@GI

Tweets of interest to gastroenterologists and the GI community -- team led by Dr. Rajat Chander (M.D., Duke, B.A. Columbia (NYC) comp sci)

[Samuel Hume @DrSamuelBHume]

One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results

I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

[@GI @GI]

Wonderful to see communities and health systems come together to create 3 new medical schools in just a few years, will expand health services throughout the state.

North Carolina’s Medical School Boom https://t.co/VpxywLO45x

[@GI @GI]

Amanita phalloides mushroom poisonings in California, incidence uptick due to rains
https://t.co/R7UoMG23mG

[@GI @GI]

Tremyfa, Rinvoq and Dupixent commercials all 3 on NBC Prime Time tonight. Such ads have a powerful influence on patients' acceptance of these biologics.

[Bo Wang @BoWang87]

Pancreatic cancer has one of the most suppressive tumor microenvironments in oncology.

But two pancreatic cancer results dropped today. Both matter.

1. BioNTech mRNA neoantigen vaccine: nearly all responders still alive at 6 years. 98% of induced T cells were de novo — the immune system learned to see a cancer it had always been blind to.

2. Daraxonrasib: 47% ORR, 92% disease control as first-line monotherapy. KRAS G12D, undruggable for 40 years, finally has a drug.

Different mechanisms. Same disease. Both working.

<13% of patients survive 5 years. That number is about to change.

great day for science! 🔥

[Aaron Ring @aaronmring]

Every oncologist and cancer researcher should watch this interview with @BenSasse:

https://t.co/PeTl9Eg1g8

Daraxonrasib, a “super poison for cancer,” shrank his metastatic pancreatic tumors by 76%, even though he says his skin feels and looks “nuclear.” When I learned of his diagnosis, I wanted him to get this drug (oral RAS ON inhibitor), which is poised to become first-line therapy in pancreatic cancer. I hope his experience on a clinical trial encourages more patients to enroll in studies, and pushes clinicians and researchers to keep advancing new therapies.

[Massimo @Rainmaker1973]

An inside view of the vocal anatomy and how it produces sound

[📹voice_with_natalia]

[@GI @GI]

@ColonCancerCoal will help you find a 5k walk/run fundraiser for colon cancer prevention. Cancer survirors and healthcare nurses and doctors from across town and from different health systems -- all aligned on the same mission.

https://t.co/nXXzH5JIig

[@GI @GI]

Could AI bring similar layoffs to healthcare? Perhaps not in direct patient care, but more on back end financial and documentation work.

It's also possible that AI first clinics are coming sooner than we think.

[jack @jack]

we're making @blocks smaller today. here's my note to the company.

####

today we're making one of the hardest decisions in the history of our company: we're reducing our organization by nearly half, from over 10,000 people to just under 6,000. that means over 4,000 of you are being asked to leave or entering into consultation. i'll be straight about what's happening, why, and what it means for everyone.

first off, if you're one of the people affected, you'll receive your salary for 20 weeks + 1 week per year of tenure, equity vested through the end of may, 6 months of health care, your corporate devices, and $5,000 to put toward whatever you need to help you in this transition (if you’re outside the U.S. you’ll receive similar support but exact details are going to vary based on local requirements). i want you to know that before anything else. everyone will be notified today, whether you're being asked to leave, entering consultation, or asked to stay.

we're not making this decision because we're in trouble. our business is strong. gross profit continues to grow, we continue to serve more and more customers, and profitability is improving. but something has changed. we're already seeing that the intelligence tools we’re creating and using, paired with smaller and flatter teams, are enabling a new way of working which fundamentally changes what it means to build and run a company. and that's accelerating rapidly.

i had two options: cut gradually over months or years as this shift plays out, or be honest about where we are and act on it now. i chose the latter. repeated rounds of cuts are destructive to morale, to focus, and to the trust that customers and shareholders place in our ability to lead. i'd rather take a hard, clear action now and build from a position we believe in than manage a slow reduction of people toward the same outcome. a smaller company also gives us the space to grow our business the right way, on our own terms, instead of constantly reacting to market pressures.

a decision at this scale carries risk. but so does standing still. we've done a full review to determine the roles and people we require to reliably grow the business from here, and we've pressure-tested those decisions from multiple angles. i accept that we may have gotten some of them wrong, and we've built in flexibility to account for that, and do the right thing for our customers.

we're not going to just disappear people from slack and email and pretend they were never here. communication channels will stay open through thursday evening (pacific) so everyone can say goodbye properly, and share whatever you wish. i'll also be hosting a live video session to thank everyone at 3:35pm pacific. i know doing it this way might feel awkward. i'd rather it feel awkward and human than efficient and cold.

to those of you leaving…i’m grateful for you, and i’m sorry to put you through this. you built what this company is today. that's a fact that i'll honor forever. this decision is not a reflection of what you contributed. you will be a great contributor to any organization going forward.

to those staying…i made this decision, and i'll own it. what i'm asking of you is to build with me. we're going to build this company with intelligence at the core of everything we do. how we work, how we create, how we serve our customers. our customers will feel this shift too, and we're going to help them navigate it: towards a future where they can build their own features directly, composed of our capabilities and served through our interfaces. that's what i'm focused on now. expect a note from me tomorrow.

jack

[@GI @GI]

Screening with once-only colonoscopy and screening with two rounds of FIT, with a low cutoff of 10 μg Hb/gr. Both arms of SCREESCO [Screening of Swedish Colons] found earlier colon cancer vs control. HT @EricTopol

https://t.co/7p161cmB5u

[@GI @GI]

This is great use of AI. The difference may be that doctors take ownership of those labs to keep patients safe.

[Elon Musk @elonmusk]

You can just take a picture of your medical data or upload the file to get a second opinion from Grok

[@GI @GI]

At the North Carolina Society of Gastroenterology conference. With Dr Nick Shaheen moderating.

The four horsemen of heartburn- biopsy, esophagram, pH, and manometry. And gastric emptying as the fifth horseman!

[@GI @GI]

Delighted to note such progress with treating SCID. https://t.co/NVrgVBnrHF

[Daniel Park @danifesto]

I’ll share a small part of https://t.co/UQ4RFIKUwO

Back in med school, I became obsessed with augmenting memory and dreamed of a Notion or Obsidian that completes itself. Today, we’ve built something close.

My self-awareness is sharper and everything feels connected. I genuinely believe AI does not replace humans. It amplifies us.

Huge respect to our engineers and designers who made this crazy thing real.

Bubbles are the episodic units of my life that the system interprets from my raw data. Clouds are the system’s questions, its hypotheses about who I am.
When I answer a cloud, it becomes a bubble again.

There is so much personal data that I cannot fully demo it. Wish I could. This system understands me more deeply than anyone.

Want to try it? Retweet and comment “memory.”
I’ll DM you an access code to skip the waitlist.

[@GI @GI]

"Think deeper, doc, that's what GPT-5 does!" Next time when a patient is waiting for a diagnosis.

You can feel the rules of the profession changing.

@OpenAI

[@GI @GI]

7 tips for physicians to engage Congress during August recess https://t.co/OIOyz9qXKm (via @AmerMedicalAssn)