Genomics Cow

Original and probably disagreeable perspectives on genomics. Not sure when I'm joking and when I'm being serious. Opinions my own, not the herd’s.

[Genomics Cow @GenomicsCow]

#Genomics on social media is mainstream. Kinda boring.
Don't follow the herd

[Genomics Cow @GenomicsCow]

@MariosGeorgakis Great summary. Worth the time to read

[Genomics Cow @GenomicsCow]

This is foreboding for Alamar. Their stance on sensitivity only matters if they can demonstrate others cannot keep up AND this matters. What can they prove outside of neuro that Quanterix couldn’t?

🐄

[Genomics Cow @GenomicsCow]

Alamar growing FAST 📈📈📈

But I think they risk being capped like Quanterix

https://t.co/HgqS35uVj7

[Genomics Cow @GenomicsCow]

But this is just 1️⃣ niche and their growth prospects rely on this playbook working in other fields

Quanterix tried the field-wide sensitivity play, yes with limited plex, but had to narrow down into the neuro niche because that’s where it fit

[Genomics Cow @GenomicsCow]

@OmicsOmicsBlog Maybe the board listened to complaints about likeability 🤷‍♀️

[Genomics Cow @GenomicsCow]

This 👇👇👇

[claire vo 🖤 @clairevo]

X sucks the least for me.
TikTok is actually pretty great as a female creator.
YouTube is all my content so audience is nice
LinkedIn is 90% AI trash
Facebook is hell
Reddit is hell but thanks for the training data
Threads I should probably not ignore
Bluesky kill me I would build a data center just for the pure joy of triggering ppl there

[Genomics Cow @GenomicsCow]

AGBT27 calls for sponsors this week!🚨

Remember that sponsoring
- Shows how healthy you’re feeling
- Is like the preprint equivalent of product launches
- Isn’t about your science but connections to influencers, press, and industry analysts

[Genomics Cow @GenomicsCow]

@MariosGeorgakis Even then, this is hard. Not unlike DTC tests explained below, PRS’ are faced with a “add-more-cost or risk-leaving-patients-out” proposal

[Genomics Cow @GenomicsCow]

Your test could save money by reducing usage of standard clinical pathways (eg remove low risk ppl from routine screening), but not many doctors (or patient who was eager enough to buy a DTC test) would really take this "less testing" route based on a fringe test

[Genomics Cow @GenomicsCow]

@MariosGeorgakis You make good points

PRS advocates have to remember
- Don’t boil the ocean
- Start where there is a scaffold for uptake: where there are already screening pathways like you indicated

[Genomics Cow @GenomicsCow]

@ealarkin7 Oftentimes reporting all sorts of things creates the diagnostic odyssey

But i get that your target patient/physician population is different

[Genomics Cow @GenomicsCow]

Clinician:
I don’t read papers. Is it in clinical guidelines?

PI:
what peer-reviewed journal is it in? I only read preprints if I’m an author

Vendor marketing:
Here’s our white paper. But if you want a deep dive on validation here’s the biorxiv link

🐮

[Genomics Cow @GenomicsCow]

If companies ever develop a successful medical DTC that isn’t part of standard testing

They’ll get shut down or shunned anyway

Leave the naive work to the tech bros impatient to get things done

[Genomics Cow @GenomicsCow]

Life science tool shows diagnostic potential!
So let's do a direct-to-consumer medical test!

You can't seriously do DTC until . . . 🧵

1/2 Your product could actually exist as a clinical test. You cannot expect to skip years of validation and expect a business to take off

[Genomics Cow @GenomicsCow]

@OmicsOmicsBlog "I just want stuff moved, spare me the details" 😂

I wonder why Tecan and Hamilton couldn't be more similar though, given their proximity and higher likelihood their staff have higher chances of working in both

[Genomics Cow @GenomicsCow]

If you want to do DTC ...

Get someone else to take on the risk
Look for tech bro's, ppl with access to funding to waste, they talk with language like "digital twin" and "AI". If they succeed, sell them the tools. If they don't, make sure they pay their outstanding invoices!

🐄

[Genomics Cow @GenomicsCow]

Life science tool shows diagnostic potential!
So let's do a direct-to-consumer medical test!

You can't seriously do DTC until . . . 🧵

1/2 Your product could actually exist as a clinical test. You cannot expect to skip years of validation and expect a business to take off

[Genomics Cow @GenomicsCow]

Your test could cost more money by screening ppl earlier (to save 💰 later), but this isn't an easy argument to attain reimbursement for