GLP-1 LIFE!

GLP-1 LIFE! is your daily dose of motivation, science, and real-world wins powered by the transformative potential of GLP-1 medications.

[GLP-1 LIFE! @GLP1_LIFE]

#EliLilly $LLY #zepbound #Mounjaro
https://t.co/T5504qfgQ0

[Eli Lilly and Company @EliLillyandCo]

Today, the FDA approved Lilly's new oral treatment for people with ESR1-mutated #BreastCancer, which targets two key drivers of ER+ breast cancer. Learn more: https://t.co/WV6BPSsB91

[GLP-1 LIFE! @GLP1_LIFE]

Living the GLP-1 Life
https://t.co/jpgzK7UvYq

[GLP-1 LIFE! @GLP1_LIFE]

The Scientists Behind Retatrutide Just Removed
#GLP1 . Weight Loss Was Still Massive.
But What Else Are We Removing With GLP-1?
https://t.co/woBh0Pc1ml

[GLP-1 LIFE! @GLP1_LIFE]

#Novo $NVO and #EliLilly $LLY Weight-Loss Drugs Still Work at Smaller Doses, Study Finds #zepbound #wegovy
https://t.co/daKqqkO8H8

[GLP-1 LIFE! @GLP1_LIFE]

@JCanNuSH @DemocratusMagna Thanks!

[GLP-1 LIFE! @GLP1_LIFE]

#Reta #Retatrutide #Tirzepatide #Semaglutide #Peptides #GrayMarket #GreyMarket #SS31 #BP157 #KLOW
https://t.co/Umy1HaT7UK

[James | 9th Life @James9thLife]

Woah this is really cool...

A Korean research group just published preclinical data on BG-104, a trispecific GLP-1/GIP/hGH receptor agonist that also targets the Activin Type II receptor pathway.

Basically, think about the multi-receptor concept behind retatrutide, except instead of:

-> GLP-1 + GIP + glucagon

BG-104 is combining:

-> GLP-1 + GIP + direct growth hormone receptor signaling, while also targeting a pathway involved in skeletal muscle regulation.

The goal here seems pretty clear... lose fat while preserving as much muscle as possible.

A bodybuilder's wet dream lol.

Mechanism:

> GLP-1 receptor agonism - appetite suppression, satiety and glucose regulation
> GIP receptor agonism - additional incretin signaling and metabolic effects
> hGH receptor agonism - direct growth hormone receptor signaling rather than simply stimulating endogenous GH release
> Activin Type II receptor targeting - adds another pathway involved in regulating skeletal muscle mass

One of the BG-104 researchers, Young Chul Sung, previously worked extensively on GX-H9, a long-acting recombinant human growth hormone.

GX-H9 used actual recombinant hGH fused to a hybrid Fc domain made from IgD + IgG4, allowing direct growth hormone receptor activation while dramatically extending its half-life.

That does NOT mean BG-104 uses the exact same architecture.

But it doesn't rule it out either, because the full molecular structure of BG-104 has not been publicly disclosed yet.

Given Sung's previous work, the "hGH receptor agonist" part of the equation becomes a lot more interesting.

This could be closer to a multifunctional fusion biologic carrying direct GH receptor activity than a simple peptide designed to make your pituitary release more GH.

That makes it a VERY different beast of a compound compared to something like retatrutide.

Findings so far:

> Tested in aged, diet-induced obese mice
> BG-104 was dosed every 4 days and compared against tirzepatide
> Total weight loss was comparable to tirzepatide
BG-104 showed superior preservation of lean mass
> ~99.5% of the total weight lost was attributed to FAT MASS

Obviously this is still preclinical mouse data.

But if BG-104 can reproduce anything remotely close to this in humans, that would be a VERY different value proposition than simply making another stronger GLP-1.

Source: Jeon et al., Diabetes, 2026. Abstract 3075-LB.

[GLP-1 LIFE! @GLP1_LIFE]

@AvePeptidePixie @RetaUnfiltered

[Democratus @DemocratusMagna]

Retatrutide has a 6 Day half life.

That means that each dose of Reta takes up to 24 Days to clear your body

That's why there is a titration schedule and why that schedule says hold a dose for 3-4 weeks MINIMUM before going up in dose.

I did the math in an earlier, longer post today. Here's the short version.

You inject a 1.0mg dose on Monday. By Sunday you still have roughly 0.5mg active in your system.

After 12 days you still have roughly 0.25mg active in your system.

And at 18 days, you would still have roughly 0.125mg of that original injection, active in your system.

That's on top of the remainder of your 1.0mg injection at day 8, AND the remainder of your 1.0mg injection at day 15.

A 1.0mg weekly injection schedule means that you have MORE than 1.0mg active in your system.

By that 3rd weekly dose of 1.0mg at Day 22, you should have just over 1.6mg active in your body.

And that's for dosing 1X week.

The math gets more interesting if you're breaking that dose up into 2X, or more, per week.

It takes almost 4 weeks for that original dose to clear your system. And every dose after that first one, is still active to some degree.

You need to hold that dose amount for close to 4 weeks to truly know how your body responds to that dose amount.

[GLP-1 LIFE! @GLP1_LIFE]

#retatrutide
https://t.co/1jMXcLb7Kt

[GLP-1 LIFE! @GLP1_LIFE]

@arvindmahajan @WSJ Lowering their prices would resonate more.

[GLP-1 LIFE! @GLP1_LIFE]

$NVO #Novo #Wegovy
https://t.co/GbjkvF6mJ9

[GLP-1 LIFE! @GLP1_LIFE]

#Ascendis regains obesity rights as $NVO exits monthly #GLP1 deal
https://t.co/betjTzHiEz

[On The Pen™ @ManOnThePen]

https://t.co/iGYLcrxWBS

[GLP-1 LIFE! @GLP1_LIFE]

When to increase or decrease you #glp1 dose. #zepbound #Mounjaro #ozempic #wegovy
https://t.co/PItWTKIRFh

[GLP-1 LIFE! @GLP1_LIFE]

#EliLilly @EliLillyandCo to present new data on #Foundayo, #retatrutide, and #eloraTZP at EASD 2026, as it strives to change the course of cardiometabolic health $LLY
https://t.co/567D6EA7pr

[GLP-1 LIFE! @GLP1_LIFE]

@EliLillyandCo #EliLilly $LLY #Psychedelic #Psychedelic
https://t.co/IdgJcg4D4D

[GLP-1 LIFE! @GLP1_LIFE]

#EliLilly $LLY #zepbound #tirzepatide #Mounjaro
https://t.co/C2lNp4F4nh

[GLP-1 LIFE! @GLP1_LIFE]

#Peptides #retatrutide #tirzepatide

https://t.co/SA9EIff5QO