EndoDmOnSpot

EndoDmOnSpot is updated review of Endocrinology and Diabetes for all healthcare providers.Account is managed by Makkah chapter of Saudi Society of Endocrinology

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The progression of retinopathy seen in the subcutaneous semaglutide study is likely a consequence of rapid glycemic lowering (similar to that seen in other settings) rather than a direct effect of the drug

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Functional NETs are defined as those that produce hormones and other vasoactive substances, which can give rise to various clinical syndromes.

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Gastroenteropancreatic neuroendocrine tumors (NETs) can secrete peptides, amines, and other molecules

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Studies of the effect of subclinical hypothyroidism on mortality show conflicting results

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نصائح لمريض السكري اثناء الحج 2

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نصائح لمريض السكري في الحج

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Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease caused by functional mutations at one of three genetic loci

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For longer-term control of hypercalcemia in patients with more severe (calcium >14 mg/dL) or symptomatic hypercalcemia due to excessive bone resorption, suggest the addition of an IV bisphosphonate

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Vitamin D replacement therapy is necessary for children presenting with low concentrations of 25-hydroxyvitamin D (25OHD; ie, <20 ng/mL [50 nmol/L]) or rickets.

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Most GLP-1 receptor agonists are initiated at a low dose and then slowly advanced to avoid adverse gastrointestinal side effects, which are relatively common, usually affecting from 15 to 45 percent of patients.

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Hyperparathyroidism and humoral hypercalcemia of malignancy (due to PTHrP) may be associated with frank hypophosphatemia

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Patients with hypercalcemia of malignancy often have higher concentrations of, and more rapid increases in, serum calcium and consequently are more symptomatic

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GLP-1-based therapies are appropriate to use in combination with metformin (and/or another oral agent), particularly in patients with existing ASCVD, when weight loss or avoidance of hypoglycemia is a primary consideration, when (A1C) is well above goal (eg, >8.5 percent)

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For individuals with LDL-C above 190 mg/dL, the genetic defects that lead to familial hypercholesterolemia (FH) are the most common underlying cause

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In patients without ASCVD, prefer long- over short-acting GLP-1-based therapies due to patient convenience and greater glycemic efficacy

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Hypoparathyroidism occurs when there is destruction of the parathyroid glands (surgical, autoimmune), abnormal parathyroid gland development, altered regulation of parathyroid hormone (PTH) production, or impaired PTH action

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In patients with hypoalbuminemia due to chronic illness or malnutrition, there may be an associated reduction in the serum total calcium concentration due to proportionally reduced binding of calcium to albumin

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In patients with type 2 diabetes and heart failure and/or kidney disease, all SGLT2 inhibitors have shown salutary effects; choice of agent is primarily dictated by provider preference, insurance formulary restrictions, kidney function, and cost.