Ganesh Pathare

Assistant Prof @CityUHongKong | Bone-Kidney Axis & Regeneration | FGF23-Klotho | Veterinarian-Scientist 🧬🔬 | Vet Education

[Ganesh Pathare @DrGPathare]

CKD and the aging-like phenotype may be driven by proximal rather than distal nephron Klotho dysregulation.

Invited mini-review: Klotho Revisited: Tubular Heterogeneity Reshapes Mineral Metabolism, Aging, and CKD

https://t.co/N3ZLal2wMn

[Daniel G. Fuster @Dan_Fuster]

New hope for people with kidney stones: The EMPASTONE trial launched yesterday with enrollment of the first 2 patients.
More:
https://t.co/6mYt3srivX
https://t.co/J8j0Ih6S8P

[Tesla @Tesla]

Engineering tests of the first production Cybercab have begun in Austin

[Ganesh Pathare @DrGPathare]

Thank you to @CityUHongKong for showcasing our recent research on Klotho biology. It's a pleasure to see our work reach a wider audience.

[CityU Hong Kong @CityUHongKong]

Klotho, the "longevity protein," has long been a black box — we knew kidneys produced it, but not how it worked. #CityUHK Professor Ganesh Pathare, in collaboration with Professor Johannes Loffing, from the University of Zurich, have finally mapped its precise kidney functions - cracking the code! 🔑

Two game-changing discoveries:
🌟 Distal tubule Klotho → regulates calcium & bone health
🌟 Proximal tubule Klotho → maintains phosphate & circulating sKlotho levels

Overturning long-held assumptions, this study opens new doors for treating chronic kidney disease! 🩺
🔗 Read more: https://t.co/5cq2TMAWGW

[Ganesh Pathare @DrGPathare]

Link to the paper: https://t.co/UFMIOhOLal

[Ganesh Pathare @DrGPathare]

Antiaging, Klotho, kidney or mineral metabolism interests you? 👇🧵

After 5+ years of work, we’re excited to share our research just published in Kidney Int. It dissects nephron segment-specific roles of Klotho in the kidney. @Kidney_Int @ISNkidneycare @CityUHongKong @UZH_en

[Ganesh Pathare @DrGPathare]

Limitation / open question:

How exactly proximal and distal nephron segments secrete sKlotho into blood vs urine is still unclear.
And importantly- what is urinary sKlotho actually doing? Biomarker only, or local tubular function?
Definitely an area for future work.

[Ganesh Pathare @DrGPathare]

@biopatrika

[Ganesh Pathare @DrGPathare]

Open postdoc position in our group!!

More about our research: https://t.co/xhCpURO4po. Interested candidates can contact: [email protected]. Please share with anyone who might be interested.

[Ganesh Pathare @DrGPathare]

Open PhD position in our group! Feel free to share it with someone who might be interested in..

[Ganesh Pathare @DrGPathare]

Open PhD position in our group! Feel free to share it with someone who might be interested in..

[Ganesh Pathare @DrGPathare]

High-salt diet modulates endocrine regulation between cortisol and FGF23 https://t.co/xAFRRs81Lm