Fiedlerlab

Twitter account of the Fiedler group. (student handled)

[Fiedlerlab @FiedlerLab]

We would also like to thank all the people involved in this study. @MRuwolt @theliulab @JeremyAMMorgan

[Fiedlerlab @FiedlerLab]

During our investigation of protein pyrophosphorylation, we identified a novel post-translational modification (PTM), which we have termed 'Protein Oligophosphorylation'.
https://t.co/dFOJilk9kh

[Fiedlerlab @FiedlerLab]

To substantiate our findings, we collaborated with @PhosphorusFive @CEStieger and @daniel_roderer @FelixSchoepf to obtain mass spectrometry spectra and the first-ever Cryo-EM structure of pyro-and oligo- phosphorylated proteins.

[Fiedlerlab @FiedlerLab]

https://t.co/dCbSE1LccD

Pyrophosphorylation „In the Pipeline“ :)

[Fiedlerlab @FiedlerLab]

Happy to share our latest paper on protein pyrophosphorylation - yes, it exists! It has been a long journey with many wonderful co-workers and collaborators. Thank you all!
@JeremyAMMorgan @MRuwolt

https://t.co/DE4CFdPuQD

[Fiedlerlab @FiedlerLab]

Together with the paper checkout this „News&Views“ article about the „Pyrophosphomania“!

https://t.co/lwNqpQK47o

[Fiedlerlab @FiedlerLab]

@chemzymes Thats an interesting suggestion! Our lab has done a study on a similar line in the past: https://t.co/QwrWrwKpK0

Maybe this helps to answer your question partially! Enjoy the read!

And you are absolutely right the pyrophosphomania has just begun 🌊

[Fiedlerlab @FiedlerLab]

Follow up to our discovery of endogenous protein pyrophosphorylation, Arif Celik, a PhD student from our lab, decided to select one of the newly found „pyrophosohoproteins“ and see what effect does this PTM have on protein activity.
https://t.co/Z5bDJl5h4d

[Fiedlerlab @FiedlerLab]

On the way to understanding the role of pyrophosphorylation, he also discovered a new mode of protein pyrophosphorylation! Thank you Arif for the hard work!

[FMP Berlin (now on Bluesky) @LeibnizFMP]

📢Vortrag: Wer quasselt da? Wie Zellkommunikation funktioniert, Prof. Dr. Dorothea Fiedler @FiedlerLab
Für Lehrkräfte, Schüler:innen & Wissbegierige
📍 Kinosaal des Zeiss-Großplanetariums,Berlin
🕓16 Uhr, 7. Nov. Eintritt: Kostenlos!
📝 [email protected]
#BerlinSciWeek

[Fiedlerlab @FiedlerLab]

After a lot of efforts from our former post doc Sarah Hostachy, we are do happy to see this out!

[ChemEurJ: Chemistry - A European Journal @ChemEurJ]

Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs (Dorothea Fiedler and co-workers) @FiedlerLab @LeibnizFMP https://t.co/t5HTNDKnH3

[Fiedlerlab @FiedlerLab]

Thank you all the coauthors for their contribution!
@GilleighD @VolkerHaucke

[Fiedlerlab @FiedlerLab]

Unexpected results often lead to fascinating discoveries!
Have a look at this new paper from our lab where @timaguirre_chem developed an inhibitor for IP6Ks and found out some really cool mechanistic details about the inhibition

https://t.co/DnOwacNXMI

[Fiedlerlab @FiedlerLab]

And it ends with a very rainy ride back to Berlin!

[Fiedlerlab @FiedlerLab]

The group retreat begins with a ~ 40 km bike ride thru a beautiful forest! 🚵‍♀️🚵🚵‍♂️

[Fiedlerlab @FiedlerLab]

After the amazing bike ride and an even better scientific session, it was barbecue time :)

[FMP Berlin (now on Bluesky) @LeibnizFMP]

📢Exciting talk alert! Maja Köhn @MAJAFL @UniFreiburg will delve into "Function, selectivity & chemical targeting of protein phosphatases.”
This Friday, September 29th, 3:00 pm. Join us on Zoom! Meeting-ID: 963 0761 9443, Kenncode: 550079
#ScienceTalk @PhosphorusFive @FiedlerLab

[Gabriel Schaaf @GabrielSchaaf]

Congratulations to Minh Nguyen Trung @FiedlerLab for a wonderful defense of his PhD "Elucidation of Inositol Polyphosphate Dephosphorylation Pathways using Stable-Isotope Labelling and NMR spectroscopy" What a journey! Grateful to have been part of the evaluation committee🍾🥞😀

[Fiedlerlab @FiedlerLab]

Congratulations Minh for successfully defending your PhD! A very well deserved “summa cum laude” and thank you so much for contributing towards unveiling of the black box of inositol polyphosphate metabolism :)