Gmelisa

[Marion Holman @Marion436842126]

9/9 I think that context is essential to interpreting any biomarker.

[Mark Kaplan @markkaplan20]

Heart disease has been the number one killer for over 100 years.

Not because we lack the science. The mechanism has been published since 1999. The evidence has been accumulating for decades. The populations that never get the disease are living proof on every continent.

We lack the will to follow where the science leads. Because the science leads away from drugs. Away from the $200 billion cholesterol industry. Away from a system that profits when you stay sick and loses revenue when you get well.

Fix the food. Fix the inflammation. Fix the insulin resistance. Fix the sleep. Fix the stress. Eliminate the seed oils. Test what matters. Match your environment to the biology your genes were designed for.

That is how you break the chain. That is how you cure heart disease. Without a single drug.

The mechanism is published. The evidence is overwhelming. The populations that already did it are alive and thriving.

The only question left is whether we choose to follow the science or continue to protect the business model.

I chose the science.

That is why I built Neo | HealthTruth.

Co-founded with:

@ifixhearts (Dr. Philip Ovadia, MD, Cardiac Surgeon)
@DrAseemMalhotra (Dr. Aseem Malhotra, MD, Cardiologist)
@carbaddictiondr (Dr. Robert Cywes, MD, PhD, Metabolic Surgeon)
@ProfTimNoakes (Prof. Tim Noakes, Head of Science)

The truth heals

[Dr. Priyam Bordoloi @DocPriyamMD]

SEVERE ANEMIA in a 47-year-old male.

Eats a normal diet.
No visible bleeding.

He was told he just had LOW IRON and was given supplements. But in Internal Medicine, this is a massive red flag.
Why? Because adult men don't just run low on iron. A clinical breakdown. 👇

[Mark Kaplan @markkaplan20]

I had a heart attack at 52. I was on the standard advice. Low fat. Whole grains. Margarine instead of butter. Statins recommended seven times.

I am 58 now. No statins. No blood thinners. No pharmaceutical drugs. My metabolic age is 43. My body fat is 12%. My fasting insulin is optimal. My inflammation is low.

Same body. Same genes. Completely different inputs.

I have told you what is making us sick. Today I am going to tell you exactly what I do every day to stay well. No theory. No supplements I sell. Just what actually works.

🧵

[Karoline Leavitt @PressSec]

"The June jobs report showed that the foreign-born labor force has fallen sharply over the past year, a sign that President Donald Trump’s crackdown on illegal immigration is reshaping the composition of the U.S. labor market."

[Mark Kaplan @markkaplan20]

Here is the question that changed everything for me.

What are you doing today?

Not yesterday. Not ten years ago when the damage was forming. Today.

Because the past is the past. The calcium is the past. It is old. Stable. Done. It sits on the wall of your artery like paint on a pipe. The pipe is open. Blood flows. I know people with calcium scores of 5,000. Perfectly healthy. Open arteries. Living their lives.

I am six years into this journey. And I do not think about having a heart attack. Not anymore.

I think about what I am building. I am creating a strong body. I am creating collaterals. New pathways. My arteries are strong. My body is stronger today than the one that broke at 52.

That is the shift nobody talks about. You stop playing defense. You stop living in fear of dying. And you start playing offense. Building. Growing. Getting stronger.

The biggest lie about heart disease is that you cannot do anything about it. That it is genetic. That the calcium is going to grow and you are just waiting to die.

That was never true.

You have a plan. What you eat today. How you sleep tonight. The walk you take tomorrow. The stress you manage. The inflammation you stop feeding.

That is not a burden. That is freedom. That is the moment you stop being a patient and start being the one in charge.

Stop worrying. Start building. Focus on the things you can control. That is all any of us can do every day.

And it is more than enough.

The lies end here.

