isn’t incremental—it’s transformational.
GLP-1 was the revolution. Tirzepatide is the next frontier.
Let’s talk:
Access. Equity. Long-term outcomes.
Are formularies ready for this future?
🔗 Full NEJM study: https://t.co/463akhNp1K
#Zepbound #Wegovy #Tirzepatide #Semaglutide #ObesityMedicine #GLP1 #GIP #NEJM #WeightLoss #HealthTech #DigitalHealth #MedTwitter h/t @scottisaacsmd for images.
POV You’re a med student driving the lap scope for the first time
Your attending: “The horizon still isn't straight”
You *panics in sunset 🌇🌇*
This @BehindTheKnife video might help 👇
ENDOSURGERY #2: ENDOBARIATRICS
Did you know you can do a sleeve with an endoscope? How cool is that 🕶️??! Find out if it is all it's cracked up to be + watch some great footage 📹 👇🏼
https://t.co/qmEOlpuoHz
Great work from our endosurgery team @SAyusoMD@CraftsTrevor@UjikiMike@briandunkinmd
Great talk by Dr. Matthew Ballweg this morning on the role of hand assisted MIS techniques for elective #diverticulitis with lower rates of ostomy formation and decreased operating time #SWSC25#MIS
Difference of Bariatric surgery versus medical management for prevention of diabetes in patients with obesity (15 year follow up) @LdePinaCV great work 👏🏽