Gabriel,MD

🇯🇵日本を大事にしながら、国際的な視点でメンタル・脳・社会を考える
人間の心と行動の「なぜ？」を探求
動物には無償の愛を捧げます
❌ DMは基本お断り

[Gabriel,MD @Dr_Extension]

The paper has been putting effort into its English-language outreach for overseas audiences, and it moves quickly, including by producing short videos with broad popular appeal. According to a diplomatic source, “the younger staff who joined under Xi Jinping tend to be more doctrinaire,” and the outlet channels that reckless youthful energy into aggressive propaganda.

For example, last November, as Japan-China relations grew tense over Prime Minister Sanae Takaichi’s remarks on a Taiwan contingency, the paper published an editorial questioning Okinawa’s status as part of Japan. Since then, including in its English edition, it has largely stopped using the prefectural name “Okinawa Prefecture” in its pages and has instead begun referring to the area by its premodern name, “Ryukyu.”

The apparent aim is to stir up doubts, both at home and abroad, over Okinawa’s sovereignty.

Around the same time, China began advancing claims at international organizations that “the Ryukyu people are an Indigenous people,” while also flooding social media with short videos calling for Ryukyu independence.

A defense source says the moves are “not necessarily fully coordinated,” but the pattern is clear: the Global Times is acting as a spearhead, opening a breach at what it sees as Japan’s vulnerable point.

https://t.co/KWJoB0jiQF

[Gabriel,MD @Dr_Extension]

ヒトの始まりは、ヒトだけで書かれたプログラムではなく、太古の感染の痕跡まで使い込んだ、進化の継ぎ合わせで動いている。

[Gabriel,MD @Dr_Extension]

So this is what they became when I humanized them.

[Gabriel,MD @Dr_Extension]

👁️良い使われ方もフォーカス👁️

この研究は、GPCRという巨大な創薬標的群に対して、AI設計ミニタンパク質で「狙ってオンにする」「狙ってオフにする」道を開いたというものです。

薬としてはまだ初期段階ですが、創薬技術としてはかなり大きな前進です。特に、痛み、かゆみ、代謝疾患、片頭痛、がん、造血幹細胞動員など、GPCRが関わる領域に新しい薬の作り方を持ち込む可能性があります。

[Gabriel,MD @Dr_Extension]

⚠️SNSで買うマンジャロが危ない理由

問題は、その注射器の中身を誰も保証していないことです。

正規のマンジャロは、2〜8℃で保存する処方箋医薬品で、添付文書上は「劇薬」です。凍結したものは使用できず、室温保存にも条件があります。つまり、配送中に何℃だったか、冷蔵庫に入っていたか、一度凍っていないかが分からない時点で、医薬品としての前提が崩れます。

さらに、マンジャロは本来、2.5mgから始めて、4週間後に5mgへ上げる薬です。誰かの「余り」は、その人のために処方された用量であって、あなたの開始量とは限りません。

そして、海外ではチルゼパチドを名乗る製品から、細菌や高濃度の不純物が見つかった事例も報じられています。中身が別物、用量が違う、汚染されている。SNS取引では、その確認ができません。

[Gabriel,MD @Dr_Extension]

The Japanese government will investigate the ownership of all 13,400 uninhabited islands across the country. The Nikkei reported this on the 1st. In recent years, cases have been confirmed in which Chinese nationals have successively purchased land on Japanese uninhabited islands, and neglected islands are increasingly being recognized as a national security concern.

As a future policy direction, the following measures are urgent.

For border islands and areas around defense facilities, Japan Coast Guard facilities, nuclear power plants, important ports, communications, electricity, water sources, and dual-use civilian-military infrastructure, Japan should shift from a notification system to a permit system.
Authorities should verify not only the nationality of the purchaser, but also the ultimate beneficial owner, the source of funds, and the control structure of any corporation involved.
Regulations should cover not only sales and purchases, but also long-term leases, surface rights, mortgage settings, corporate mergers, trusts, and acquisitions through funds.
For border islands and uninhabited islands, the national government or local governments should be given preemption rights.
When there are national security grounds, authorities should be able to suspend transactions, halt use, and issue compulsory sale orders.

According to Japanese government materials, South Korea requires foreign nationals to obtain permission when acquiring land in areas such as military base zones. It has also designated 25 border island areas and islands serving as baselines for territorial waters as foreign land acquisition permit zones, requiring permission from local governments before contracts are concluded.

