The Ferraiuolo Lab

Researching glia in neurodegeneration and ageing. We are based at Sheffield Institute for Translational Neuroscience (SITraN).

[The Ferraiuolo Lab @FerraiuoloLab]

Take a moment to read our new findings on how endothelial cells forming the blood brain barrier can affect motor neurons in #mnd #als ⁦@AnaAragonG⁩ ⁦@neuroshef⁩ ⁦@ENeurotrophin⁩ https://t.co/6YPqKbXQTe

[BenevolentAI @benevolent_ai]

#BenevolentNews: Pleased to announce that we have progressed BEN-34712 into IND-enabling studies.

BEN-34712 is an oral, potent and selective brain penetrant RARɑ𝛃-biased agonist being developed for the potential treatment of #ALS.

Read more → https://t.co/yJJvB7qyYo

[Laura @LauraFerraiuolo]

Supporting studies that progress to this point and beyond is why I dedicated my life to neuroscience and #MND #ALS research. So proud to have worked on this with @Richard_Mead @FerraiuoloLab @benevolent_ai @neuroshef

[Cleide Souza @CleideNeuro]

For those who needs to see some Striatal Medium Spiny Neurons in this beautiful sunny day.
Have a good weekend everyone.
#StemCell #neuroscience

[Selina Natalie Beal @SN_Beal]

Thank you @pintofscience for hosting a great event! A great evening presenting our work with @MartynaMatuszyk @DrMarianneKing and Tania! As always the support from @FerraiuoloLab is amazing so proud to be a part of this team! ❤️ #PintOfScience #research #MND

[Cleide Souza @CleideNeuro]

Very interesting talk from @AstroMysz #Pint23

[The Ferraiuolo Lab @FerraiuoloLab]

2023 Rob Burrow Leeds Marathon https://t.co/ZEL5ZkfYUK

[The Ferraiuolo Lab @FerraiuoloLab]

Our embryoid bodies that we use for our cocultures are looking especially bright and green today! We should get beautiful motor neurons from these, which we will use to test different drugs to see if they can prevent the motor neurons from degenerating. #Cellfie #MND #MNDresearch

[Cleide Souza @CleideNeuro]

For those who need to see Motor Neuron today. Happy Friday. #neuroscience #stemcells @neuroshef

[The Ferraiuolo Lab @FerraiuoloLab]

Some beautiful cells to brighten up your Saturday! Here we have some neuronal progenitor cells derived from induced pluripotent stem cells, stained for Pax6 and Nestin (NPC markers).

[Leeds Centre for Disease Models @DIMOLeeds]

Fantastic first talk delivered by @LauraFerraiuolo about modelling MNS in astrocytes. Very cleaver fast track differentiation from fibroblasts to cells of interests 💨🧫

[Leeds Centre for Disease Models @DIMOLeeds]

We have fantastic external speakers including @LauraFerraiuolo, John Greenman and Michele Zagnoni. We will also have our internal disease models experts speaking including @Basudha_Basu, Elizabeth Roundhill and @SalPeyman 🤩🤩🤩

[Ammar Al-Chalabi @AmmarAlChalabi]

30 years ago today the first cause of #ALS #MND was found by Prof Robert H Brown Jr and his team. Now we have a genetic therapy, Tofersen, that looks to have a dramatic effect in the 2% carrying this gene variant. A small step that shows ALS can be defeated with the right tools.

[The Ferraiuolo Lab @FerraiuoloLab]

Honoured to be part of this study that furthers our understanding and gets us closer to potential treatments for #MND A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins https://t.co/NDpplA6M8s

[LeMND24 @LeMND24]

@MNDoddie5 @burrow_geoff . Could you please follow and retweet. We are attempting a world record to raise funds and awareness of MND. https://t.co/AOCQ4nzlpr

[The Ferraiuolo Lab @FerraiuoloLab]

Friday in the lab: neurons are @CleideNeuro's priority, everyone else can wait.
Photo courtesy of @DrMarianneKing.

[The Ferraiuolo Lab @FerraiuoloLab]

@J9Kirby you can bet!

[The Ferraiuolo Lab @FerraiuoloLab]

Well done All! Great job @Raquel_RMartins

[Ana Aragón-González @AnaAragonG]

Happy to share an online entry about "Components of the Blood–Brain Barrier", adapted from our recent review article https://t.co/pgWpG4kPmA ,
at the free and open platform for researchers @EncyclopediaMD1
https://t.co/1EpwC4WOFX
🧠Go have a look!
@FerraiuoloLab
#OpenScience

[The Ferraiuolo Lab @FerraiuoloLab]

Happy New Year from all of us at Ferraiuolo lab! Here's to a great 2023.
If one of your New Year's resolutions is to keep abreast of our work, our website is a great place to start.
https://t.co/2OhkMXMNqA