Yeah it’s the same as any medication really mate, works for some but others aren’t so lucky.
I’ve used CBD myself in the past and it helped me, it wasn’t a cure or a fix but it made me feel a little calmer.
I’m now a medical cannabis patient with Curaleaf, that does the trick for me, it’s the only thing other than lorazepam and mirtazapine that’s helped me.
@JazzaDickens10 I’m at work mate, still got time to call out your ignorance, lack of intelligence and misinformation though.
Stick to punching people in the face instead of giving medical advice, you’ve clearly found your level already.
@JazzaDickens10 Well you had time to post this medical misinformation but you don’t have time to learn the science behind your baseless claims…
That seems to be the issue really, doesn’t it?
Can I ask what experiences you’ve had with cbd/thc/medical cannabis that led you to this conclusion?
1. Endocannabinoid System (Indirect Modulation):
CBD weakly interacts with CB1 and CB2 receptors (it’s not a strong direct agonist like THC).
Instead, it inhibits the enzyme FAAH (fatty acid amide hydrolase), which breaks down the natural endocannabinoid anandamide (“the bliss molecule”).
Higher anandamide levels can promote calm and reduce anxiety-related signaling.
It may also act as a negative allosteric modulator of CB1, potentially countering anxiety-provoking effects of other cannabinoids.
2. Serotonin System (5-HT1A Receptor Agonism):
This is one of the most cited pathways. CBD acts as an agonist at 5-HT1A serotonin receptors, which are heavily involved in anxiety, mood, and fear responses (similar to how some anti-anxiety meds work).
Activation helps modulate serotonergic transmission, reducing fear and promoting relaxation.
Studies show this mediates anti-anxiety effects in animal models and human trials (e.g., simulated public speaking).
3. Other Targets:
• GABA enhancement: CBD can positively modulate GABA_A receptors (the brain’s main inhibitory system), amplifying calming signals at certain concentrations.
• TRPV1 receptors: Agonism here may influence pain, stress, and desensitization pathways linked to anxiety.
• Broader effects on brain regions like the amygdala and prefrontal cortex, reducing hyperactivity in fear circuits (seen in imaging studies).
Tbf I didn’t make my point in the way I should have and I apologise for my abrasiveness.
CBD helps millions of people with anxiety, I just don’t agree with people trying to belittle people for taking something that helps them, I do believe you have good intentions, just a little misguided.