Just trying to be a clinician in spite of horrendous IT systems. Special interests autoimmunity,hyperinflammation (HLH), MPNs plus art,Brøndby IF and chicken
@IhabFathiSulima Feel free to reach out at my hospitalmail [email protected] if you - as most - are still unfamiliar with VEXAS and hyperinflammation related to this.
@ManualOMedicine Classic IHC signature 123-4-56. A histiocytocis (acc to WHO) that's not a histiocytosis (histiopathologists). A diseases that sometimes respond to myeloid- and sometimes to lymphoma-directed tx. And oftentimes to exceedingly costly targeted tx. #BPDCN!
@AaronGoodman33 Birbeck granules - pLCH. Primary Tx- stop smoking. May well be the sole disease manifestation. But Look for systemic LCH and some patients present with solid malignancies as well. If diagnosis is uncertain consider ddPCR/cfDNA for BRAF mutation
@NicoGagelmann Difficult - can't figure this one out. Looks infectious to me but not aspergillus, mucor, pcp and probably not tb. Dont know histioplasmosis well enough? Not PAP. Not pLCH. Is it a #VEXAS pt have seen al sorts of weird scans wo infection in these patients??
@nihardesai7@BrownJHM@NicoGagelmann The most provocative diagnosis these days would be that the patient is female. Let's hope for the that person that it has CML and not Ph' ALL.
You are a young #medicine resident, again 🤣
You are called in for a consult by your OBGYN colleagues, this happens a lot🤣
THROMBOCYTOPENIA (TCP) yet again !
But now we know the basics, rule out pseudoTCP etc. So that's done!
The patient is really thrombocytopenic
What now?
@AaronGoodman33 @EricLauDO@HistiocyteSoc The HS covers both #Histiocytoses and #hlh - we are pediatricians and adult physicians as well as basic scientists. We have an online ListServ for discussing difficult cases. online seminars -EBV-induced hyperinflammation next week!! and importantly we have great fun when we meet
Not your typical Linkedin post but as many of you know I´m passionate about histiocytosis - and music.... And beginning to master one of the disciplines.
Went to see Depeche Mode yesterday - and inspiration came to me on my way home from work when I was t…https://t.co/70fM2M3jSt
@AaronGoodman33 @EricLauDO@HistiocyteSoc Go check out https://t.co/1DgDxx0Eny we are a welcoming society. Will write to the meeting organizers - a session on how to use SoMe for Meded in rare diseases could be great. #1
Hey #medicine residents !!
Time to talk about EOSINOPHILS today. Not as common a consult as thrombocytopenia and anemia but important nonetheless.
A short 🧵 to touch upon all things eosinophilia 👇🏻
#MedTwitter