Fanuel AT

General Surgeon

[Fanuel AT @FanuelMd]

A lot has to be done on creating awareness among adults on lifestyle changes like reduce sugar, salt and alcohol consumption; regular physical exercise; adherence to medications and follow-up; cessation of smoking; and regular health check ups.

[Fanuel AT @FanuelMd]

ነፍስ ይማር 😥😥😥
It is time for @FMoHealth to do more work on noncommunicable diseases like diabetes mellitus, hypertension, obesity and cancer.

[Fanuel AT @FanuelMd]

@BradleyCarlUtd 😂😂😂😂😂😂😂😂😂😂😂😂😂

[Aakash Gupta @aakashgupta]

This isn’t a random scientist who got lucky.

Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.

KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.

The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.

Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.

The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.

Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.

[Fanuel AT @FanuelMd]

Hehehehe #ARSvsMUN

[Fisseha Tegegn @Fisseha_Tegegn]

This result will make Man United fans realise there is nothing special about beating the current Man City side…

[Fanuel AT @FanuelMd]

@LiamPaulCanning Xavi

[Fanuel AT @FanuelMd]

@LiamPaulCanning A new manager.

[Fanuel AT @FanuelMd]

@UtdForever7 @ManUtd @premierleague No!

[Fanuel AT @FanuelMd]

@unitedupdates Out tomorrow morning!

[Fanuel AT @FanuelMd]

@LiamPaulCanning He should go otherwise we can say goodbye to European football next season. And no champions league means more damage to the club.

[Fanuel AT @FanuelMd]

@LiamPaulCanning When is the club going to realise this wanker is here to ruin lives 😭😭😭

[Fanuel AT @FanuelMd]

@RealistGlizzy Club will never succeed under this wanker. He knows his system is not going to work for over a year but he is stubborn to adapt. The bald guy was much better 😡😡😡

[Fanuel AT @FanuelMd]

@unitedupdates OUT!

[Fanuel AT @FanuelMd]

@centredevils YES!

[Fanuel AT @FanuelMd]

@MattyFC__ People didn't notice it yet but Casemiro is the pillar of this team. Two of the games we lost, uncle Case didn't play. Let's pray he doesnt get injured or suspended because no player can replace him from the squad.

[Fanuel AT @FanuelMd]

@LiamPaulCanning I'd sack him today! This guy will relegate us if given more time.

[Fanuel AT @FanuelMd]

😊😊😊 Is there a better art than this?

[Khanyisile Jamani @Jamani_Khanyi]

One thing about Doctors 🥹❤️🙌🏾🙏🤞🏽

[Fanuel AT @FanuelMd]

@UTDTrey I can't stop laughing 🤣🤣🤣🤣🤣🤣

[Fanuel AT @FanuelMd]

Surgeon catches CANCER from patient in first-of-its-kind case

https://t.co/ydaSRjPFB1

[Fanuel AT @FanuelMd]

@sampilger Exactly!