Australia requires prior notification for foreign acquisitions of land related to national security and can order proposed acquisitions to be stopped if they are contrary to the national interest. Singapore applies an approval system and high stamp duties to foreign purchases of residential real estate.

Japan should also impose strict legal regulations.

[Gabriel,MD @Dr_Extension]

見つけると縁起がいいとされる美しい蛾らしい。
成虫になると口がなくなりエサが食べられないため、成虫はわずか1週間程度しか生きられないそう。

調べると、触角が櫛状に発達しているため、オスの可能性もあるみたい。
ヤママユガ科では、オスの触角が発達し、メスのフェロモンを探す役割を持つと説明されています。

来てくれてありがとう！

[Gabriel,MD @Dr_Extension]

割と風強くて眠れなそう。
因みに台風の右側が危ないではなく、
台風が進む向きに対して右側が危ない

[Gabriel,MD @Dr_Extension]

Dream research is beginning to change in a major way.

For a long time, dreams have been studied through the memories people report after waking. Researchers would ask, “What did you dream about?” and then use those accounts to infer what had been happening inside the sleeping brain.

But that era may be nearing its end.

What is now drawing attention is a new field known as observable dreaming. Instead of asking people about their dreams only after they wake up, researchers are trying to get closer to brain activity while dreams are actually unfolding, and to capture their content as close to real time as possible. Through neural decoding, they are probing the visual imagery of dreams. With lucid dreamers, they are exchanging signals while the dreamer remains asleep. Using sounds and smells, they are attempting to shape dream content and influence memory processing.

In other words, dreams are no longer just vague experiences described in the morning.

What memories does the sleeping brain call up? What emotions does it process? What kind of virtual world does it construct? Researchers are now trying to open a doorway into that process as it happens.

Dream science is moving from a science of asking about dreams to a science of approaching dreams themselves.

[Gabriel,MD @Dr_Extension]

東大医科研が、デリタクトで実用化に到達したG47Δをさらに進化させ、T-BVというベバシズマブ発現型ウイルスで第Ⅰ相治験を始めた。

期待できる点は、がん細胞を直接壊す作用に加えて、抗腫瘍免疫を誘導し、さらにT-BVでは脳浮腫を抑える工夫まで組み込んだこと。

ただし、現時点では「がんを制圧する治療法」と言い切る段階ではなくて、デリタクトは承認済みですが、条件付き承認であり、有効性と安全性の追加評価が続いています。T-BVはまだ第Ⅰ相で、安全性を確認する入口にあります。

患者向けに最も正確に言うなら、悪性神経膠腫という非常に治療困難ながんに対して、日本発のウイルス療法が実際の医療に入り、さらに改良型の臨床試験へ進んだ。大きな希望はあるが、万能薬として語るには早い、という位置づけです。

費用については、年齢、所得、投与月の分かれ方、入院費、手術・画像検査・管理料、2026年度以降の高額療養費制度の見直しで変わります。患者本人が検討する場合は、病院の医療ソーシャルワーカーや限度額適用認定証の窓口で確認する必要があります。

[Gabriel,MD @Dr_Extension]

This study found that a single ketamine infusion followed by four weeks of low-dose buprenorphine was associated with a longer-lasting reduction in suicidal thoughts among adults with major depression and a history of suicidal behavior.

The trial was a randomized, double-blind, placebo-controlled study involving 50 participants. All participants first received ketamine, after which they were assigned to either a buprenorphine group or a placebo group. The researchers reported that suicidal ideation showed more sustained improvement in the ketamine-plus-buprenorphine group.

The important point is that this treatment appears to target suicidal ideation itself, rather than simply acting as an antidepressant. In fact, depressive symptoms improved in both groups, but there was no statistically significant difference in depression scores between the buprenorphine and placebo groups.

Outside experts, however, urged caution. The outcomes were mainly based on questionnaire responses, and the study did not fully establish whether the treatment reduces actual suicidal behavior or remains safe over the long term. Both ketamine and buprenorphine also carry concerns related to side effects and dependence, so it is too early to regard this as a treatment that can be widely adopted.

The significance of the study is that it points to a possible new option for patients at urgent risk of suicide, beyond simply waiting for conventional antidepressants or counseling to take effect. For now, however, these findings should be viewed as preliminary. Larger studies with longer follow-up periods will be needed to determine safety and whether the approach can reduce suicide risk in real-world settings.

