Georgette Tanner

Bioinformatician at Oxford Nanopore Technologies

[Glioma Genomics Research Group @GliomaGenomics]

We are thrilled to have published our recent findings regarding the way that GBM tumours adapt to, and survive, treatment in @GenomeBiology. This brief thread highlights what we found: 1/8

[Glioma Genomics Research Group @GliomaGenomics]

We took cytoplasm from a GBM cell to get its transcriptional profile WITHOUT KILLING THE CELL so we could do the same again, for the same cell, at a later time point. 🤯This blows my mind & is so needed to research glioma cell plasticity! @BrainTumourOrg @UKRI_News @SENTINEL_ITN

[Chalmers @nano_chalmers]

Imagine tracking the same cell's transcriptomic state 3 days later after some chemo and radiotherapy to understand what therapies do to the cell state. Read below for how we use nanotechnology to do this. @paoloactis @LucyFStead
https://t.co/OxxiCUcWP5

[Fabio Marcuccio @Fabio_Marcuccio]

🧬 Gene expression = dynamic! 💥 scRNA-seq = static. 🚀 We developed nanobiopsy to sample glioblastoma cells before/after therapy and track cellular states! 📈 Check out our preprint to see how we added temporal dimension to single-cell transcriptomics!

[Fabio Marcuccio @Fabio_Marcuccio]

🔬 Exciting collaboration with @chalmerscccc, @paoloactis, @LucyFStead, @GeorgetTanner @EI_single_cell! ⏰ After years of work, we pioneered an SICM-based nanobiopsy platform 🧪✨ Sampling cytoplasm at multiple time points 🕓🔬 Revealing cellular plasticity in glioblastoma! 🧠💥

[Paolo Actis @paoloactis]

Superb effort lead by @LucyFStead @Fabio_Marcuccio @chalmerscccc @GeorgetTanner @EI_single_cell and many more enabled by @BrainTumourOrg @UKRI_News @MSCActions

[Glioma Genomics Research Group @GliomaGenomics]

We think we've found something v.interesting 🧐:IDHwt GBMs can be stratified by treatment response which might inform targeted therapies. Read our study here: https://t.co/VHp0numYEV Funded by @UKRI_News @BRUKresearch @DiMeN_Diversity @LDShospcharity @OscarsCharity @YorkshireBTC

[Georgette Tanner @GeorgetTanner]

Thanks Lucy!

[Glioma Genomics Research Group @GliomaGenomics]

Huge congratulations to @GeorgetTanner who aced her PhD viva today! The Glioma Genomics group could not have been blessed with a better first PhD student. We look forward to seeing you soon to celebrate Dr Tanner.

[Glioma Genomics Research Group @GliomaGenomics]

We are a @LIMRLeeds group dedicated to understanding why the most common and most deadly form of brain cancer, glioblastoma, resists treatment. We are computational, we are experimental and we are now on twitter! @LeedsMedHealth

[Georgette Tanner @GeorgetTanner]

@YWHelp The waters gone again, any update on when it'll be fixed?

[Lucy Stead @LucyFStead]

My group's so chuffed to be part of #GLASS, a global effort to longitudinally profile gliomas. 1st paper, lead by @roelverhaak, just published https://t.co/HfsJMBnEsH. Our bit, data analysis by @GeorgetTanner, was funded by @Leeds_Cares @LeedsMedHealth @LeedsHospitals. I ❤ data.

[Lucy Stead @LucyFStead]

Our 1st preprint is online! "JARID2 facilitates transcriptional reprogramming in GBM in response to standard treatment" https://t.co/KZpxqWaKG4 Pls read & RT. Thx @Leeds_Cares @BTRSacrossYorks @yorkshirecancer @LeedsMedHealth & Ellie's Fund 4 funding! @leedsomics @LIDA_UK

[Georgette Tanner @GeorgetTanner]

Just got back from a great few weeks in the US visiting @roelverhaak's group at the Jackson Laboratory and attending the CSHL Biology of Genomes conference. Thank you to Roel and his group for making me feel welcome and also the @EACRnews and @TheBACR for funding the trip.

[Lucy Stead @LucyFStead]

Strange to see a picture I drew with my 4-year old's colouring
pens end up in a @Cancer_Cell preview https://t.co/gP8gzy82OQ! Thanks @roelverhaak for letting me help summarise work showing how longitudinal GBMs can inform on disease progression: https://t.co/T8fdbKVN6O

[Georgette Tanner @GeorgetTanner]

Scientists rise up against statistical significance https://t.co/K9aEGUN2Ye

[Clive McKimmie (VHIT) 🦟🦠🐁 @VHIT_Mckimmie]

Our first ever paper on BioRxiv, shows how therapeutic targeting of skin macrophages at the mosquito bite, using a simple cream, can prevent infection with multiple distinct arboviruses (Alpha,Flavi, Bunyas). Welcome all thoughts and queries! https://t.co/71le9a6Lek

[Roel Verhaak @roelverhaak]

Roses are red
Violins are blue
Share your data
For its the right thing to do
#ScienceValentines #AcademicValentine

[Georgette Tanner @GeorgetTanner]

@LucyFStead @ProfValS I am now!

[Lucy Stead @LucyFStead]

Evolving realistic tumours, and sequencing their DNA, inside computers to help us understand exactly how we should be analysing data from the real thing! Check out our latest publication https://t.co/7n2EyvKcyN