Delighted to share our new study published in @NatureGenet, led by Xu Han and @Kehan_Ren_PhD: red blood cell nurseries look fundamentally different in mice and humans. The textbook macrophage-centered island is a mouse feature — human erythroblasts self-organize on their own. https://t.co/B0i3l8BxHy Thread below 🧵👇
We published a new preprint on BioRxiv. We uncovered a pyroptosis-driven stromal-immune circuit that explains why TET2 mutations progress to myeloid disease, and how to disrupt it. This work is led by @Kehan_Ren_PhD. https://t.co/ey7DtOLBwI
Thank you @Kehan_Ren_PhD@NUFeinbergMed for being our special guest speaker at our recent @sbudeptofmed research seminar: “Stromal cell-primed and adaptive immunity-enhanced inflammation in clonal hematopoiesis”
Thank you all for attending my talk! It was an incredible session filled with groundbreaking advancements in the bone marrow microenvironment. I’m truly honored to have been part of this.
Join me on Monday, 12/9/24, for my talk in Session 506: Bone Marrow Microenvironment—The Bone Marrow Microenvironment in Disease! 🩸
Session Time: 2:45 PM - 4:15 PM
Hope to see you there!
Learn about the iPSC-derived human bone marrow organoid model developed by @LurieCancer’s @PengJi_lab, offering potential new avenues for personalized medicine and therapeutic interventions for patients with #MDS and other diseases. @Kehan_Ren_PhD
Delighted to share our newly published article on the development of iPSC-derived human bone marrow organoid for autonomous hematopoiesis and patient-derived HSPC engraftment. https://t.co/DSHJlLRV9z Congratulations to our lead author @Kehan_Ren_PhD, soon to be on the job market
Interested in the mechanisms of DDX41 in the pathogenesis of myeloid neoplasm? Read our preprint at https://t.co/p7Rwi51yfS. In this work, we revealed an essential role of DDX41 in dissolving G4 to prevent genomic instability mediated cell death.
Today at #ASH23, @Kehan_Ren_PhD will present “Rapid Degradation of mDia2 Protein during Terminal Erythropoiesis Via an In Vivo Aid System: An Alternative Approach for Loss-of-Function Studies”
Ji Lab is traveling to #ASH23 with not one, but TWO oral presentations and TWO posters! We are ready to dive into the forefront of groundbreaking research in hematology! @NU_Pathology@LurieCancer
45 mice - body weight, spleen weight. Lungs, spleen, sternum in PFA for H&E. Plasma, femur and tibia for PK & flow. The entire collection took 170 mins, averaging at 3.8 mins/subject. It couldn’t have been possible without the great teamwork @ikadribegic@ERMIN_LI_PHD, and Pan!
Excited to share our latest findings on inflammation-driven myeloid malignancies at the first Experimental Hematopathology Scientific Symposium. Grateful for the opportunity to present at @SocforHemepath. #SH23#Hematopathology
Celebrating getting a great score on my @theNCI K99 application on the first attempt! Many thanks to the tremendous support I received from @LurieCancer and @NU_Pathology, and of course my mentor @PengJi_lab. Putting a lot of hope into having my research funded!
Call for Papers!
"Clinical and Research value of Cancer Stem Cells"
Guest Editors: Ira Skvortsova & Kehan Ren
Submit till July 31, 2021 (and get a 20% APC discount)!
For more information check: https://t.co/hLxTJrzirM or contact: [email protected]