EPoCH

Exploring Prenatal influences On Childhood Health. Improving the evidence base around maternal and paternal effects. From Dr Gemma Sharp and Dr Kayleigh Easey.

[EPoCH @EPoCH_study]

See the preprint from our latest paper here. Father/Partner data collected around pregnancy in cohorts often has less depth and breath. We investigate selection bias for available data from participating father/partners https://t.co/4rycf85yyq

[Dr Kayleigh Easey @KayEasey]

Our preprint investigating selection bias in the availability of data from fathers/partners during pregnancy in three UK cohort studies is available on medRxiv here https://t.co/S4b9SjIrxD 1/..

[EPoCH @EPoCH_study]

Come and work with me on the EPoCH study! An exciting opportunity to get the results written up and out in the world!

[Dr Kayleigh Easey @KayEasey]

It’s been great to present our @EPoCH_study at #LHRS today in such a beautiful setting at @UniofOxford. Don’t forget you can sign up to have access to our web-app showing all of our multi-cohort results here https://t.co/AP5xT0XqdP

[EPoCH @EPoCH_study]

🚨New paper🚨 We reviewed the current evidence of what paternal behaviours during pregnancy (alcohol, tobacco, caffeine, physical activity) may have on offspring mental health. Read the paper here https://t.co/XX4rr30yLY and see the linked thread below for a summary

[Dr Kayleigh Easey @KayEasey]

Wondering what the current research says for the impact paternal behaviours in pregnancy of alcohol, tobacco, caffeine use & physical activity has on offspring mental health?We study that in our latest paper here: https://t.co/JZClNxmvmh 🧵1/6
@ammegandchips @EPoCH_study @mrc_ieu

[EPoCH @EPoCH_study]

EPoCH left the country and took a trip to Norway to attend @theCEFH symposium as well as to present our work so far! Read all about the trip here in our latest blog: https://t.co/p9zVpc8a4V

[EPoCH @EPoCH_study]

Great to see results from the @WRISK_project “When trust breaks down some women may be more likely to hide their behaviour” - this has important implications for reporting bias in research too

[Centre for Reproductive Research & Communication @CRRC_BPAS]

Our abstract for this presentation is now available in the @BMJ_Open 👇🏼

https://t.co/3s4CYAZsKp

[Dr Kayleigh Easey @KayEasey]

Read about how we are investigating paternal effects in multiple cohorts within the @EPoCH_study

Read all about the study here https://t.co/jeKRCSkwnC. 6/6

[EPoCH @EPoCH_study]

🎉New paper!🎉 We carried out a large study of child epigenetics in relation to paternal prenatal body mass index (BMI). The findings are published in @IJEeditorial and explained in this tweetorial below.

https://t.co/OLxcvbeIKV

[EPoCH @EPoCH_study]

Before Christmas we attended two exciting conferences (SER and SPER). Originally planned as an in-person trip in Boston, but due to Covid-19 we enjoyed this from virtually from afar.

Read all about it here:
https://t.co/L8bXLGkRcw

[EPoCH @EPoCH_study]

Still here! Still working away on EPoCH! Still harmonising data 😬#TheEndIsNigh

[EPoCH @EPoCH_study]

Sorry for the radio silence, but we’re still here (knee deep in data preparation) and presenting about EPoCH! Thanks very much to @BEMColloquium for the invitation and the great Q&A 😊

[EPoCH @EPoCH_study]

A helpful and interesting review showing, amongst other things, that “there is no convincing evidence that changes in spermatozoal DNA methylation influence pregnancy outcomes or offspring health“ in humans (yet at least). Useful guidelines for future studies also provided. 👍

[EPoCH @EPoCH_study]

Wonderful to see this report and set of recommendations for engaging fathers in birth cohort studies. We are working on a paper showing that, if fathers’ data is missing, it can bias findings and make maternal effects appear larger than they are.

[fatherhoodinst @fatherhoodinst]

Great that @ESRC launching pilot early life cohort study. Many studies miss birth fathers – who may not be full-time co-resident, but are highly involved. Find out why this matters & how to design cohorts to engage successfully, in our report with @ScotCen https://t.co/BhEPMM5pEh

[Society for Pediatric & Perinatal Epi Research @SPER_News]

@jensellekilde from @uni_copenhagen kicks off #SPER_FatherMatters by investigating the extent to which #preconception paternal exposures are associated with child health outcomes.

[Society for Pediatric & Perinatal Epi Research @SPER_News]

This webinar covered some really interesting aspects of how father's related to fertility and child health!

But father's are often not considered in reproductive and perinatal research.

Have you ever included fathers in your studies?

Click for poll

#SPER_FatherMatters

[EPoCH @EPoCH_study]

@SPER_News And paternal participation in cohort studies is associated with lots of factors, including e.g. maternal health behaviours & offspring birthweight... opens a can of colliders! But we definitely advocate for studying dads more & are trying to identify & minimise these biases

[EPoCH @EPoCH_study]

@SPER_News @DrBolaGrace Thx for the interesting seminar. I’d be interested to hear experiences of how missing paternal data contributes to selection bias & how this impacts estimates of paternal effects, especially when comparing mat and pat effects. Our analyses suggest the bias can be substantial.

[EPoCH @EPoCH_study]

Very interesting preprint using Mendelian Randomization to study DOHaD.

The results suggest that the maternal intrauterine environment (proxied by maternal SNPs associated with birthweight) is unlikely to be a major determinant of adverse cardiometabolic outcomes.

[david_mf_evans @evans1_d]

Our MR study of DOHAD in 45849 parent offspring pairs in the Norwegian HUNT Study now on medarchive:

https://t.co/kWFw8droJh

with @Momsemat @NMWarrington @DeborahLawlor2 @rmfreathy @mendel_random @cristenw

[EPoCH @EPoCH_study]

Last week we hosted our first Research Advisory Panel meeting. It was great to meet all members (virtually) and to give them an update on what we've been doing. Thanks for a great discussion. We can't wait for the next meeting!

Read about it here:
https://t.co/oqPojpVyUh