The truth heals

Co-founders:
Dr. Philip Ovadia, MD @ifixhearts
Dr. Aseem Malhotra, MD @DrAseemMalhotra
Dr. Robert Cywes, MD, PhD @carbaddictiondr
Prof. Tim Noakes @ProfTimNoakes

[Gmelisa @ElisaJ70]

@TheJusticeDept Please go after surrogacy clinics that primarily use American women to have Chinese babies. The alleged biological parents don’t even come get their babies, they get taken back to china by others. Total scam.

[U.S. Department of Justice @TheJusticeDept]

Birth tourism schemes exploit our immigration laws and often violate our criminal laws. The Department of Justice will prioritize the prosecutions of birth tourism schemes across the country. Actors seeking to exploit loopholes to obtain automatic citizenship for their children pose a national security threat and will be brought to justice.

[Nick Sortor @nicksortor]

🚨 WOW! Justice Alito is absolutely FUMING over SCOTUS giving the green light to birthright citizenship

"In my judgment, the court has made a mistake that will seriously affect the country's future."

"Suppose that a person's only connection to this country is that he was born here to a mother who was present just long enough to give birth and then quickly return to her native country.

Suppose that country is a strategic adversary or enemy of the United States. Suppose the child NEVER visited the United States while grow and was inculcated with hatred of this country.

According to this court, now, that person is a citizen of the United States. He can enter and leave the country as he pleases. He can travel the world on a United States passport.

Even if he plots to harm this country, he cannot be deprived of his status as a citizen, at least under current precedent." — Justice Samuel Alito in his dissent

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. I've spent twenty years as the person patients trust to interpret their bodies. And I need to tell you something that most physicians won't say out loud:

AI is about to change the power dynamic between you and your doctor. Forever.

Four days ago, OpenAI's o3 model diagnosed 18 children with rare diseases that the best human specialists at Boston Children's Hospital couldn't solve — some after nearly twenty years of searching. Published in the New England Journal of Medicine.

Two weeks ago, WashU researchers proved that nine routine blood markers can calculate your biological age — and predict cancer risk years before any tumor forms. A free calculator. Available to anyone.

Last month, AI-enhanced coronary CT angiography detected inflamed arteries in patients whose standard stress tests said "normal." Patients who would have gone home reassured and wrong.
The pattern is unmistakable. The tools that used to require a specialist, a referral, a three-month wait, and a $400 copay are migrating into your phone, your bloodwork portal, and your own hands.

And I'm watching something in my practice I never expected.
Patients are walking in more informed than some of the residents I trained. They've run their PhenoAge score. They know their ApoB. They've read the study about Lp(a) before I've had time to bring it up. They come with questions so specific that the conversation starts at a level it took me years of training to reach.
This used to threaten physicians. It shouldn't. It should liberate us.
Because here's the truth about the old model: a 15-minute appointment where your doctor runs a basic metabolic panel, glances at the numbers, says "looks fine," and sends you home — that model was never good enough. It was just all we had. It missed 75% of future heart attacks. It caught cancer late. It told women with microvascular disease they had anxiety. It filed children with rare diseases as "unsolvable."

AI doesn't replace the physician. I've said this before and I mean it — the human moment, the clinical judgment, the hand on the shoulder when the diagnosis lands — that's irreplaceable.

But AI does something the old model never could: it gives you the ability to see inside your own biology with a depth and speed that was impossible a decade ago. To track your own numbers. To calculate your own biological age. To bring data to your doctor that elevates the conversation from "am I sick?" to "where exactly am I heading, and what do we do about it?"

The patient who walks in with their ApoB, their Lp(a), their hsCRP, their PhenoAge calculation, and a list of questions from the latest research — that patient doesn't threaten me.

That patient is the easiest person in my practice to keep alive.
Because they've already done the one thing most patients never do: they stopped waiting for permission to understand their own body.

I went into medicine because I wanted to help people live longer. What I've learned is that the patients who live longest are the ones who took ownership — not of my job, but of their own data, their own questions, and their own decisions.

The tools are here. The research is published. The calculators are free. The blood tests cost less than a dinner out.

You don't need to wait for your annual physical to find out what's happening inside you. You don't need permission to understand your own biology. And you don't need to accept "looks fine" from anyone — including me — when the science offers a deeper answer.

