MD, Consultant Gastrointestinal Oncology and Gastroenterology, Universitair Ziekenhuis Leuven | Colon Cancer research at Tejpar lab | @UZLeuven @KU_Leuven
🚨 STELLAR-303 makes history! First-ever Ph3 trial to show OS benefit of IO in MSS CRC 🎯
Years of grit & belief led us here 🥹
Endless thanks to Exelixis for the trust & Dr. Hecht for leading this global win with me! 🎉 @UPMCHillmanCC https://t.co/qLG56BiBmc
Effect of a daily scrum at the GI oncology ward on length of stay: A tertiary center experience
💡 This year, we also have an (online) #ASCO25 abstract in 'Care Delivery and Quality Care'.
🤔 How can we reduce length of stay for our GI onc patients?
@UZLeuven@ASCO
🧐 Can you predict who’s responding to #BOTBAL and who isn’t? Discover it next week at #ASCO25!
🙋♂️ See you on:
Saturday 31st of May, 09:00AM to 12:00PM #CRC poster session, Hall A
Poster Bd 196 - Abstract No 3527
@UZLeuven@KU_Leuven@OmniscopeAI@Agenus_Bio@ASCO
Looking back at a fruitfull 2 days at the @EORTC GI tract cancer group ‘spring meeting’ that we hosted at @KU_Leuven. The first day was all about academic research collaboration. While today we had a scientific symposium on the #neoadjuvant space in GI cancers.
@FilipHerpe
First patient dosed worldwide today in #AZUR4 at @UZLeuven 🌎🏅
While the exact relevance of #pCR as a surrogate endpoint remains an important question for debate, still, very curious where we will land. Time will tell. ⏰🤔
#pMMR#MSS#CRC@LKILeuven
🚨Highlights from #ASCOGI2025! Dr @GJRas unveils key advances in colorectal cancer. From immunotherapy breakthroughs to predictive biomarkers and preventive strategies, catch all the latest insights.
🚨Poster from #ASCOGI2025! Dr @GJRas presents a novel IS-IC model to predict ICB response in mCRC.
🔹 High-score groups show ICB-sensitive stroma.
🔹 Multiplex immunofluorescence confirms biomarker validity.
Immunosensitivity cuts across mismatch repair status in colorectal cancer
Our preview article on the recent Acha-Sagredo et al. has been published today in @Cancer_Cell.
https://t.co/FGK8lgHQJ7
🎆 Now online - my 2 fav topics in one paper
👍FOxTROT Ph2 FOLFOX+/- pani in locally advanced RAS/RAF-wt colon cancer
👍Convincing activity of anti-EGFR on long term outcomes, esp in hyperselected pts
❓Time to re-think targeted agents in LACC/LARC
https://t.co/wDhAkgCYw5
We have compared the performance ctDNA by Natera vs. imaging in curatively resected colorectal cancer on surveillance. Signatera missed 31% of recurrences (+ imaging and negative Signatera). Largest study of comparative strategies. https://t.co/slg6r2Qvsm
Exciting times ahead! Happy to see our passion project getting off the ground. Let’s explore immuneresponsiveness in the NA setting for pMMR/MSS CRC.
Next to a couple top sites in UK, Spain & Swiss, AZUR-4 will especially run at our Belgian NA platform with 10 partners in crime!
Where innovation crosses boundaries! Final countdown has started! If you haven’t registered yet, register today! Looking forward welcoming you soon in Leuven for our International Congress! @ibdleuven@SeverineVermei1@JoaoPGSabino@DhooreAndre@bisle84
https://t.co/1h2859p3cM
2/2 However still real-world study... Hetererogenous small population (N= 22) both dMMR/MSI & pMMR/MSS tumors. Not clear who received ICB only, who received combination with chemotherapy.
Future prospective studies are coming!
@Cancer_Cell@CellCellPress@PKU1898
1/2 Very interesting work by Zemin Zhang and esteemed colleagues tracking immune dynamics of #CRC patients under PD-1 blockade.
https://t.co/SYgigqxvUc