Fulka Lab

We are the Department of Cell nucleus plasticity, a part of Institute of Experimental Medicine of Czech academy of Sciencies.
#oocyte #nucleolus #chromatin

[Fulka Lab @FulkaLab]

Leaving the lab for leadership is a tough shift for scientists. We’re trained in data, but people management requires a completely different operating system. Engagement metrics reveal issues, but learning to structure teams effectively closes the gap. #Leadership #Science

[Ramiro Alberio @AlberioRamiro]

📢We are looking for a motivated reseacher to join our in vitro gametogenesis program. If you are interested in germ cell biology, click on the link for more details: https://t.co/JRf3xAnmDw #stem #gametogenesis #notinthegenes

[Fulka Lab @FulkaLab]

@zaffagg3 Super-weird! 🤨

[Fulka Lab @FulkaLab]

Exam season is here. Good luck to everyone! We, as teachers and examiners, do our best to help, but every so often things still don't go as planned... #ExamSeason #GoodLuck

[Fulka Lab @FulkaLab]

Can cycloheximide cause DNA damage? Possibly. Inhibiting protein synthesis stresses cells and raises DNA‑damage markers like γH2AX — but are these actual DNA breaks or is it just induction of markers? #CellBiology #DNA

[Fulka Lab @FulkaLab]

When you can't replicate published results, self-doubt sets in: why isn't it working? What´s wrong? In desperation, you start optimizing with what you have. Glad we did! We learned a lot, and now we´re looking forward to the key experiment. Exciting! #CellBiology #OocyteResearch

[Fulka Lab @FulkaLab]

@euvlook Well, the biggest nightmare so far was to try to replicate some of the published data. No idea if we are not doing it right or what (maybe a diffent mouse, maybe different culture...).

[Fulka Lab @FulkaLab]

How do oocytes handle DNA damage when transcription is shut down? What I thought would be a small, fun project has ballooned into a nightmare of endless variables. Science really isn’t all sunshine and rainbows. #CellBiology #ReproductiveBiology #futureART

[Fulka Lab @FulkaLab]

Bovine oocytes and embryos closely mirror human ones and are vital to reproductive research, yet they are notoriously challenging to handle. Many thanks to our colleagues in the Department of Reproduction at the Institute of Animal Science. #ReproductiveScience #AnimalScience

[Fulka Lab @FulkaLab]

We are thrilled to be part of the ART FOR THE FUTURE project, aiming to explore new frontiers, from AI and germ cells in vitro to ethical or legal issues, bridging basic science and clinical practice. More: https://t.co/hlOqTSxVCL

#futureART #Strategie_AV21 #ReproductiveMedicine

[Fulka Lab @FulkaLab]

Check out these beauties! Our advanced-maternal-age oocyte media has produced its first embryos. It's both exciting and nerve-wracking, but I love every moment! 🤩 #Embryology #Innovation

[Fulka Lab @FulkaLab]

How can we tackle issues like DNA damage or mitochondrial dysfunction in embryos? By intervening before the first embryonic replication, we can prevent these issues from becoming permanent, ensuring healthy development. Read more: https://t.co/rjPwWCGycu #Genetics #Embryology

[Fulka Lab @FulkaLab]

@zaffagg3 @Bims_BiomedNews PhD forever? 😁

[Fulka Lab @FulkaLab]

@TakashiAkeraLab Super-excited to hear your talk!

[Fulka Lab @FulkaLab]

Curious about why some genes are favored in the egg during meiosis or how selfish genetic elements break Mendel's rules? Join us on April 2nd at the Institute of Experimental Medicine to learn more! #Genetics #Meiosis #ScienceEvent

[Fulka Lab @FulkaLab]

Ever wondered about the function of nucleoli in zygotes and early embryos, and their interaction with the embryonic genome? Mark your calendars! #Embryology #Genomics

[Fulka Lab @FulkaLab]

It took me a while to realize that signs of oocyte aging aren't uniform (why would they be, right?): Two mouse strains, similar in age, completely different spindle traits. How much does this apply to human individuals? #OocyteAging #GeneticDiversity

[Fulka Lab @FulkaLab]

@BoianiMichele Congratulations! Nice paper!

[Michele Boiani @BoianiMichele]

After sharing the advanced publication access few weeks ago, I am now pleased to share the final typeset version, open access, of my group’s latest contribution in Molecular Human Reproduction
https://t.co/8jWQQnYxng
In a nutshell, we report that the first two blastomeres are reciprocally different in terms of epiblast production, for reasons that seem to depend on the site where the spermatozoon penetrated the oocyte, in mice. Our half-cell proteomics data supports that this difference is possibly due to heterogeneities in ooplasm composition and how they are apportioned into the blastomeres depending on the orientation of the first zygotic division. Thanks to the co-Authors, to the Reviewers, to the Journal, and I hope you like the paper!