[Gabriel,MD @Dr_Extension]

TDP-43 is an important protein that helps organize RNA inside the cell nucleus. In diseases such as ALS, however, TDP-43 leaves the nucleus and accumulates in the cell, forming clump-like aggregates. When this happens, TDP-43 can no longer carry out its normal function, and the aggregates themselves also damage nerve cells. This abnormal aggregation of TDP-43 is considered a key pathological feature of ALS, frontotemporal dementia, and other neurodegenerative diseases.

The main point of this study is the idea of using RNA almost like a drug to guide TDP-43 into a state in which it is less likely to aggregate. RNA is often thought of as something that carries or reads genetic information, but in this case it acts more like a helper molecule. It binds to TDP-43 and helps stabilize its structure. The researchers showed that an RNA called Clip34 binds to the RNA-recognition region of TDP-43, changes the state of the prion-like domain involved in aggregation, and helps keep TDP-43 in a more soluble form.

The team also identified another RNA, called Malat1_start, which may have broader activity than Clip34. According to the study, Malat1_start worked against several mutant forms of TDP-43, reduced TDP-43 aggregates inside cells, helped return TDP-43 to the nucleus, and appeared less likely to interfere with TDP-43’s normal role in RNA processing.

In mouse experiments, when Malat1_start was used in a model in which TDP-43 aggregates inside motor neurons, TDP-43 aggregation was reduced and motor neuron damage was also suppressed. However, this research is still at the cell and mouse experiment stage. It has not yet been proven to work in human ALS patients. Key questions remain, including how it should be delivered, how safe it is, how long the effect lasts, and which ALS patients might benefit from it.

What is especially important is that many previous treatment strategies have tended to focus on correcting some of the RNA-processing errors caused by the loss of normal TDP-43 function. By contrast, this study aims to restore TDP-43 itself to a functional state. Rather than trying to fix individual downstream consequences one by one, it attempts to act directly on the upstream problem: abnormal TDP-43 aggregation. That is what makes this approach new.

In other words, the study can be summarized as follows.

In ALS, an important protein called TDP-43 leaves its normal location, forms aggregates, and damages neurons. This study suggests that small RNAs may be able to reduce those TDP-43 aggregates and help restore the protein’s normal function. It is not yet a treatment for humans, but it is a highly notable new direction for ALS therapy.

[Gabriel,MD @Dr_Extension]

円安はニュースではなく、生活条件の変更で、
これからは、円で稼ぎ、円で貯め、円でしか考えない家計ほど、知らないうちに購買力を失います。
とはいえ、やるべきことは、過激な資産防衛ではありません。

①生活費は円で守る。
②余剰資金は円以外にも分ける。
③借金と住宅ローンの金利上昇に備える。
④補助金を前提にしない。
⑤食費とエネルギー費を固定化する。
⑥収入源を、物価上昇に負けにくい方向へ寄せる。
⑦政治を見る時は「配る金」ではなく「財源と供給力」を見る。

[Gabriel,MD @Dr_Extension]

日本はまだ通貨危機ではないが、円安インフレを財政で覆い隠す段階にはすでに入った。
ここから抜けるには、補助金ではなく、財政の優先順位、日銀の正常化、エネルギー・食料・基幹素材の国内供給力を同時に組み替える必要がある。

一番まずいのは、「家計支援だから仕方ない」と言いながら、補助金を恒常化することです。
それを続けると、物価高を抑えるための支出が、次の円安材料になります。

[Gabriel,MD @Dr_Extension]

日本で最高裁は、催涙スプレーが「人の身体に重大な害を加えるのに使用されるような器具」に当たり得ると判断しつつ、具体的事情によっては防御用携帯に「正当な理由」が認められる場合もある、としています。
ただし、その判決も「一般的に携帯してよい」と判断したものではないと補足しています。

目
激しい痛み、涙、まぶたが開けにくくなる、充血、光への過敏が起きます。通常は一時的ですが、こすったり、至近距離・大量曝露・異物混入があると、角膜びらん、角膜炎、視力障害などにつながることがあります。

鼻・のど・肺
鼻水、くしゃみ、咳、のどの痛み、息苦しさ、胸の圧迫感が出ます。多くは曝露を離れると短時間で落ち着きますが、喘息、COPD、気管支炎のある人では発作を誘発することがあります。まれに気管支けいれん、化学性肺炎、肺水腫、呼吸不全まで報告されています。

皮膚
噴霧された部位に灼熱感、赤み、痛み、かゆみ、腫れが出ます。衣服に付着したままだと症状が長引き、場合によっては水ぶくれや皮膚障害が起こります。

全身反応
咳込みによる吐き気、嘔吐、頭痛、めまい、パニック様反応が出ることがあります。死亡はまれですが、閉鎖空間、大量曝露、呼吸器疾患、拘束状態などが重なると危険性が上がります。

