Fraternali Lab

Bioinformatics & Computational Biology @ University College London @ISMBInstitute @ucl

[Fraternali Lab @FraternaliLab]

New paper alert! 🚨

[Nature Methods @naturemethods]

sciCSR developed by @FraternaliLab, @JosefNg1 and colleagues is a computational workflow that uses scRNA-seq data to predict class switch recombination events and B cell dynamics.
https://t.co/uUWIvey7JJ

[Fraternali Lab @FraternaliLab]

Dongjun & Joseph at #bsi2025 with poster on this! Poster P005

[Fraternali Lab @FraternaliLab]

Belated announcement that ImmunoMatch has now been published in @naturemethods !🎉 AI powered prediction of antibody heavy-light chain pairing with applications in understanding B cell biology and mAb discovery. https://t.co/QacpKuRBiB

[Fraternali Lab @FraternaliLab]

Also check out UCL press release: https://t.co/ZEYpnoC6Qc

[Fraternali Lab @FraternaliLab]

@ffrancafrat @3DSIG_ISCB @iscb

[Fraternali Lab @FraternaliLab]

@ffrancafrat to deliver keynote in the #3DSIG track #ISMBECCB2025 In Liverpool this year! https://t.co/eu7IgpiRPy

[Fraternali Lab @FraternaliLab]

Great talks by both Oriol and Joseph at #ELIXIR #3dBioinfo meeting at Barcelona!

[Josef Ng @JosefNg1]

Another preprint @FraternaliLab: We explored how the antibody framework (i.e. parts of variable region away from Ab-Ag interface) can be exploited to fine-tune antibody effector functions. V enjoyable in vitro/in silico collab @ffrancafrat @SophiaKaragiann https://t.co/ZEujIahqjy

[Fraternali Lab @FraternaliLab]

🚨 New preprint on our new approach (IndeLLM) to score pathogenicity of insertions/deletions https://t.co/Gtekwbg0Mg

[Josef Ng @JosefNg1]

Happy to share new work @FraternaliLab led by @Dongjun_Guo - exploring how antibody heavy and light chains form specific pairs. We fine-tuned an antibody language model to predict pairing, and asked how pairing propensities change during B cell maturation and in diseases.

[Fraternali Lab @FraternaliLab]

Proud to be part of this exceptional mentoring programme💪 @ELIXIREurope

[Fraternali Lab @FraternaliLab]

@ffrancafrat speaking in Copenhagen today about ongoing work on antibodies in the group!

[Fraternali Lab @FraternaliLab]

Joseph on sciCSR to study and infer class switching dynamics in B cells using scRNA-seq data #ISMB2024

[Fraternali Lab @FraternaliLab]

Dongjun's talk on ImmunoMatch a.k.a. antibody "tinder" to study heavy and light chain pairing at 3DSIG! #ISMB2024

[Fraternali Lab @FraternaliLab]

Oriol's talk on addressing biases in variant impact prediction at VarI #ISMB2024

[Mauri Lab UCL @Mauri_group]

Congratulations to Guillem for winning a prize for his poster on double negative/atypical memory B cells in SARS-CoV-2 mRNA vaccination at the @iit_ucl symposium 2024 🎉👏

[Josef Ng @JosefNg1]

We present VCAb, a new web interface for performing different structure-based explorations towards aspects of antibody engineering: 🧵(1/7)
📄https://t.co/qk35islnkH
🌐https://t.co/PUppVtsjuL

[Deborah Dunn-Walters 💙 @beecellnumbers]

Postdoc available in our lab. B cells, antibodies and class switching. Part of a wider BBSRC sLoLa with @FraternaliLab @Mauri_group https://t.co/YkaVogmVwC

[Mauri Lab UCL @Mauri_group]

Well done to Izzy for winning a prize for her presentation on the single cell analysis of B cells in lung cancer!!👏🫁🧬#WIRM

[Fraternali Lab @FraternaliLab]

Xmas gift 🎁 came early for us: New review came out on @COSB_CRSB where we talked about structures of different antibody isotypes & how to model and study them! Feat. a great deal of fun drawing antibodies in the style of ladders and snakes! Free access at
https://t.co/7BEZGSLo14

[Fraternali Lab @FraternaliLab]

Xmas outing feat. a walk across Hertfordshire countryside on a cold wintery day followed by pub!