The revolution isn't coming. It's in your pocket. In your patient portal. In the published studies you can read yourself.

The only question left is whether you'll use it — or keep waiting for someone to tell you it's time.
Your body. Your data. Your life.

Take ownership. Your future self is counting on it.

[Gmelisa @ElisaJ70]

@Marion436842126 @GTnate56 Thank you. Curious if there is a calculation you used to note my insulin resistance od 2.0-3.0 and what that is? Also does apoB of 89 with high particles worsen my outlook?

[Steve Hilton @SteveHiltonx]

We are in Texas. Just filled up for $3.59. In L.A. on Monday it was $8.59.

Californians: It's not the Iran war. It's not "Trump." It's Democrat policies that have given us the highest gas prices in America.

You can have $3.00 gas but you have to VOTE for it in November.

[Gmelisa @ElisaJ70]

@Marion436842126 @GTnate56 I have pattern A, lp(a) 18. All looks good except apoB came back high as did small and medium particles. LDL 115, HDL 68, trig 61. Glucose 91. A1c 5.3. Cardiologist already saying my results warrant statin. All of this testing started because of CAC 57??? I dont want statin

[Gmelisa @ElisaJ70]

@femalelongevity So just got advanced lipid panel. ApoB is 89 under the lab threshold of 90. LP(a) 18. But what does high LDL particles mean, high small and medium LDL. Everything is goo. Triglycerides 61, hdl 68, glucose 91 good a1c?

[Gmelisa @ElisaJ70]

@Marion436842126 i have excellent lipid panel and ratios. Lp(a) and ApoB within range but then LDL-P came back high along with LDL small and medium size, pattern A. Just curious if this particle size with mild CAC score is enough risk to warrant statin. Its all so confusing.

[Gmelisa @ElisaJ70]

@llosauro @hyderabaddoctor 57 in LAD here !

