Genera

Genera è una rete di cliniche specializzate in procreazione medicalmente assistita.

[Genera @Genera_pma]

@drbarisata @juanjo_fraire @GLiperis @LaurCraciunas @SCobanMune @MicahJHillDO @PaolaVigano3 #eshrejc
Agree 100% we shall start talking about family planning and not a single child. Even because the replacement rate is 2.1 babies per couple.

[Genera @Genera_pma]

@GLiperis @LaurCraciunas @SCobanMune @MicahJHillDO @drbarisata @PaolaVigano3 #eshrejc
Well cost-effectiveness and risk analysis are required here in my view. Provided that the patients does not dropout and is willing to go another stimulation (psychologically, physically and economically), you can try another cycle. In Italy we have no choice due to Law40

[Genera @Genera_pma]

@juanjo_fraire @LaurCraciunas @ESHRE @PirteaP @NMacklon @drbarisata @maclaudiaa @PaolaVigano3 @MicahJHillDO @JuanchoGVelasco #eshrejc
Love this paper and the concept of the endometrium being a biosensor on reproductive incompetence. We discussed this (as many other authors did) in our studies on the miRNAs released in the culture media during IVF

https://t.co/GEXSRLLVmR

[Genera @Genera_pma]

@drbarisata @GLiperis @juanjo_fraire @LaurCraciunas @ESHRE @PirteaP @PaolaVigano3 @MicahJHillDO @kashish__ @SCobanMune @NMacklon @JuanchoGVelasco #eshrejc
That is indeed the point that also with eshre we tried to make, coming up with a statistically-based definition. Not too far from what the Lugano consensus did.
RIF might just be an epiphenomenon of IVF in most cases

https://t.co/wBFKOHfkef

https://t.co/pXgLMKdsDz

[Genera @Genera_pma]

@GLiperis @PaolaVigano3 @PirteaP @LaurCraciunas @MicahJHillDO @juanjo_fraire @SCobanMune @kashish__ #eshrejc
they cannot at least across different clinics. Still that is a factor to be considered and that should be acknowledged to the patients. Plus chromosomal aneuplodies are not everything that matters, there Is also ploidy issues or segmentals just to mention other issues

[Genera @Genera_pma]

@SCobanMune @GLiperis @juanjo_fraire @ESHRE @PirteaP @PaolaVigano3 @LaurCraciunas @MicahJHillDO @drbarisata @kashish__ @NMacklon #ESHRE jc
We tend to discourage it
Especially in view of GILL’s data the chance is not lower if they failed previously
Perhaps a different discussion might be done in case of embryos lower than BB or day7 euploid, but still I see the risks of multiple pregnancy much worse

[Genera @Genera_pma]

@juanjo_fraire @LaurCraciunas @ESHRE @PirteaP @PaolaVigano3 @MicahJHillDO @drbarisata @GLiperis @kashish__ @SCobanMune @NMacklon @JuanchoGVelasco #ESHREjc
Well, with euploid blastocysts I will highly discourage a double ET

[Genera @Genera_pma]

@juanjo_fraire @PirteaP @LaurCraciunas @MicahJHillDO @PaolaVigano3 @JuanchoGVelasco @drbarisata #ESHREjc
It should not on a small scale
Perhaps on a large scale

[Genera @Genera_pma]

@juanjo_fraire #ESHREjc
We tried to discuss this topic in the past
To define ivf as journey and not a single attempt
Gills paper well fits into this context

https://t.co/oNM6zXXbjS

[Genera @Genera_pma]

@ESHRE @OUPMedicine @GLiperis @SCobanMune @kashish__ @juanjo_fraire @drbarisata @JuanchoGVelasco @fubaldi

[Efi @eficonstantinou]

A very interesting program that covers from preconception to postnatal period.

Looking forward to this 👌

[Genera @Genera_pma]

@IreneCuevasSaiz @GLiperis #eshrejc we asked them to be honest, but clearly this cannot be absolutely kept under control. The good thing is that I knew the true outcome of those embryos, and the discard rate was rather low among euploid blast and LBs. Maybe, embryologists can distinguish low from too low

[Genera @Genera_pma]

@OmarRawi89 @juliauraji #eshrejc not to my knowledge, but simply because the decisional support is currently based on prioritisation (i.e., transfer first or later) and not opportunity of clinical use (i.e., quality too low in this given couple for clinical use). Still, an interesting use case I think

[Genera @Genera_pma]

@SofiaMakieva #eshrejc @DeanMorbeck published a wonderful paper on the clinical value of C-grade blastocysts

https://t.co/Gm7JiaQuyi

[Genera @Genera_pma]

@IreneCuevasSaiz @SCobanMune @alteri_ale @SofiaMakieva @juanjo_fraire @PisaturoValerio #eshrejc correct. Indeed they require a case by case patient centered decision. Therefore, standardisation is even more important

[Genera @Genera_pma]

@catello_scarica @GLiperis @IreneCuevasSaiz @juanjo_fraire @PisaturoValerio @SCobanMune @ESHRE #eshrejc correct. This is the most likely explanation

[Genera @Genera_pma]

@juliauraji @juanjo_fraire @IreneCuevasSaiz #eshrejc yes correct. Yet it corresponded for all the embryologists

[Genera @Genera_pma]

@eficonstantinou #eshrejc absolutely. No doubt about that: we make decisions every day based on subjective assessments. One of the main advantages of AI will be standardisation even more than prediction

[Genera @Genera_pma]

@SCobanMune @alteri_ale @SofiaMakieva @juanjo_fraire @PisaturoValerio #eshrejc these embryos are more aneuploid and less competent, but apparently they are not more subject to an impact of the biopsy (I.e., pre-vitrification or post-warming degeneration) nor to higher risks of no result.