Jason Gleghorn

Engineering, medicine, and biology group @UDelaware. mechanics of morphogenesis | lung & placental development | maternal-fetal health | regenerative medicine

[Jason Gleghorn @GleghornLab]

Excited to enter into the AI and machine learning arena! Check out our preprint, led by @Logan_Hallee, showcasing a robust protein-protein interaction (PPI) predictor powered by a large language model. We call it SYNTERACT. https://t.co/Qogo0O9JVT

A thread (1/5)

[Jason Gleghorn @GleghornLab]

We’re excited to share our latest paper! BEADS is a semi-automated workflow for 3D endothelial angiogenesis analysis, designed to streamline image analysis while keeping researchers in control through interactive correction.

https://t.co/9geESG0BVz

[Jason Gleghorn @GleghornLab]

Cells don’t experience mechanical cues one at a time, so neither should our models. Our new, easy-to-use flow chamber reveals synergistic effects of ECM stiffness and shear stress on epithelial cytoskeletal organization.
https://t.co/AWH67u9vsB

[Jason Gleghorn @GleghornLab]

Check out our newest preprint where we walk through a workflow for harvesting, sectioning, and staining murine lymph nodes for high-fidelity 3D reconstruction!
https://t.co/r2915mwJLA

[Jason Gleghorn @GleghornLab]

Thrilled to share our new paper in Advanced Healthcare Materials!
We developed a modular, reusable, perfusion-ready OOC system that lowers the barrier to entry for microphysiological studies. Excited to see this accessible design enable cool science!
🔗 https://t.co/Wvmpit4hic

[Science Advancement and Outreach @SAOscience]

Congratulations to the @GleghornLab on this excellent feature! 🎉

Instead of experimenting on animals, Jason Gleghorn's group is using microfluidic systems. Because the platform doesn’t require specialized equipment and is compatible with tools already available in standard biology labs, research teams across four continents are using these chips to study women's health and more.

In Gleghorn's @UDelaware boot camps, researchers will learn how to use these devices and can take the technology back to their own labs.

@UDResearch

Article by @krobUD in @UDaily:

https://t.co/Ux0ChKFvwc

[Jason Gleghorn @GleghornLab]

A modular microphysiological platform for studying the cervicovaginal epithelium!
We introduce an accessible, PDMS-free organ-on-chip system validated with microbiota, Chlamydia, Gonorrhea, and neutrophils.
📄
#microphysiology #WomensHealth #Organoids #InfectiousDisease

[biorxiv_bioengineering @biorxiv_bioeng]

A Microphysiologic Model of the Cervical Epithelium Recapitulates Microbial, Immunologic, and Pathogenic Properties of Sexually ... https://t.co/STmRzmV58t #biorxiv_bioeng

[Jason Gleghorn @GleghornLab]

Introducing our latest in @JControlledRel:
We chart a translational roadmap to advance therapeutic nanoparticle safety in pregnancy—leveraging environmental nanotoxicology to study placental and fetal exposure.
#Nanomedicine #MFH #Nanotoxicology

[J Controlled Release @JCRnEDITORS]

Therapeutic nanoparticle safety in pregnancy: Bridging knowledge gaps with environmental insights and a translational roadmap.
| Jason P. Gleghorn @UDelaware |
[50 days' free access]
#nanoparticle #safety #pregnancy
https://t.co/wHVtReubqo

[Jason Gleghorn @GleghornLab]

Check out our latest article published in @AJPLung on how the nitrofen/bisdiamine murine model of CDH has a pulmonary hypertension vascular phenotype consistent with human CDH! Excited to share this work by @crgonyea @udbme

[AJP-Lung Cellular and Molecular Physiology @AJPLung]

By @crgonyea et al. (@GleghornLab @Rach_M_Gilbert @YuanjunS @_KMNelson @OOOLUTOYE) #Nitrofen / #bisdiamine murine model of congenital #diaphragmatichernia has a #pulmonaryhypertension #vascularphenotype consistent with human #CDH
https://t.co/wQvFyWBm4r

[AJP-Lung Cellular and Molecular Physiology @AJPLung]

Let's check out this amazing #ArticleinPress from @udbme! The nitrofen/bisdiamine murine model of congenital diaphragmatic #hernia has a pulmonary #hypertension vascular phenotype consistent with human #CDH (Cailin R. Gonyea et al.):

https://t.co/izGVkohAsV

[bioRxiv @biorxivpreprint]

A straightforward cell culture insert model to incorporate biochemical and biophysical stromal properties into transplacental transport studies https://t.co/Fg8UwL7DyT #bioRxiv

[Jason Gleghorn @GleghornLab]

Congratulations to @MDonzanti on successfully defending his dissertation! 🍾🎉 #lymphnode #drugdelivery

[Jason Gleghorn @GleghornLab]

@AlbertVilella We have model weights on HuggingFace (GleghornLab) and working on full manuscript submission with code details there.

[Jason Gleghorn @GleghornLab]

1/6 New preprint alert!🚨
Advancements in protein language models have implications in fundamental biology studies and therapeutic design. @Logan_Hallee's work explores alternate vocabularies beyond amino acids, such as codons and their extended potential. https://t.co/HKUtPImANw

[Jason Gleghorn @GleghornLab]

6/6 Curious to learn about MELD, our in-depth analysis, and other exciting findings? Checkout our preprint on bioRxiv: https://t.co/HKUtPImANw

[Jason Gleghorn @GleghornLab]

5/6 Our findings have important implications. This work calls for building a codon-based protein foundation model at a large scale for new SOTA function and structure prediction. Additionally, it is crucial to include high-quality coding region data with repositories like UniProt

[Jason Gleghorn @GleghornLab]

Last one of the season! Congratulations Dr. @ABozorgnezhad for successfully defending your thesis 🎉🎓 #CFD

[Jason Gleghorn @GleghornLab]

Congratulations to Dr.@AllyMDang for successfully defending her PhD! 🎓🎉Well done! #drugdelivery