Chris de Graffenried

Cell biologist studying morphogenesis in parasitic eukaryotes. Based at Brown University, Providence, Rhode Island.

[Chris de Graffenried @GraffenriedDe]

People with or without experience working with parasites are encouraged to apply! There is so much cool biology to study in "non-model" organisms...

[Chris de Graffenried @GraffenriedDe]

I just posted new postdoc and technician positions for my lab. Projects include T. brucei live-cell imaging, studying novel microtubule-binding proteins using biophysics and microscopy techniques, and molecular dissection of cell division mechanisms in Trypanosomatids.

[Chris de Graffenried @GraffenriedDe]

Postdoc position:
https://t.co/zwDMxEOwJP

Tech position:
https://t.co/JYAabkesEi

[Chris de Graffenried @GraffenriedDe]

Congratulations to former de Graff lab members Tom (first and co-corresponding author) and Paul Campbell (2nd author) for their fantastic work!

[Chris de Graffenried @GraffenriedDe]

A quick post about our recent paper. We used biophysics to show that the T. brucei kinesin KLIF assembles MTs into parallel bundles, which could explain how it helps to complete cytokinesis by aligning MT plus ends to create a new cell posterior.
https://t.co/FOj9I66cPw

[Chris de Graffenried @GraffenriedDe]

KLIF is an “orphan” kinesin, but appears to have convergently evolved many features present in mitotic kinesins that allow them to organize MT structures such as the spindle. Just another example of how many cool divergent proteins and pathways there are in “non-model” systems!

[Haley Licon @mhlicon]

If you’re a Boston area parasitologist and haven’t heard, BAPS is starting up again! Follow on twitter and keep your eyes peeled for our updates! 👀

[Matt Pratt @MattRPratt]

Fantastic time celebrating with Nobel Prize with @CarolynBertozzi in the Bertozziverse. ~130 past and present members of the lab.

[The Nobel Prize @NobelPrize]

Just in!

First selfie from our 2022 #NobelPrize laureate in chemistry @CarolynBertozzi. Congratulations!

[The Nobel Prize @NobelPrize]

"It's an opportunity for me to recognise that all the work that so many trainees from my lab have done over the past 25 years and to reflect on how fortunate I have been and share in the celebration with them."

– 2022 chemistry laureate @CarolynBertozzi on her #NobelPrize

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

[PLOS Biology @PLOSBiology]

#Apicomplexan #parasites #Babesia are hard to sync, limiting knowledge of their biology. #scRNAseq of 3 species allows mapping of the replication cycle & construction of pseudo-sync'ed time-course gene expression profiles @DuraisinghLab &co #PLOSBiology https://t.co/JAnrDoGZx9

[Boris Striepen @striepenlab]

Next Monday 12 pm ET Alex Peredez Global Parasitology talk on cool Giardia cell biology. ⁦@TrendsParasitol⁩ ⁦@ASTMH⁩ ⁦@PLOSBiology⁩ ⁦@AS_Para⁩ ⁦@BSPparasitology⁩ ⁦@ParaFrap⁩ ⁦@pennvet⁩ ⁦@PennBiology⁩ ⁦@pennbgs⁩

[Boris Striepen @striepenlab]

Rick Tarleton’s decades of effort to develop urgently needed better treatment paid off tremendously. 100% cure in mice and non-human primates! Read their paper in ⁦@NatureMicrobiol⁩! https://t.co/hs2kkKm7kF

[Richard Wheeler @Zephyris]

Incredible resource! But also important to point out that you can get some better predictions in divergent lineages using deeper custom databases for multiple sequence alignment input: https://t.co/0NLwimwOK9

[Keith Matthews @KeithRMatthews]

Congratulations ⁦@Frank_Venter⁩ ⁦@Mabel_Tettey⁩ and Tadhg Devlin on you PhD graduation ⁦@EdinburghUni⁩ What a lab team for the last few years !

[Chris de Graffenried @GraffenriedDe]

As of today, I am now an Associate Professor at Brown University! It’s been quite a ride, especially over the last 2 years. With a great new crop of lab members and job security, things are really looking up. I want to thank all my friends and colleagues for their support!

[Álvaro AcostaSerrano @AAcostaserrano]

Another great feat by this year’s @MBLBoP students by setting up expansion microscopy protocol #UExM using mutant #trypanosomes Well done guys!! @MBLScience @BBurleighChagas @FrischknechtLab @aitorcasass @GraffenriedDe @ZEB_UniWue

[Biological Sciences | University of Edinburgh @SBSatEd]

Congratulations @KeithRMatthews a fantastic achievement!👨‍🔬🌟

[BiologyofParasitism @MBLBoP]

Welcome BoP 2022