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. I prescribe cholesterol-lowering drugs every single day. They save lives. That science is settled and I will never tell you otherwise.
But I'm going to say something that will make a lot of my colleagues uncomfortable — because someone needs to say it, and your doctor probably won't.
Too many physicians make you feel crazy when you bring up statin side effects.
You walk into your appointment and say "my muscles ache constantly" — and you're told it's in your head. You say "I'm exhausted all the time" — and you're told it's your age. You say "my sex drive disappeared" — and you get an awkward silence followed by a subject change. You say "I don't feel like myself anymore" — and you're told the benefits outweigh the risks, take the pill, stop reading the internet.
I've watched it happen in my own field for twenty years. The conversation gets shut down. The patient gets dismissed. And then they do the one thing we should be most afraid of — they stop the medication entirely, without telling us, and lose the cardiovascular protection that's keeping them alive.
That is the real cost of not being honest. Not the side effects themselves — the silence that drives patients away from treatment.
In my practice, I see statin-related complications in at least 25% of my patients. Muscle pain. Fatigue that doesn't resolve with sleep. Reduced sexual drive. Brain fog. Cramping. Joint stiffness. Weakness that makes exercise — the very thing we tell them to do — feel impossible.
Some of these improve with CoQ10 supplementation and optimizing vitamin D. Many do not.
I wrote about the diabetes risk of statins in a New York Times op-ed in 2012. The backlash from the cardiology establishment was immediate. I was told I was undermining trust in a life-saving drug class. Fourteen years later, every major guideline acknowledges the risk I warned about. It's in the prescribing information. The physicians who attacked me for saying it now teach it to their residents.
The truth doesn't care about professional comfort. It never has.
Now a paper published this week in Science Advances has finally explained the mechanism behind statin myopathy — and the finding validates what millions of patients have been telling their doctors for years.
Researchers discovered that statins activate the NLRP3 inflammasome in muscle cells — triggering an inflammatory cascade that causes muscle cell death, activates atrophy pathways, and disrupts muscle metabolism. This is entirely independent of the drug's cholesterol-lowering effect.
The muscle damage isn't caused by lowering cholesterol. It's caused by a completely separate pharmacological action through a different pathway.
The critical implication: the side effect can potentially be separated from the benefit.
Blocking NLRP3 or restoring isoprenoids prevented muscle cell death without interfering with cholesterol reduction. Future therapies could preserve the cardiovascular protection while eliminating the muscle toxicity.
Even more striking — the researchers found that background systemic inflammation significantly lowered the statin dose needed to trigger muscle damage. Patients with chronic inflammation, gut dysbiosis, or metabolic syndrome may be experiencing myopathy at doses their doctors consider "too low to cause problems." They're not imagining it. Their inflammatory state is priming the pathway.
The muscle pain was never in their heads. It was in their NLRP3 inflammasome. And we finally have the molecular proof.
Here's what I actually do in my practice — because I refuse to choose between protecting the heart and respecting the patient.
Whenever possible, I avoid statins as my first-line approach for eligible patients by using alternatives that lower LDL through entirely different mechanisms with no muscle toxicity:
PCSK9 inhibitors — Repatha and Praluent. Injections every 2-4 weeks that dramatically lower LDL without touching muscle tissue. No myopathy. No fatigue. No brain fog. For patients who can access them, these are transformative.
Inclisiran — Leqvio. An siRNA injection I administer twice a year in my office. It silences the PCSK9 gene in the liver. Two shots a year. LDL drops roughly 50%. No muscle side effects. No daily pills. Now approved as first-line monotherapy. This is the future of lipid management and I use it aggressively.
When statins ARE clinically necessary — and sometimes they are, especially post-heart attack or in combination therapy — I choose hydrophilic statins like rosuvastatin or pravastatin. These do not easily cross the blood-brain barrier. The cognitive complaints — the fog, the memory issues, the feeling of "not being yourself" — are substantially less common with these formulations because the drug stays out of the central nervous system.
I never prescribe a statin without CoQ10. 100-300mg daily. Statins deplete the cellular energy molecule your muscles and heart depend on. Replenishing it reduces muscle symptoms in many patients. It should be standard practice. The fact that it isn't is a failure of our field.
I check vitamin D and optimize it aggressively. Low vitamin D — which is epidemic — worsens muscle symptoms independently and compounds whatever the statin is doing. Target 50-80 ng/mL, not the bare minimum of 30.
Bempedoic acid — Nexletol — for patients who can't tolerate any statin. Works upstream in the cholesterol pathway and is not active in muscle tissue. Specifically designed to avoid myopathy.
Ezetimibe added to a lower statin dose. Cut the statin intensity, add ezetimibe to maintain the LDL reduction, and halve the muscle exposure.
There is no excuse in 2026 for telling a patient "just deal with the muscle pain." The toolbox is deep. The alternatives exist. The only barrier is a physician's willingness to listen and adapt.
I want to speak directly to every patient who has been dismissed.
Your muscle pain is real. Your fatigue is real. Your cognitive changes are real. Your loss of drive — in every sense of the word — is real. A paper in Science Advances just proved the mechanism. You were never crazy. You were experiencing a documented inflammatory response in your muscle tissue that your doctor didn't have the science to explain — until this week.
And I want to speak directly to my colleagues.
We have to be honest. Not just about the benefits — which are enormous and undeniable — but about the side effects, the mechanism, and the alternatives. Patients who feel heard stay on treatment. Patients who feel dismissed stop their medications in silence — and die from the heart attacks we could have prevented if we'd simply been willing to have an honest conversation and switch the approach.
The cardiologist who tells you statins are flawless is not protecting you. The wellness influencer who tells you statins are poison is not protecting you either. The truth lives in the middle — where it always has.
Statins save lives. The side effects are real. The mechanism is now proven. The alternatives exist. And you deserve a doctor who holds all four of those truths at the same time.
Both things can be true. They always could.
Now we have the science to prove it.

