Moheb Ghobrial

[Moheb Ghobrial @GhobrialMoheb]

I am very happy to share that my first-author paper from the PhD work is now published in Nature: https://t.co/37OGWKcVpm

[Johanna Joyce Lab @Joycelab]

We're delighted to welcome our newest postdoc, Dr Moheb Gohbrial 🤩

Moheb joins us from ETH Zurich, after his wonderful PhD with @debocklab, Thomas Walchli & collaborators - generating a powerful brain vascular atlas across development, adulthood and disease 🧠

@GhobrialMoheb

[Stem Cell Podcast @stemcellpodcast]

Drs. @ThomasWalchli, Moheb Ghobrial (@GhobrialMoheb), @GaryBader, Ivan Radovanovic, and others at the @KBI_UHN generated a #SingleCell atlas of the human brain vasculature! 🗺️🧠

@Nature paper: https://t.co/5RqOHPOcDi
Discussion: https://t.co/pHbyuTsxXH

[Endothelial Cell News @endothelialnews]

🔎 Drs. @ThomasWalchli and @GhobrialMoheb at @KBI_UHN performed single-cell RNA sequencing analysis of #endothelial and other tissue-derived cells from 68 patients to construct a molecular atlas of the control and diseased 🧠 brain vasculature.

@Nature | https://t.co/SyOexhvbKE

[Moheb Ghobrial @GhobrialMoheb]

@danis1337 Thanks alot Dan

[nature @Nature]

Nature research paper: Single-cell atlas of the human brain vasculature across development, adulthood and disease https://t.co/b85nW0opai

[Moheb Ghobrial @GhobrialMoheb]

@danis1337 so it is not just "tumor" 😉

[Moheb Ghobrial @GhobrialMoheb]

@danis1337 our sc-atlas describes the transcriptional heterogeneity of endothelial and perivascular cells across the developing, adult homeostatic, and pathological brain vasculature - including brain tumors (LGG, GBM, metastasis, meningioma) and brain vascular malformations (AVMs).

[Moheb Ghobrial @GhobrialMoheb]

I am grateful to a great team of scientists that made this work possible
Especially my PhD mentors @debocklab,@garybader1 , Ivan Radovanovic, and @ThomasWalchli with whom I extensively discussed🙏
“No one can whistle a symphony. It takes an orchestra to play it.”

[Moheb Ghobrial @GhobrialMoheb]

I am very happy to share that my first-author paper from the PhD work is now published in Nature: https://t.co/37OGWKcVpm

[Moheb Ghobrial @GhobrialMoheb]

- iii) they also play a key role in the human brain neurovascular unit a across development, adulthood and disease.

[Thomas Wälchli @ThomasWalchli]

I'm very excited to share our paper "Single-cell atlas of the human brain vasculature across development, adulthood and disease"
- https://t.co/oX39Y8sDXU
published in Nature!
Further reading:
- https://t.co/gaQ7GVMgvg (Nat Rev Neurosci)
- https://t.co/BPfW7vQeNS (JCI Insight)

[Moheb Ghobrial @GhobrialMoheb]

@garybader1 @ThomasWalchli Thanks alot @garybader1 for your support and guidance

[Krembil Brain Institute @KBI_UHN]

An international consortium of researchers led by @UHN @KBI_UHN & @UZH_en build first-ever molecular atlas of the human brain’s vasculature, across early brain development, adulthood & disease.

Read more in @Nature -> https://t.co/BLiMfl7WVI

[Gary Bader @garybader1]

Congratulations @ThomasWalchli @GhobrialMoheb Marc Schwab, Ivan Radovanovic and many others who contributed to this massive effort to map the human brain vasculature across development, adulthood and disease! It has been a pleasure to be part of the team.

[Moheb Ghobrial @GhobrialMoheb]

Endothelial cells from vascular-dependent central nervous system (CNS) diseases
i) reveal reactivated fetal pathways

[Moheb Ghobrial @GhobrialMoheb]

@Johanna_A_Joyce @AACR Congratulations 👏👏