EFFECT Trial

EFFECT Trial: Efficacy of Flucytosine & Fluconazole as Early Cryptococcal Treatment. Phase 3 RCT at 13 sites in South Africa, Tanzania, Vietnam. Funded @The_MRC

[EFFECT Trial @EffectTrial]

We have moved over to BlueSky, find us here:
https://t.co/sGOJKnNTtw

[EFFECT Trial @EffectTrial]

We are thrilled to share that we are down to double digits! 99 participants left to reach out recruitment target of 600. Looking forward to contributing meaningful data to help to #EndCryptoDeaths 🦠🏥💯
@neleshg @sile47742 @JNJarvis76 @KylaMurphyZA

[EFFECT Trial @EffectTrial]

We are thrilled to share our latest EFFECT newsletter, which can be viewed here:
https://t.co/fO3RA03PfG
Take a look at what we've been up to over the past few months to #EndCryptoDeaths

[David Lawrence @drdavidlawrence]

Great week in S Africa @MSF_southafrica discussing all things cryptococcosis, histoplasmosis & advanced HIV disease. Now @WitsUniversity where I gave a lecture on interdisciplinary research within @IMPRINT_NIHRGHR & met @neleshg & our @EffectTrial social science team @NIHRglobal

[EFFECT Trial @EffectTrial]

@neleshg @KylaComins & Michelle are in Dar es Salaam with our @NIMR_Tanzania team for a routine monitoring visit this week.
At the same time, we celebrate 200 participants enrolled onto EFFECT across all sites- congratulations to the teams for the great work to #EndCryptoDeaths

[EFFECT Trial @EffectTrial]

https://t.co/b7U4jseioY

Take a look at what we've been up to, in our latest EFFECT newsletter! It's been an exciting few months, and we are looking forward to an inspired 2024, working to #EndCryptoDeaths

[David Lawrence @drdavidlawrence]

Thrilled that today @JNJarvis76 and I were able to represent the huge and wonderful @ambitioncm2020 team and receive the @EACSociety European Hector Research Award for best clinical/epidemiological paper in HIV in the last two years. Dedicated to all participants #EACS2023

[EFFECT Trial @EffectTrial]

@MarieJT13

[EFFECT Trial @EffectTrial]

A fantastic morning today, hearing from our Community Advisory Board and a study participant's perspective, reminding us of the importance of ensuring we translate our work from bench to bedside, to #endcryptodeaths

[EFFECT Trial @EffectTrial]

Our second Investigators Meeting starts in Cape Town today! Wonderful to have so many team members here in person, looking forward to a fantastic few days of reflection, collaboration and inspiration for the way forward to #endcryptodeaths

[David Lawrence @drdavidlawrence]

Is fluconazole enough for cryptococcal antigenaemia? The @EffectTrial is exploring the impact of flucytosine plus fluconazole in South Africa and Tanzania. Thrilled to be part of this wonderful team!

[School of Health & Medical Sciences @CityStG_Health]

St George’s researchers are leading an international trial which aims to improve treatment to prevent a type of meningitis that attacks the brain in people with advanced HIV, thanks to £4.5m funding from @The_MRC.

Learn more about the @EffectTrial: https://t.co/6DuMLtURil

[EFFECT Trial @EffectTrial]

We're pleased to share the 3rd edition of our EFFECT newsletter, which can be viewed here: https://t.co/MHatzjdPlL
And a massive congratulations to our sites for reaching 100 enrolled participants, a fantastic achievement towards our goal to #endcryptodeaths. Onward to 600!

[EFFECT Trial @EffectTrial]

We are excited to share our 2nd newsletter with you all!
https://t.co/ouzlAMyMAW

[David Lawrence @drdavidlawrence]

Incredible week at the #ICCC in Kampala. Glastonbury for #cryptococcus! Great to connect with amazing colleagues, make new friends and discuss future collaborations. Phenomenal organisation by the team!

[EFFECT Trial @EffectTrial]

Valuable insights from @drdavidlawrence on patient perspectives of the @ambitioncm2020 regimen.
Bottom line: staff and patients prefer a single dose of L-Amb.
"They want one yellow, not 7 yellows"💉🟡
Now to push for implementation with @SHARECM1 and @IMPRINT_NIHRGHR
🧫🦠🧠

[EFFECT Trial @EffectTrial]

@JNJarvis76 taking us through the "bench to bedside" pipeline for the @ambitioncm2020
An excellent model, and reminder that the work is far from done when the clinical trial is finished.
We need access, advocacy and engagement if we want to #endcryptodeaths by 2030🧫🦠🧠

[EFFECT Trial @EffectTrial]

Our co-CI @neleshg presenting on CrAg screening programmes, in which the EFFECT trial is embedded. Our other co-CI @Molloy_Sile presented @EffectTrial earlier this morning during the #ICCC2023 Clinical Track CrAg Screening sessions. Working our way to #endcryptodeaths by 2030💉💊

[EFFECT Trial @EffectTrial]

Many of our investigators are participating in #ICCC2023 in Kampala this week. Today, a master class in the clinical management of cryptococcal meningitis with @drdavidlawrence @KylaComins and colleagues from @SHARECM1 discussing implementation of the @ambitioncm2020 regimen 💊💉

[Bahati @BahatiHauleTz]

I am so excited for this trial taking place in Tanzania for a probable better treatment for PLHIV with Crypto….