Let’s tear down the fantasy vs. reality for $MRNA
The Bull Math (The Trap):
• 120k US melanoma cases × $100k/tx = $12B TAM
• 20% net margin = $2.4B profit • 50/50 split with $MRK = $1.2B to Moderna
• 400M shares = +$3.00 EPS• “Easy multi-bagger ,right?!”
The Clinical & Commercial Reality:
Grossly exaggerated TAM:
Intismeran is ONLY for resected high-risk Stage IIB–IV melanoma. That’s ~22k US patients/year, NOT 120k. 80% of melanoma is early Stage 0/I cured with a scalpel in 15 minutes.
Real-world peak penetration: At 40% adoption of the eligible pool, that’s ~9k patients = $900M gross revenue, not $12B.
The net earnings haircut: At a generous 20% margin (bespoke mRNA sequencing & cold-chain logistics aren’t cheap):
• Total program profit: $180M
• $MRNA’s 50% cut: $90M
• Actual EPS contribution: +$0.23 (on ~400M shares)
You won't see meaningful commercial revenue until 2029 at the earliest. Even with late-stage data, regulatory filings, PDUFA reviews, reimbursement coding, and commercial ramp-up take years.
You are waiting until nearly the end of the decade, absorbing clinical & regulatory execution risk, all to net under a quarter per share in melanoma.
So .si is 1/2 their revenue, >$7bn. Meh.
Leaves their core businesses - space program & StarLink at $7bn in revenue. That’s horrific.
This isn’t a real company; it’s a mirage in the desert for people willfully ignorant enough to drink the sand & thank you for the water.
@Mr21318@ellerby_dave@80milePLC Yeah I’ve been trying to scenario test the GLND stock price given the scenarios that could occur, but seems to be too many variables this far out from the confirmation
$GLND $GEOM
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