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. Let me tell you what we now know — on the record, documented, and undeniable — about Anthony Fauci and the pandemic. And then tell me this man deserved a pardon instead of a prosecution.
Fauci's NIAID funneled taxpayer dollars through EcoHealth Alliance to the Wuhan Institute of Virology to fund gain-of-function research on bat coronaviruses — engineering them to be more transmissible and more dangerous in human cells.
He then sat in front of Congress, looked Senator Rand Paul in the eye, and said: "The NIH has not ever and does not now fund gain-of-function research in the Wuhan Institute of Virology."
DNI @TulsiGabbard office has now confirmed that was false. The intelligence community's own assessment supports it. The money trail is documented.
In January and February 2020, Fauci's own handpicked advisors privately told him the virus looked engineered. Virologist Kristian Andersen emailed Fauci directly: the genome was "inconsistent with expectations from evolutionary theory" and some features "(potentially) look engineered."
Days later, Fauci organized a private teleconference. Within weeks, those same scientists published the "Proximal Origin" paper in Nature Medicine — declaring the lab leak hypothesis essentially debunked. The paper that shaped global scientific consensus and shut down investigation for over a year.
Private concern became public dismissal. Overnight. After a call with Fauci.
The Lancet then published a letter — organized with connections to EcoHealth Alliance, the same group receiving the funding — signed by 27 scientists declaring the lab leak a "conspiracy theory." Several signatories had undisclosed conflicts of interest directly tied to the Wuhan research.
That letter didn't just shape opinion. It was used by social media platforms to justify censoring physicians, journalists, and scientists who asked legitimate questions. Careers were destroyed. Medical licenses were threatened. The scientific debate that should have happened in February 2020 was suppressed for three years.
Fauci was the highest-paid employee in the entire federal government. Over $480,000 per year. His household net worth reportedly grew substantially during the pandemic. He received a Presidential Medal of Freedom.
And when the investigations finally closed in — when the congressional hearings revealed the emails, the funding trail, the private-to-public reversals — he received a preemptive presidential pardon.
Not exoneration through investigation. A pardon. The kind of legal protection you seek when you know what the investigation would find.
Innocent people don't need pardons. They need trials.
Now let me speak as a cardiologist — because this part is personal to me.
Myocarditis following mRNA vaccination is real. I've seen it in my practice. It occurs most frequently in young males after the second dose. The data is documented and published. Yet for months, physicians who raised concerns about this risk were accused of spreading misinformation — by the very public health establishment Fauci led.
The question was never whether vaccines helped some populations. For high-risk elderly and immunocompromised patients, the risk-benefit calculation was clear. The question was whether a universal mandate — including for young, healthy males with the lowest COVID risk and the highest myocarditis risk — was honest medicine or institutional overreach.
Physicians who asked that question publicly were investigated by medical boards. Silenced on social media. Called "anti-science" by the man whose own emails showed he was suppressing the science privately.
The pharmaceutical industry made approximately $90 billion from these vaccines. Pfizer and Moderna received liability immunity. The regulatory agencies that approved and mandated the products were funded in part by fees from the companies they regulated. And the man who orchestrated the public messaging received a pardon on his way out the door.
I grew up in Iran. I watched a government control medical information for political purposes. I watched physicians become instruments of the state rather than advocates for their patients. I watched institutional authority replace scientific inquiry — and I watched a nation suffer the consequences for decades.
I came to America because this country was supposed to be different.
When a public health official funds dangerous research, denies it under oath, suppresses scientific dissent, silences physicians who ask legitimate questions, and then receives a pardon instead of facing accountability — that is not public health.
That is institutional capture. And I've seen it before.
Fauci's legacy is not the millions of lives he claims to have saved. It's the millions of people who will never trust public health again — because they watched a system prioritize institutional protection over scientific honesty.
And that loss of trust will cost more lives than any single virus.
The truth is not a partisan position. Accountability is not political theater. And a pardon is not exoneration.
It's an admission.

[Gmelisa @ElisaJ70]

@markkaplan20 What was your CAC score at the time of your heart attack at age 52 and what is it now?

[Gmelisa @ElisaJ70]

@markkaplan20 Are the carbs listed in your pyramid net or consumed carbs?