“I wrote this because I can’t speak about it.
I wrote this because I want you to know that I will make sure that you live on.”
@RBLeipzig and @equipenatciv winger Yan Diomande on the life of his sister, Roxane. https://t.co/6wQmpdWTSi
it has been a few wild months in biotech recently:
1) retatrutide phase 3 went off the charts: 28.3% bodyweight lost, 65% of patients dropped below obesity BMI threshold
2) Relay Therapeutics hit 60% response rate in rare vascular anomalies: better safety and efficacy than the existing Novartis treatment
3) FDA approved Datroway for first-line triple-negative breast cancer: five month survival advantage over chemo
4) biotech NewCo model surging. small teams in-licensing clinical stage assets from China: bypassing early discovery entirely and moving straight to trials
5) Life Biosciences started the first ever human trial to reverse cellular aging.
6) baby KJ received a custom CRISPR therapy designed for his exact genome in 6 months and it worked
7) peptides went from felony to federal policy and psychedelics got a presidential executive order.
8) someone sequenced their genome on a kitchen table for $1,100, many such cases
9) Isomorphic Labs raised $2.1B on top of $600M. Demis Hassabis betting everything that AI designs drugs better than humans.
10) UCB, Lilly, BMS, Incyte all moved on AI drug development in the same window
AND, we're still very bullish on gene therapy, longevity, human data infrastructure, neurotech, peptides and protocol validation, epigenetic reprogramming, and generally non-consensus bio
the stuff that felt fringe two years ago is becoming the category
if you are building or investing in any of this, Superhuman Fund II is actively deploying. let's talk
bio/acc.
I don’t know how else BlueCo’s failure is better defined this season than Sunderland - promoted from play-offs - on course to beat us twice & get higher quality of European football.
Alonso hire cannot hide the calamity of this season.
No Chelsea player had more touches (83), won more duels (8), made more tackles (5) or made more interceptions (2) against Liverpool than Reece James.
And he did it playing multiple positions. 👏