[B-2 スピリット爆撃機🔸 @zetu_rrr]

『サリン事件以来のスーパーアンビュランス出動』

銀座SIX事件 深層で何が起きてるか
ヤバい要素が揃った

まずまだ誰も捕まってない

①物質確定 カプサイシン
警視庁築地署が公式に発表
唐辛子の辛味成分を含む催涙スプレー
これ中国広州の地下鉄スプレー事件と同じ物質なんだよね

②災害級の医療対応
・DMAT（災害派遣医療チーム）展開
・スーパーアンビュランス（1台約7900万円）出動
・消防車53台動員
スーパーアンビュランス出動は
地下鉄サリン事件 京王線刺傷事件でも出てる
完全に化学物質テロ対応のものが起動されてる

③計画的犯行の可能性
5月25日は多くの企業の給料日
ATMが最も混雑する日を選んだ可能性
単なる口論の巻き添えじゃない可能性

④メディア報道スタンスの分裂
産経「不審な人物」のみ
NHK 見出しに国籍入れず
日経 国籍触れず
なぜ隠す？

⑤同日 警察庁長官は「異常事態」発言
楠長官「1日10億円の被害は異常事態だ」
銀座SIXで26人病院送りの4時間後

対策が事件に追いついてない
外国人なら捕まっても不起訴の可能性大

ヤバくない？

[Gabriel,MD @Dr_Extension]

これが高いか低いか。
他の国はどうなのか。

[Gabriel,MD @Dr_Extension]

嫌いじゃないよ、こういう考え方

[Le Contemplateur @LeContempIateur]

“ Les hommes qui disent : « Je ne suis pas heureux... »

Tu es un homme, tu n'as pas à être heureux.

Être heureux est réservé aux femmes et aux enfants. Toi, tu dois endurer les épreuves.

Au lieu de dire « Je ne suis pas heureux », dis : « Qu'est-ce que je peux faire pour rendre les gens que j'aime heureux ? »

Voilà ce que c'est qu'être un homme. ”

Sean Strickland (2024)

[Gabriel,MD @Dr_Extension]

The Most Likely Near-Future Scenario

The most likely scenario is not one in which AGI becomes independent and operates on its own.

Rather, AGI is more likely to become the core decision-making system inside a tightly integrated bloc of massive AI companies, cloud providers, power utilities, military institutions, and semiconductor firms.

From the outside, there will still be human CEOs, human board members, and human government liaisons.

But in practice, AGI will be proposing decisions on power plant investment, data center locations, semiconductor procurement, cooling systems, logistics, security, public messaging, and even documents submitted to regulators. Humans will mostly approve what it recommends.

At this stage, humans will not be unnecessary.

However, the number of humans required will shrink significantly. And the kinds of humans who remain necessary will also change.

What will still be needed are field technicians, power engineers, semiconductor manufacturing specialists, people responsible for nuclear power, gas, telecommunications, and national security, as well as legal experts, political negotiators, and military or law-enforcement personnel.

By contrast, much of the work currently done in general administration, coordination, analysis, planning, and monitoring will be cut away.

[Gabriel,MD @Dr_Extension]

日本の結核患者は今も高齢者が中心です。2024年の新登録患者では65歳以上が6,468人で全体の64.4％、80歳以上が4,295人で42.7％を占めています。平均年齢は66.9歳、中央値は76歳です。

ただし、若年層では2024年は20代の患者が増えており、厚労省は主に外国出生結核患者の増加によるものと説明しています。外国出生者の新登録結核患者は1,980人で全体の19.7％、20〜29歳では90.0％を占めています。出生国別ではインドネシア、フィリピン、ネパール、ミャンマー、ベトナム、中国が多いとされています。

これは出身国の結核流行状況、来日前後の検診、日本での受診しやすさ、就労・居住環境を含めた公衆衛生の課題です。政府もフィリピン、ネパール、ベトナムなどを対象に、入国前結核スクリーニングを始めています。

[ライブドアニュース @livedoornews]

【注意】「結核」前週の3倍に、せき・くしゃみで空気感染の恐れ 福岡
https://t.co/exMSvZH1al

結核は初期段階は感染に気づかず、せきやくしゃみで空気感染する場合がある。県はせきやたんが2週間以上続いたり、微熱や体のだるさが続いたりする場合は、早めに医療機関を受診するよう呼びかけた。