Eray Enustun, Ph.D.

PhD from @ucsdbiosciences ‘23 - B.S. in ChemEng and B.S. in Mol Biology&Genetics @kocuniversity ‘16, MSc. @kocuniversity ‘18

[Eray Enustun, Ph.D. @EnustunEray]

My second “first author” paper is published by Nucleic Acids Research! We show how one of the proteins I found from the proteomics screen (Enustun et al., Nat Struct Mol Biol, 2023) is important for mRNA transfer from the phage nucleus and for their translation.

[Eray Enustun, Ph.D. @EnustunEray]

One of the best works I contributed led by one of the best scientists I know @iamamardeeep & @_KevinCorbett lab. Check out the amazing paper that explores molecular mechanism of PARIS immune system!

[Amar Deep @iamamardeeep]

Out today in @Nature!
I am thrilled to share our work on the PARIS immune system in its final published form. Huge thanks to my mentor, Kevin Corbett @_KevinCorbett, and my teammates.
See the thread below in comment section for a quick summary!
https://t.co/eDJWQUq5z4

[Eray Enustun, Ph.D. @EnustunEray]

Another great paper from our team (led by Chase), which I’m the second author of, is now published by PNAS! We investigated the selective protein import mechanism to the phage nucleus and our findings provide a mechanistic model to the system!

[Eray Enustun, Ph.D. @EnustunEray]

@Emy_nim @jina_leemon @ben_a_adler @bradyfcress Finally, I would like to thank my PIs @_KevinCorbett & Dr. Joe Pogliano for the guidance and their supports. I would like to acknowledge NIH & HHMI for their funding. I couldn't do this work without my labmates and collaborators mentioned above (+ @iamamardeeep & Yajie Gu). n/n

[Eray Enustun, Ph.D. @EnustunEray]

My second “first author” paper is published by Nucleic Acids Research! We show how one of the proteins I found from the proteomics screen (Enustun et al., Nat Struct Mol Biol, 2023) is important for mRNA transfer from the phage nucleus and for their translation.

[Eray Enustun, Ph.D. @EnustunEray]

@Emy_nim @jina_leemon @ben_a_adler @bradyfcress Relatedly, LC-MS/MS showed ChmC knockdown causes a global reduction in phage protein and effects more present for the putative virion structural proteins. We believe this is due to ChmC's role in the stages of infection where transcription occurs in the phage nucleus. 8/n

[Eray Enustun, Ph.D. @EnustunEray]

I’m not saying this because I am a part of this work, but this is an amazing work!

Led by amazingly smart & talented @iamamardeeep

[Amar Deep @iamamardeeep]

In this bioRxiv preprint, we (@_KevinCorbett ) present the architecture and activation mechanism of the PARIS antiviral defense system. Thanks to our co-authors, @Lisa_Liang13, @EnustunEray, and @PoglianoJoe, for their support in shedding light on this Anti-anti-defense system.🧵

[Eray Enustun, Ph.D. @EnustunEray]

@rachel_kandel This year I read @nathanvardi ‘s “For Blood and Money”, and I would definitely recommend it!

[Justin Meyer @justinrmeyer]

Our newest paper was published today, a capstone to our work on gain-of-function evolution, phage-bacterial interaction network formation, and microbial diversification.

[Eray Enustun, Ph.D. @EnustunEray]

Today marks the 100th founding year anniversary of the Turkish Republic 🇹🇷. Ataturk, the visionary founder, said: "Science is the true mentor" for a better world. He advocated for "world peace" by listening each other & cooperation. Today, these visions are still much needed.

[Eray Enustun, Ph.D. @EnustunEray]

@bradyfcress @_KevinCorbett @ucsdbiosciences @ben_a_adler Thanks Brady, we wouldn't be able to have this work without your collaboration and your new amazing tool (CRISPRi-ART)!

[Eray Enustun, Ph.D. @EnustunEray]

My second "first-author" manuscript from Ph.D. is now online! Thanks to my mentors (@_KevinCorbett & Joe Pogliano), @ucsdbiosciences & all collaborators including Doudna lab (@ben_a_adler & @bradyfcress) where we use their new CRISPR tool (CRISPRi-ART)!
https://t.co/42sbw6CFp0

[Kevin Corbett @_KevinCorbett]

I'm thrilled to share the latest work from my lab, showing that a bacterial anti-phage immune system encodes a ubiquitination pathway strikingly similar to our own! https://t.co/Eo2ipcmIop (1/12)

[Eray Enustun, Ph.D. @EnustunEray]

@chem_christian @_KevinCorbett @ucsdbiosciences @ben_a_adler @bradyfcress Thanks Christian! Our previous work together and the discussion during that helped a lot!

I feel like things are coming together & making more sense. Happy to discuss in private sometime for other findings that might be future publications 👀

[Ben Adler @ben_a_adler]

Fascinating biology on how the phage nucleus translocates its RNA!

For a deep dive, check out @EnustunEray 's thread 👇

[Eray Enustun, Ph.D. @EnustunEray]

Finally, special shoutouts to my amazing collaborators: @Emy_nim , @jina_leemon , @iamamardeeep , @thevillalab, @doudna_lab , @yeo_lab
Sitao Zhang (Cleveland lab) & all of my past and current labmates from Pogliano lab and Corbett lab! Thank you all!!

[Eray Enustun, Ph.D. @EnustunEray]

We believe this work shows the first jumbo phages' protein plays a role in mRNA export from the phage nucleus and translation. It is very exciting as this replication system is sensitive to RNA-targeting defense systems & future works can allow to engineer better phage therapies!