FairlieLab

The Fairlie group works at the interface of chemistry, biology and disease.

[FairlieLab @FairlieGroup]

Sulfated bile acid is a host-derived ligand for MAIT cells. Ito E, Inuki S, Izumi Y, Takahashi M, Dambayashi Y, Ciacchi L, Awad W, Takeyama A, Shibata K, Mori S, Mak JYW, Fairlie DP, Bamba T, Ishikawa E, Nagae M, Rossjohn J, Yamasaki S.
Sci Immunol. 2024 Jan 26;9(91):eade6924.

[FairlieLab @FairlieGroup]

Professor David Fairlie awarded NHMRC Development grant for developing a new type of drug for inflammatory lung disease. #medicinalchemistry #lunginflammation #allergicasthma #pulmonaryfibrosis #COPD #FairlieLab

[FairlieLab @FairlieGroup]

New paper published:
"HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages".
January 17, 2023
120 (4) e2212813120
https://t.co/yZaG5C5Q9U

[FairlieLab @FairlieGroup]

Welcome back to Damica Laurie who is returning to the Fairlie Group as a PhD student. Damica recently completed her Honours Degree (achieving First Class Honours) with us.

[CIPPS @ARC_CIPPS]

That’s a wrap on #CIPPS2022 👏

Thank you to everyone who made it such a fantastic meeting! We feel so inspired by the great peptide and protein science that was shared and we can’t wait to see what’s next 👀

[CIPPS @ARC_CIPPS]

Now we have @FairlieGroup speaking about strategies for programming peptides for cell permeability and bioavailability

If we could reliably get peptides into cells and send them to specific targets, the application possibilities would be endless!

#CIPPS2022

[CIPPS @ARC_CIPPS]

Day one of #CIPPS22 has started with a wonderful welcome to country from Uncle Allen Madden, Gadigal elder

Always was, always will be.

[CIPPS @ARC_CIPPS]

All set for our first annual conference #CIPPS22 in Sydney 🎉🎉

We are looking forward to a great program of talks and networking! 🗣🎙

[FairlieLab @FairlieGroup]

New Fairlie group paper: Helical structure in cyclic peptides: effect of N-methyl amides versus esters https://t.co/LvkmIHPigq

[Shiao Chow @SYC_Chm]

Very happy to share that I have joined @StrathChem as a Chancellor's Fellow at @UniStrathclyde! Immensely thankful for the support from my mentors: @FairlieGroup, Odell Group @uppsalauni, @Adam_S_Nelson, @BOOMchemistry and @patton_lab!

[StapledPeptidePapers @Peptidepapers]

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake https://t.co/jIyEs3GYop

[Huy Thien Nguyen @HuyThienNguyen]

Great to see this paper on stapled peptides out in RSC Chemical Biology. Glad to have played a small part in this work from my time @FairlieGroup.
We investigated how crosslinks affect helicity, protein affinity, proteolytic stability and cell uptake.
https://t.co/viJPsTNF3R

[FairlieLab @FairlieGroup]

Professor David Fairlie was again listed as a highly cited researcher on the Web of Science. Full list:

https://t.co/dUt57ynNw4

[FairlieLab @FairlieGroup]

Prof. David Fairlie awarded NHMRC Investigator Grant for discovering drugs that target key protein-protein interactions in cancer, metabolic and inflammatory diseases.

[Jeffrey Mak @JeffreyYWMak]

Pleased to share our new paper - a review on our synthesis and development of ligands that modulate #MR1 and #MAIT cells in Accounts of Chemical Research @ACSPublications @FairlieGroup @IMBatUQ @CellsMait #ozchem

https://t.co/ZcVVkz7rhu

[FairlieLab @FairlieGroup]

New Fairlie Group paper makes the cover of ChemBiochem. Late-Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021)
Dr. Aline D. de Araujo, Huy T. Nguyen, Prof. David P. Fairlie
First published: 19 May 2021 https://t.co/mBG11GN26B

[FairlieLab @FairlieGroup]

Our new #MR1 study with H McWilliam & J Villadangos, via new tools and techniques incl. a stable fluorescent ligand, conformation specific Ab, and genome-wide CRISPR screen #MAIT #ozchem @FairlieGroup @IMBatUQ @ImagingCoE
@TheDohertyInst @Bio21Institute
https://t.co/bCPu8XxrkO

[FairlieLab @FairlieGroup]

@MartinStoermer glacé icing. 🙂

[FairlieLab @FairlieGroup]

New research from
@FairlieGroup
shows the potential of a new inhibitor combination in the fight against #cancer. #IMB #2020IMB

Discover more: https://t.co/9t7s9jZ1aB

[Institute for Molecular Bioscience @IMBatUQ]

New research from @FairlieGroup shows the potential of a new inhibitor combination in the fight against #cancer. #IMB #2020IMB

Discover more: https://t.co/rV7YT7M6Zk