QUESTION:
If there was no NATO and there was a world alliance instead, would the current war had been avoided? Any country that supports (or are neutral) an invading country will be removed from the alliance and thus be vulnerable to attacks.
Jimmy Carr nailed something a lot of us feel but can’t explain.
We’re living better than 99.9% of humans who ever walked the earth, hot showers, modern medicine, endless entertainment, kids that actually survive infancy, yet so many of us feel miserable.
He calls it “life dysmorphia.” We get used to how good we have it (the hedonic treadmill), then compare ourselves to everyone else and tank our own happiness.
As he puts it: happiness = quality of life minus envy.
Marcus Aurelius put it perfectly: “Very little is needed to make a happy life; it is all within yourself in your way of thinking.”
When was the last time you caught yourself feeling unhappy despite objectively having it pretty damn good?
Ray Kurzweil predicts AI will change humanity completely by 2030.
- We only have 6 years left of aging!
- By 2032, we'll be able to go through all the different possibilities. So, you get back at least a year. As you go past 2032, you'll actually get back more than a year. But you won't die of aging at that point.
- He gives an example: he has a pancreas that is actually external and generates insulin, and then he measures glucose.
- He has always said that if you take care of yourself to get to this point, there will be tools and technology to keep you alive for a very, very long time and healthy.
The future is very good for our health!
picture this
8 of the world's biggest problems getting solved in the next 12-18 months
1. obesity: retatrutide phase 3 confirmed 30% bodyweight lost. 65% of patients no longer clinically obese. FDA submission late 2026
2. testosterone decline: FDA is expanding testosterone therapy. peptide and endocrine protocols going mainstream. the 1970 baseline is coming back.
3. birth rate crisis: embryo optimization commercially available today. scientists just rejuvenated aging human eggs in the lab. fertility is soon no longer a countdown
4. aging: Life Biosciences just injected the first reverse-aging drug into a human. Sinclair's oral reprogramming pill entering XPRIZE trials.
5. Alzheimer's: Retro Biosciences dosed the first humans with a pill that reactivates the brain's cellular cleanup machinery. Phase 1 results Q3 2026.
6. cancer: daraxonrasib nearly doubled survival in pancreatic cancer. RAS has been undruggable for 40 years. they drugged it.
7. mental health: psychedelics got a presidential executive order. Compass weeks from the first FDA approval of psilocybin.
8. heart disease: inflammation replacing cholesterol as the primary target. the root cause is finally being treated not the symptom.
every single one of these has a clinical trial or an FDA action behind it right now
humanity is slowly healing
bio/acc
Elon Musk: There are no lords and peasants at Tesla. Everyone eats at the same table.
“I actually know the people on the line, because I worked on the line, I walked the line, I slept in the factory, and I worked beside them. So, I'm no stranger to them.
There are many people at Tesla who have gone from working on the line to being in senior management. There are no lords and peasants. Everyone eats at the same table. Everyone parks in the same parking lot.
At GM, there's a special elevator only for senior executives. We have no such thing at Tesla.
We give everyone stock options. Many people who are just working the line, who didn't even know what stocks were, we've made them millionaires.
And I just want to say that I'm incredibly appreciative of those who build the cars, and they know it.”
New York Times DealBook Summit, 2023
BIG anti aging news
China just launched its first large scale stem cell anti aging trial, enrolling 2,000 adults aged 50+ to test whether stem cells can help preserve strength, physical function, resilience, and healthier aging.
The therapy uses umbilical cord derived mesenchymal stem cells, which may help regulate inflammation, support tissue repair, and improve age related decline.
This is a large, multicenter randomized controlled trial, exactly the kind of serious human evidence longevity medicine needs.
That's a pretty big deal.
anti aging progress is accelerating enormously in the last few weeks.
LEV is near
ELON MUSK:
“We’re going to have universal high income.
We’ll basically just issue money to people."
"AI and robots are going to make so much stuff and provide so many services that they’ll run out of things to do for humans."
"Money will stop being relevant at some point in the future."
"AI won’t use human currency. It will care about power and mass: wattage and tonnage.”
ME:
“So just as you’re becoming a multi-trillionaire, money starts to have less value?”
ELON:
“Yeah, pretty much.”
Clubbing is dead and has been replaced by fitness & wellness.
