ingenious targeting laboratory

Let’s explore new scientific possibilities together! At Ingenious, we’re passionate about advancing research through custom targeted mouse models.

[ingenious targeting laboratory @GeneTargeting]

ingenious is more than just a solution for custom mouse models. Swipe through to see our 4 pillars of service!

We do...
🐭 Custom Mouse Models
🐁 Catalog Mouse Models
🔬 Cohort Breeding
🧪 Preclinical Services

#custommice #mousemodels #genetargeting #geneediting

[ingenious targeting laboratory @GeneTargeting]

Linked loci, maternal Cre activity, and germline recombination can derail a conditional cross. Let ingenious review the scheme and genotyping before pairs are set.
#ConditionalKnockout #CreLox #MouseBreeding

[ingenious targeting laboratory @GeneTargeting]

Explore knockout, conditional knockout, knockin, reporter, Cre driver, transgenic, humanized, and disease-model lines, with breeding and cohort support when needed.
#MouseModels #MouseModelGeneration #PreclinicalResearch

[ingenious targeting laboratory @GeneTargeting]

Looking for a mouse model for your study? ingenious’s catalog includes 14,774 models across 5,000+ unique genes. Ask about availability and ship dates before planning your study start.
#MouseModels #ResearchTools #LabLife

[ingenious targeting laboratory @GeneTargeting]

Let ingenious handle the cross and colony work. We check linkage, calculate pair count, genotype the pups, and deliver experimental mice with littermate controls.
#ConditionalKnockout #MouseBreeding #MouseCohortDevelopment

[ingenious targeting laboratory @GeneTargeting]

When mice arrive weeks apart, age can complicate the comparison. ingenious manages parallel breeding and release timing around the age range your protocol requires.
#MouseCohortDevelopment #MouseBreeding #PreclinicalResearch

[ingenious targeting laboratory @GeneTargeting]

Target genotype, sex, age range, and littermate controls can shrink the usable cohort fast. ingenious calculates pair count and expected yield before breeding begins.
#MouseCohortDevelopment #MouseBreeding #ConditionalKnockout

[ingenious targeting laboratory @GeneTargeting]

Our guarantee is simple. We deliver a mouse with confirmed germline transmission of your specified modification, or you are not charged. 2,800+ custom models since 1998, U.S.-based QC at every stage. Quote in 24 hours.
#MouseModels #GeneTargeting #Preclinical

[ingenious targeting laboratory @GeneTargeting]

Published in Cell Reports in 2026: Nagai et al. reported on mast cell-specific CysLT2 receptor signaling and cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation using Cysltr2 floxed mice generated by ingenious targeting laboratory.

[ingenious targeting laboratory @GeneTargeting]

Founder mice do not establish a line. The allele must transmit through the germline before breeding and cohort planning can begin. ingenious guarantees transmission. If it does not transmit, you are not charged.
#MouseModelGeneration #GermlineTransmission #GeneTargeting

[ingenious targeting laboratory @GeneTargeting]

New in J Exp Med: Wetterwald et al. link a MYCT1 and IFITM2/3 interaction to endothelial endolysosomal trafficking and white adipose expansion. iTL provided the mouse model. Findings are the authors'. Paper below.
#Metabolism #VascularBiology #Adipose

[ingenious targeting laboratory @GeneTargeting]

If the floxed locus and the Cre insertion sit on the same chromosome, Mendelian ratios do not apply. You need a meiotic recombination event, and yields fall off a cliff. Check locus positions during design, not after weaning. #CreLox #MouseGenetics #ConditionalKnockout

[ingenious targeting laboratory @GeneTargeting]

Pups arriving across eight weeks is not a cohort. It is an uncontrolled age variable sitting inside your study group. Parallel pairs with staggered starts land the litters in one window. Ask us to size the scheme. #MouseModels #PreclinicalResearch #InVivo

[ingenious targeting laboratory @GeneTargeting]

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[ingenious targeting laboratory @GeneTargeting]

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[ingenious targeting laboratory @GeneTargeting]

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[ingenious targeting laboratory @GeneTargeting]

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[ingenious targeting laboratory @GeneTargeting]

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