SGLT2 inhibitors work fast in heart failure
🔵 DAPA-HF (HFrEF): Day 28
🔵 EMPEROR-Reduced (HFrEF): Day 12
🟢 EMPEROR-Preserved (HFmrEF/HFpEF): Day 18
🟢 DELIVER (HFmrEF/HFpEF): Day 13
🟢 EMPULSE (Acute HF): Day 15
🔴 SOLOIST-WHF (Worsening HF): ≤30 days
Empezar hemodiálisis 3 veces/semana siempre es necesario? Un metaanálisis de 138 mil pacientes sugiere que iniciar de forma incremental (2 sesiones/semana en pacientes seleccionados) preserva mejor función renal residual, reduce hospitalizaciones y podría bajar mortalidad.
⭕️1 gramo calcio gluconato=9.3 de calcio elemental
⭕️5.4-21.5 mg/kg/hora de gluconato de calcio =0,5-2 mg/kg/hora de calcio elemental
⭕️11 ampollas de gluconato de calcio=1023 mg de calcio elemental
✅Guarden este tweet.
👉 HFpEF is no longer a single disease
1️⃣ Metabolic–Obese
2️⃣ Cardiorenal
3️⃣ Hypertensive–Vascular
4️⃣ AF–Dominant
• SGLT2 i in all
• GLP-1RA in metabolic-obese phenotypes.
• Reno-cardiac modulation is central in CR profiles.
• Atrial-focused strategies may be in AF-HFpEF.
Perioperative Antithrombotic Management:
🩸Recommended pre-operative workup for patients taking anticoagulants involves stratifying both thromboembolic & bleeding risk, determining appropriate timing for medication interruption, & deciding whether bridging therapy is needed. Specific approach depends on the type of anticoagulant, renal function, and procedure-related bleeding risk.
🩸Dabigatran, interruption timing depends on renal function.
👉With normal renal function (CrCl ≥50 mL/min), stop 1-2 days before low-risk procedures and 2 days before high-risk procedures.
👉With impaired renal function (CrCl <50 mL/min), extend interruption to 3-4 days before high-risk procedures due to predominantly renal clearance.
#apixaban #rivaroxaban #Edoxaban #dabigatran #DOACs #preoperative #perioperative #Warfarin #CHA₂DS₂VASc #antithrombotic #anticoagulant #guidelines #USMLE @AAFP #medstudent #MedTwitter #Medical
No hay necesidad de tomar gasometrias arteriales.
En la cohorte más grande analizada, desarrollaron formulas para estimar los valores arteriales de pCO2, pH y bicarbonato (con correlación casi perfecta) derivado punción venosa
@Dan_Batlle
Kidney360 2026
10.34067/KID.0000001113
Although often used interchangeably, dehydration & volume depletion are not the same
#Nephpearls
📌 Dehydration refers to “loss of total body water” (leads to hypertonicity)
📌 Volume depletion refers to an ECFV deficit
👉🏼 https://t.co/qWgYgiS09p
Did you know there's a Subcutaneous (SC) rituximab (Hycela)? Its same RTX but combined w/ hyaluronidase, faster 5-7 minute injection Vs hours for IV RTX. FDA approved 2017 for Follicular Lymphoma (FL) and Diffuse Large B-cell Lymphoma (DLBCL). Give 1st dose IV, then use SC RTX.
JASN Editors’ Choice 2025: The Association of Outdoor Temperature with Severe Hyponatremia
This retrospective register-based cohort study based on the Stockholm Sodium Cohort investigated associations between ambient temperatures and severe hyponatremia.
Check it out: https://t.co/X8t7MxqRLE
Con diabetes de larga evolución, ~50% desarrollará neuropatía autonómica cardíaca, este evento se liga al deterioro de función renal y albuminuria. Aquí los mecanismos propuestos
Kidney Med 2025
10.1016/j.xkme.2025.101149