Ppl used to party to socialize and date but now they do things like HYROX, bathhouses, and running raves.
The death of clubbing is something to be studied:
— US has lost 12% of its nightclubs in the last 24 months
— 25% of US adults didn’t drink at all last year
— Gen Z drinks 30% less than Millennials did at the same age
On the flip side:
— According to Strava, the number of running clubs recorded on the platform increased 3.5x in 2025
— 72% of Gen Z go to run clubs to meet new people
— Sauna and spa market: $11.8B → $22.4B by 2034
The post-alcohol economy is gonna be a massive category.
Building AI that Builds AI: Introducing the Sakana AI RSI Lab 🚀
https://t.co/AskX3J5oEJ
Today, we are announcing the Sakana AI Recursive Self-Improvement (RSI) Lab: a dedicated research group in Tokyo tasked with redesigning the AI development process itself using AI.
While the industry increasingly speculates about the theoretical potential of self-improving AI, we’ve spent the last two years actively laying the foundations to make it a reality:
▪ LLM²: AI models automating research to invent better preference optimization algorithms.
▪ Darwin Gödel Machine: Agents autonomously rewriting their own codebase to double software-engineering performance.
▪ ShinkaEvolve: Hyper-sample-efficient program evolution that builds novel loss functions for MoE models.
▪ ALE-Agent: Reinforcement agents outperforming hundreds of human experts via self-learning.
▪ Digital Red Queen: Open-ended adversarial coevolution laying the groundwork for RSI in cybersecurity.
▪ The AI Scientist: Towards end-to-end automation of AI research, recently published in Nature.
Now, we are unifying these breakthroughs. The Sakana AI RSI Lab is officially tasked with building open-ended, adaptive architectures that collectively self-improve.
Human intelligence did not emerge from limitless resources; it was forged through the open-ended, compounding process of evolution operating under strict constraints. We are applying this exact principle to AI.
We believe recursive self-improvement is achievable on modest, sample-efficient compute. It shouldn’t be a winner-take-all asset locked inside hyperscale clusters, but a democratized public good.
We’re scaling our team to execute this mission. We are looking for frontier scientists and engineers who are entirely unsatisfied with the brute-force status quo. If you are ready to break away from standard benchmarking and build the self-improving future in Japan, come build with us.
just look at the timeline chad
- demis hassabis, deepmind → isomorphic labs, $2.7B
- brian, coinbase → newlimit, $3.1B
- sama, openai → retro biosciences, $1.2B
- jeff the chad from amazon → altos labs, $3B
- larry, oracle → $430M into aging research
- jensen from nvidia → backing programmable biology
- dario, anthropic → acquired coefficient bio, $400M
the most successful builders of the digital age are all being pulled toward the next biggest frontier, biology
aging is basically an engineering challenge
bio/acc.
if you're under 50, cellular reprogramming drugs are how you'll live to 150.
even if we cure every disease on Earth, that still wouldn't get you there on its own.
the oldest person who ever lived, jeanne calment, made it to 122, and in almost 30 years nobody has come close to beating her.
120 is just the natural human limit.
so while curing diseases can keep you healthy right up to that limit, it can't actually extend the limit.
but what if you treated aging *itself* as a disease, and cured that?
that's exactly what brian armstrong's company just raised $435M to do.
NewLimit is working on something called cellular reprogramming.
in plain terms, every cell carries a set of instructions that decide how young or old it behaves
NewLimit uses RNA to switch on the combinations that make an old cell start acting young again.
they already have a prototype that does this to human liver cells, healing the liver faster after injury and speeding up recovery from alcohol damage.
the first human trial is set for 2027.
now, to be clear, solving aging is unfathomably hard.
this first liver drug is one cell type in one organ, and reversing aging across an entire body is a much bigger problem than repairing the liver.
but the reason it's even on the table now is AI.
there are more possible combinations of those cellular instructions than any human could test by hand in a billion years
but machine learning is what lets you search that space and find the few that actually make a cell young again.
that's the bet NewLimit is built on.
so the liver is the proving ground. once you can safely reset the age of human cells there, 120 stops being a fixed ceiling.
cellular reprogramming is the real path to 150, and if you can keep resetting the clock, there's no obvious reason it has to stop there...