HIRO-NOG

Human trials are underway for a drug that regrows human teeth in just 4 days. Scientists are initiating human trials for a groundbreaking drug designed to regrow teeth naturally, potentially rendering dentures and implants obsolete. For decades, permanent tooth loss has been considered an irreversible part of aging or injury, leaving millions reliant on synthetic implants and dentures. However, researchers at Kyoto University are now challenging this biological limitation by launching human trials for a drug that triggers natural tooth regrowth. The treatment works by inhibiting a protein called USAG-1, which normally suppresses the maturation of "extra" tooth buds. By blocking this biological brake, scientists have successfully grown new, fully functional teeth in animal models, effectively tapping into a latent "third dentition" that humans carry in a suppressed state. The project is being advanced by the startup Toregem BioPharma, with an initial clinical focus on individuals with congenital tooth agenesis—a condition where adult teeth never form. These patients are ideal candidates because their dormant tooth buds are already present but inactive, waiting for the correct biological signal to mature. While the drug requires precise timing and developmental context to work effectively, its success could signal a massive paradigm shift in restorative medicine. Moving beyond porcelain and titanium, the future of dentistry may lie in the body’s own inherent ability to regenerate its natural anatomy. source: Takahashi, K., Kiso, H., & Murashima-Suginami, A. Advances in tooth agenesis and tooth regeneration. Regenerative Therapy

ShiningScience's tweet photo. Human trials are underway for a drug that regrows human teeth in just 4 days.

Scientists are initiating human trials for a groundbreaking drug designed to regrow teeth naturally, potentially rendering dentures and implants obsolete.

For decades, permanent tooth loss has been considered an irreversible part of aging or injury, leaving millions reliant on synthetic implants and dentures. However, researchers at Kyoto University are now challenging this biological limitation by launching human trials for a drug that triggers natural tooth regrowth. The treatment works by inhibiting a protein called USAG-1, which normally suppresses the maturation of "extra" tooth buds. By blocking this biological brake, scientists have successfully grown new, fully functional teeth in animal models, effectively tapping into a latent "third dentition" that humans carry in a suppressed state.

The project is being advanced by the startup Toregem BioPharma, with an initial clinical focus on individuals with congenital tooth agenesis—a condition where adult teeth never form. These patients are ideal candidates because their dormant tooth buds are already present but inactive, waiting for the correct biological signal to mature. While the drug requires precise timing and developmental context to work effectively, its success could signal a massive paradigm shift in restorative medicine. Moving beyond porcelain and titanium, the future of dentistry may lie in the body’s own inherent ability to regenerate its natural anatomy.

source: Takahashi, K., Kiso, H., & Murashima-Suginami, A. Advances in tooth agenesis and tooth regeneration. Regenerative Therapy

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HIRO-NOG @HIRONOG347828

7 days ago

【小沢一郎が野党に喝？！】自民党に代わる選択肢はないのか／野党は政権を取る気迫を出せ！／高市政権が目指す対米・対中外交は危うい？／皇室典範改正を... https://t.co/YYRLJaG9N2 @YouTubeより

HIRO-NOG @HIRONOG347828

8 days ago

＃熊本ラーメン店開けるほど美味しいラーメンについて https://t.co/vcc5VmP0GY @YouTubeより

HIRO-NOG @HIRONOG347828

10 days ago

@askaakiox 米軍の所有物となり不可能になると同じで、JAL機に日本の政府自衛隊警察による隠蔽工作ができなくなるからと個人的に推測しています。

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HIRO-NOG @HIRONOG347828

10 days ago

@askaakiox 今の季節が来ると話題になる日航JAL123便の事故。横田基地に不時着させないためにファントム機で追尾・攻撃したのは、横田基地に着陸されると、以前あった沖縄の校舎にヘリが墜落した事故のように、日本の公権力による現場検証が安保条約により校舎までも一時的にせよ

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HIRO-NOG @HIRONOG347828

10 days ago

【小沢一郎×白井聡】小沢一郎が語る「日本改造計画」 / 9条を守っても変えても平和は来ない / 本人が明かす「第七艦隊発言」2009年の真意 /... https://t.co/zF6xH1QFD1 @YouTubeより

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@GobonotoJP

about 1 year ago

誰このジャーナリスト気取りの馬鹿上杉隆(うえすぎたかし) 「S級のネタです」とか言って名前も顔も出させて現場に居合わせた医学生を出演させて肝心な事は何一つ聞かない大丈夫か？こいつこーゆージャーナリスト気取りのフニャフニャな連中が今の斬り込めないジャーナリズムの土台を築いた情けない問題になってるのは射入口と射出口だよ尖ったピストルの弾が体に入る射入孔(しゃにゅうこう)は一般的に小さいところが秒速600m〜1000m(ジェット機よりも速いマッハ2)で弾が体に当たる衝撃で弾は潰れて変形する潰れて変形した弾が体の外に排出される射出孔(しゃしゅつこう)は肉片が飛び散る程に大きくなる安倍晋三さんを蘇生させようと懸命に尽力された救命センター長の福島英賢(ひでただ)先生の見解と後から記者会見した奈良県警の公表との食い違い点はこの射入孔と射出孔のズレ見解は真逆わざわざ現場に居合わせた医学生に会いに行って肝心の射入孔と射出孔の話をせずに帰ってきたアホジャーナリスト上杉隆「S級のネタです」てこれのどこがS級なんだよクソしらけるこいつ山上は単独犯ですて笑大丈夫か？こいつ？！こーゆーどーしよーもない奴がジャーナリズムを腐らせてきた安倍晋三さんは、そもそもタレント候補の松山三四六(まつやまさんしろう)の応援で長野県に入る予定だったところが7月6日に文春が松山三四六の女性スキャンダルを記事にして急きょ7月7日に予定変更になり８日に奈良県入りしたしかも奈良県では10日前にも演説を行っている文春が7月6日にスキャンダルを記事にしなければ安倍晋三さんの7月8日の奈良入りは無かった文藝春秋マターで7月6日の記事を書かせた人物から犯人に繋がるのであり山上が単独で出来る芸当ではないこのフニャフニャの嘘ジャーナリスト達が日本のジャーナリズムを地に落としましたこれからも嘘と戦っていきます奥野卓志

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