Levon

Drug Discovery | Structural Biology | WDR protein family | PI at the SGC-University of Toronto | all opinions are my own.

[Levon @HalabelianLab]

Our recent crystal structure of TREX1 in complex with a small molecule inhibitor is now available online.
#drugdiscovery #cachechallenge

https://t.co/M2pwgxxAcc

[Structural Genomics Consortium (SGC) @thesgconline]

New Blog Post 📢
Learn how @HalabelianLab utilizes AI-driven hit-finding technologies to discover small molecules targeting the WDR protein family and help elucidate the dark proteome.
#OpenScience #drugdiscovery #AI
https://t.co/gqVrm7UzEZ

[Structural Genomics Consortium (SGC) @thesgconline]

A comprehensive study by @HalabelianLab reveals the interaction of a small molecule which binds to Cbl-b and acts as an intramolecular glue locking the protein in an inactive state.
Read more: https://t.co/8KRRRdPywV

[Communications Biology @CommsBio]

Structural and biophysical characterization of a small molecule binding to Cbl-b E3 ligase reveals an intermolecular glue mechanism locking the protein in an inactive state: https://t.co/e8q9SAA9kV

@HalabelianLab @thesgconline

[Structural Genomics Consortium (SGC) @thesgconline]

WDR proteins are a large, druggable, and underexplored target class with strong disease associations.
@HalabelianLab just released several WDR structures in complex with inhibitors, which were identified using DEL-ML, in collaboration with @Relay_Tx, @XChemInc and @Google.

[Levon @HalabelianLab]

Exciting to share that our DCAF1 manuscript is now available online. It was great collaborating with the OICR team to advance this molecule into a nanomolar affinity DCAF1 ligand.

[Structural Genomics Consortium (SGC) @thesgconline]

A cool approach utilizing the DEL technology and #MachineLearning models for the discovery and cellular target engagement of the first nanomolar DCAF1 ligand. This is a great example of collaborative science between @OICR_news, @Relay_Tx and the SGC.
https://t.co/5dF8UgsaP0

[Levon @HalabelianLab]

Our recent structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor is now released. https://t.co/t4DPGZueGS
#E3ligase