Gabriel Fitzgerald

Principal Scientist - In Vitro Pharmacology @ Tenvie Therapeutics

[Alzforum @alzforum]

To turn obese mice into trim ones, Tenvie’s NLRP3 inhibitor enters the brain, where it cools down an inflamed hypothalamus. https://t.co/AUGtxE24tL

[Cell Reports @CellReports]

Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactions https://t.co/AlvjW9GsLT

[Tenvie Tx @TenvieTx]

Thrilled to launch @TenvieTx with
a commitment to transform
the treatment of neurological
diseases!

Check out our PR: https://t.co/AvvwpSot3C

[Alzforum @alzforum]

Scientists may have discovered why ApoE4 causes Alzheimer’s disease and ApoE2 prevents it. Hint: the reasons are different. @Denalitx https://t.co/i9vWE6CdDR

[Gabriel Fitzgerald @Fitzgerald_G_A]

First paper from my time at DNLI out. Congrats to all the coauthors!
https://t.co/vJ4EponZ4w

[Cell Biology J-Club @cell_club]

Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles | PNAS https://t.co/swuMMh3DJv

[memprotbiophys @memprot_biophys]

A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities https://t.co/fE6G1pXjrr

[Keith Hornberger @KRHornberger]

To begin, the data we have that forms our understanding of biology is woefully incomplete and flawed, so the AI training set is too. Even with all the compute power in the world, the model you build can’t be much better than the data you feed it. 2/

[André Nadler @nadlerlab]

Together with the @zechnerlab we have pushed live-cell quantitative lipid biochemistry to the single cell level. It works - but some lipids are weird. 🤓
Great effort by shared 1st authors @davidtgonzales1 and @MMSchuhmacher. Let us know what you think! https://t.co/Ux5fdJxmwe

[Membrane Protein PDB @MemProtPDB]

Uncoupled substrate binding underlies the evolutionary switch between Na+ and H+-coupled prokaryotic aspartate transporters | bioRxiv

https://t.co/rqsvkXuQU9

[David B Sauer @DavidBSauer]

Ceramide Synthase 6 (CerS6) uses a ping-pong reaction mechanism! Found and probed via CryoEM, MD, and MS.

Spectacular work by @TomasPascoa and colleagues from @CmdOxford, @Boehringer (@BoehringerDE), and @UZH_en

https://t.co/rZV8664sd9

[Neurology Advisor @NeuroAdvisor]

High and low levels of HDL cholesterol, but not levels of LDL cholesterol, are associated with an increased risk of developing #dementia in older adults. ➡️https://t.co/ONZMOCeoqd #NeuroTwitter #NeuroX

[John Lukens @LukensJohnR]

TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. https://t.co/l71hUm3cIt

[Cell Biology J-Club @cell_club]

Optogenetic control of lysosome function https://t.co/j9dJK93iE0

[Philipp Schmidpeter @iHeart_proteins]

I will start as Assistant Professor at @UTSA @UTSASciences @UTSAChemistry in August. The motto of the @iHeart_proteins lab will be: "Integrative Protein Physiology - connecting cellular pathways"
Check out our brand new homepage for more details!

https://t.co/kI7KzvgqIz

[Gabriel Fitzgerald @Fitzgerald_G_A]

@iHeart_proteins @WCMAnesthesia @CrinaNimigean @UTSA @UTSAChemistry Congrats on the new position!!

[St. Jude Research @StJudeResearch]

Scientists from St. Jude and @RockefellerUniv integrated structural biology techniques to better understand the cystic fibrosis transmembrane conductance regulator, providing new treatment clues. https://t.co/8dboJpbDmv @TheBlanchardLab #RareDisease @Nature

[Rockefeller University @RockefellerUniv]

Rockefeller's Jesper Levring & Jue Chen & their collaborators at @StJudeResearch share new insights on cystic fibrosis in @Nature: “We've answered a question that has been a subject of debate in the field for many years." #RockefellerScience https://t.co/dehObeNF9W

[Tamir Gonen @gonenlab]

A channel does not transport. So many people make that mistake. Transporters transport. Channels are not transporters.