Elisa D'Arcangelo, PhD

🇮🇹 in 🇨🇦 and 🇨🇭. Science shenanigans at @mcguiganlab - @pmcancercenter - @IHB_Research

[Elisa D'Arcangelo, PhD @ElisaDarcangelo]

Our #epigenetic perturbation in #CAFs paper is out! Using a custom #bioengineering tool we asked if CAF activation can be altered to modulate tumor invasion. A huge THANK YOU to the formidable team behind this work ✨

[mcguiganlab @mcguiganlab]

🔥NEW PAPER ALERT🔥: our study on perturbing CAF activation to modulate tumor invasion is out in @Biomaterials. If you like bioengineering, targeted screening and cell phenotype perturbations, this story is for you! 👀 (https://t.co/Jv8cXvPhXc

[Brad Wouters 🇨🇦 @bradwouters]

Time for 🇨🇦 to Lead.

[Matthias Lutolf @TheLutolfLab]

Join us @Roche's Institute of Human Biology (IHB) as a Scientific Group Leader! Lead innovative research in #HumanModelSystems such as #Organoids. We especially seek applications aligned to our commitment to diversity and inclusion.  More https://t.co/3uVStARGPR  #TeamIHB #pRED

[Ed Conway @EdConwaySky]

It's worth being specific about this.
It means not just shrinking PRIMARY energy demand (far more doable) but also FINAL energy demand.
Eg look at the @IEA's Net Zero plan and it assumes our FINAL energy demand also drops. Thanks to efficiency gains and behavioural changes

[Elisa D'Arcangelo, PhD @ElisaDarcangelo]

I’ve had such a fantastic time at the #CrickCancerConf going back to the lab with new ideas and new inspiration! 🤓✨✨

[Wendy Hasson MD @WendyHassonMD]

9/ Insurance companies are counting on it. They know that you will not have the time, knowledge, strength, or health to overcome their barriers.

[Stephen Barlow @SteB777]

Somehow there has been an Orwellian re-invention of history, and our modern leaders are trying to pretend, that this past consensus on the flaws of our modern system were never identified, and it was recognised things needed to change.
9/

[Andrew Akbashev @Andrew_Akbashev]

Not able to produce “favorable results” in the lab? You are a “loser”.

Stay in the shadows of those who can bring cool data to the Big Prof.

Sounds familiar? It's not only about this case at Stanford.

It's about academic culture in general:

- Keep pushing for metrics. Quantity over quality. Look for flashy conclusions.

- Skyrocket your profile. Build your research enterprise. Outcompete everyone in your field.

Isn’t it how academia works today? 🤨

▫️

Albert Einstein remarked: “An academic career, in which a person is forced to produce scientific writings in great amounts, creates a danger of intellectual superficiality”. 

Peter Higgs said he could NOT replicate his discovery in today’s academic climate: “Not enough peace and quiet in the present sort of climate to do what I did in 1964”.

▫️

Wonder about the results of this “culture”?

1. Thousands of FAKE research articles are published. 30% of all scientific articles may be fake products of paper mills. There is even a special lengthy page on Wiki called “Replication crisis”.

2. Life-draining tenure requirements that fuel the rat race. Why? To ensure the university ranking and recognition is going up.

3. Most PhDs don’t see themselves in science anymore. In many places, you are not required to be creative and knowledgable. Instead, you should demonstrate you can win a race.

Everyone knows it but few things change.

▫️

I am happy that Stanford showed courage and carried out investigation. It is an excellent example of HOW to react to manipulated papers and unhealthy lab dynamic.

It's just another reminder that:

We should STOP focusing on taking “professional selfies”.

We should STOP trading our passion for glory.

Focus on science instead

#AcademicChatter #AcademicTwitter #phdchat

[Elisa D'Arcangelo, PhD @ElisaDarcangelo]

Thank you for this tour de force @nila_cwu @alisonmcguigan and the beautiful @mcguiganlab 🔥🔥

[Elisa D'Arcangelo, PhD @ElisaDarcangelo]

Preprint alert ✨#Fibroblast content is an indicator of poor prognosis in #cancer. But how does CAF content increase beyond recruitment? Check out our study on the link between CAF hyper-proliferation, phenotypic state and tumor cell invasion ✨

[bioRxiv @biorxivpreprint]

EHMT2/G9a-Inhibition Reprograms Cancer-Associated Fibroblasts (CAFs) to a More Differentiated, Less Proliferative and Invasive State https://t.co/Lu7z09b5lf #bioRxiv

[Edgar McGregor @edgarrmcgregor]

🧵Since it is becoming hard to track, here is a thread of the simply astounding weather records planet Earth has started shattering in recent weeks:

1. Dramatic flood events have begun striking various countries around the world simultaneously this week.
https://t.co/BLiyOyxHHp

[John Gibbons 🇵🇸 @think_or_swim]

This is absolutely bananas.

There is NOTHING like this on the instrumental record. Its likely impact is probably immeasurable.

But is it leading our news bulletins & on newspaper front pages?

Nope.

[Nate Bear @NateB_Panic]

The push to return to a pre-pandemic mode will have been coordinated between the highest political and media offices, with business CEOs well in the mix, if not the originating node, of this push

[Institute of Human Biology @IHB_Research]

Allow us to introduce the Multi-tissue Systems Engineering team 📣

These scientists explore novel approaches to increase tissue-tissue complexity in #Organoids 🧫

Learn more about their pioneering work: https://t.co/mDCnPFTThC

#MeetTeamIHB #MultiTissueEngineering

[Mathieu Ferron @Mathieu_Ferron]

Pedro Pascal as histological stains.

A thread.

Methylene Blue

[Alejandro Montenegro @aemonten]

Pedro Pascal as CSH Protocols covers

A thread🧵

[Ami Citri @CitriAmi]

So cool!
I feel extra sorry for vegans…
https://t.co/2H43y6QuyI