Douglas Instruments

Design, manufacture and sell the versatile and reliable Oryx range of robots for automatic protein crystallization. #cryoEM #proteincrystallization #microED

[Douglas Instruments @DougInstruments]

Unlock the power of the metastable zone! The following tools allow nucleation and crystal growth to be separated and precisely controlled.

rMMS Microseeding

Get new hits in different conditions, different morphologies and better-diffracting crystals by adding seed stock to a random screen.

https://t.co/WlsL5BpvOO

Phase diagram optimization

Improve initial hits and know precisely where the metastable zone sits for your crystallization condition.

https://t.co/yEVKdpHCPf

Seedstock optimization

Fine tune your seed stock and add it to metastable conditions to get the right size and number of crystals for your project.

https://t.co/cDoVwqtQKT

[Douglas Instruments @DougInstruments]

New in IUCrJ: Automated microbatch-under-oil phase diagrams to rationalize serial crystallography sample preparation
Open access: https://t.co/OALMFWeded

Douglas Instruments has collaborated with the University of Southampton and Diamond Light Source to develop a fast and very simple method to generate phase diagrams of your proteins, which in practice often look very different from the “classical” phase diagrams that appear in textbooks.

Sample Preparation Workflow:
1️⃣ Random screening
2️⃣ rMMS with seeding
3️⃣ Optimization, additive screens or 2D grids
4️⃣ Broad phase diagram mapping
5️⃣ Zoom and tune seed dilution for crystal size and number control

#proteincrystallography #serialcrystallography #rMMS #microseeding #phasediagrams

[IUCrJ @IUCrJ]

Jack Stubbs et al.: Automated microbatch-under-oil phase diagrams to rationalize serial crystallography sample preparation #SerialCrystallography #SamplePreparation #PhaseDiagrams @unisouthampton @uniofexeter... #IUCr https://t.co/0qoCWYAW7Z

[Jack Stubbs @serialstubbs]

I'm excited to share my PhD research, now published in @IUCrJ: "Automated microbatch-under-oil phase diagrams to rationalize serial crystallography sample preparation" 💎🔬✨
https://t.co/9NIaeNY7pK

In serial crystallography, the biggest bottleneck is preparing the crystals!

[Javier M. Gonzalez @_biojmg]

🤩 Muy contentos con esta nueva adquisición. Thank you @DougInstruments !!
#REPARA #CONICET
El INBIONATEC adquiere el primer robot OryxNano de Argentina para impulsar las investigaciones en estructura molecular de enzimas https://t.co/ztNk3OSG1U

[Cécile Exertier, PhD @CecileExertier]

⚡It has been two exhausting but fulfilling weeks of training at the CNR-IBPM in Rome on advanced protein crystallization and surface plasmon resonance with talented early stage researchers from all over Europe.⚡

A huge thank you to @PatrickSSte from @DougInstruments!

@ItacaSB

[Douglas Instruments @DougInstruments]

An excellent talk by @serialstubbs at #SWSBC 2025 on Droplet Microfluidics for Uniform Micro-crystallization and Rapid Mixing - which included some slides on automatic phase diagram optimisation. https://t.co/AOy2psYjes

[Douglas Instruments @DougInstruments]

Visit our booth and poster presentation at the #ACA2025 meeting.
Pick up a free microseeding toolkit and find out about our new automatic phase diagram optimization experiments. #Crystals #ProteinCrystallization #Microseeding

Click below to see a preview PDF of our poster and be sure to stop by to discuss the methods and results in more detail. https://t.co/er8CukvbWV

[Douglas Instruments @DougInstruments]

Want to set up a complete protein phase diagram in minutes? 🧪
Oryx robots + microbatch-under-oil = high-speed, high-clarity crystallization.
Watch it in action: https://t.co/kVpNp7Gqbr
#StructuralBiology #ProteinCrystallization

[Douglas Instruments @DougInstruments]

What’s your go-to crystallization method?
🧪 Hanging Drop
🧪 Sitting Drop
🧪 LCP
🧪 Microbatch-under-oil
We’re curious—and happy to help you optimise it with Oryx automation!
2nd chance to join the Phase Diargram webinar.
7th May @2pm BST
📷Register:  https://t.co/W7sZvQ2G2G
#StructuralBiology #ProteinCrystallization

[Jack Stubbs @serialstubbs]

My first 1st author paper is now published - Droplet microfluidics for time-resolved serial crystallography @unisouthampton @serialstubbs @SoCoBioDtp @DiamondLightSou @esrfsynchrotron @sotonbiosci @IUCrJ #DropletMicrofluidics #Micromixing https://t.co/20Qs7lNzph

[Douglas Instruments @DougInstruments]

📍 At the BCA Conference this week? Pop by and say hi to Stefan from DI

He’ll be happy to chat about all things protein crystallization — and why our Oryx robots are a game-changer for rapid phase diagram setup 🔬✨

💻 Can’t make it? Join our webinar on 7th May for a live demo! https://t.co/W7sZvQ2G2G
📩 [email protected]
🎥 Sneak peek: https://t.co/Yi2i2DAFET

#BCA2025 #crystallography #structuralbiology #proteincrystallization #microseeding #phaseDiagrams

[Douglas Instruments @DougInstruments]

🎉Missed our webinar on protein crystallization & phase diagrams? We’re running it again!
📅 7th May 2025
🕚 11:00am (GMT+1)
🔬 Learn how Oryx robots optimise crystallization workflows with speed and precision.

👉 Register now: https://t.co/W7sZvQ2G2G

#StructuralBiology #ProteinCrystallization #PhaseDiagrams

[Douglas Instruments @DougInstruments]

Microseeding: Take Control of Crystal Growth

Too many crystals? Not enough?
Get control with an Oryx.
Microseed dilution optimization and automatic phase diagram optimization on the Oryx platform can help you manage nucleation and growth with precision.
💎Control size and number by identifying the metastable zone and adjusting seed concentration
💎 Avoid excessive or under nucleation
💎Ideal for MicroED, XFELs, and neutron crystallographyBonus: Works seamlessly in microbatch-under-oil for quick phase diagram mapping.
🎥https://t.co/IKeCnuJb63
📨[email protected]
#MMS #DouglasInstruments #structuralbiology

[Douglas Instruments @DougInstruments]

⏳ Don't Miss Out!
Our webinar is happening on March 27th – your chance to dive into the latest in protein crystallization and phase diagram optimization!
🗓️Secure your spot now: https://t.co/tazBtd15xm

#StructuralBiology #ProteinCrystallization

[Jack Stubbs @serialstubbs]

Check out the review paper I wrote with @CourtneyLendon addressing methods of matching microcrystal preparation and sample delivery now published in @IUCrJ @SoCoBioDtp @DiamondLightSou @unisouthampton @sotonbiosci @DougInstruments https://t.co/w6oOpacad6

[Douglas Instruments @DougInstruments]

The Power of One!
One robot, one tip, endless possibilities! 🎯
🔹 Single multi-channel tip means minimal waste.
🔹 Contact dispensing ensures precise drop placement.
🔹 No consumables, just pure efficiency.
Oryx robots streamline your crystallization workflow with precision and simplicity.
💡 Want to learn more? Register for our webinar on March 27th! [https://t.co/tazBtd1DmU]
#StructuralBiology #ProteinCrystallization #PhaseDiagrams

[Douglas Instruments @DougInstruments]

Using Oil Never Felt So Good!
💡 Microbatch-under-oil crystallization with Oryx robots makes your experiments smoother than ever!
✅ Reduce evaporation for more stable conditions.
✅ Minimize sample waste while maximizing results.
✅ Automate oiling for effortless setup.
🚀 Discover the power of microbatch-under-oil: [https://t.co/aftuemtec0]
📢 Join our webinar on March 27th to explore the benefits of automation in protein crystallization! https://t.co/pbonDmo3sx

#ProteinCrystallization #StructuralBiology #PhaseDiagrams