Halima Aliyu

Wife, Mother & Pathologist, loving every moment!

[Halima Aliyu @Haliyuo]

@Innositol1 @InibeheEffiong Probably couldn't do it. CS no be beans.

[Halima Aliyu @Haliyuo]

@Hermosaifechef @Ofo_Chukwunonso @InibeheEffiong Same story in every sector.

[Halima Aliyu @Haliyuo]

@MRGODEMEKA @UgwumsinachiNn1 @InibeheEffiong @legalbreed01 CS is not safer. From anesthetic issues to post partum hemorrhages. The medical team and patient just have to take balanced decisions depending on the situation.

[Halima Aliyu @Haliyuo]

IAP Congress with the link embedded: IAP 2026: Fukuoka, Japan
https://t.co/Hm1y0hpZx2

[Healthnomics HMO @HealthnomicsHMO]

Choosing the right HMO plan shouldn’t be confusing.

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#HealthInsurance #HMO #Nigeria

[Halima Aliyu @Haliyuo]

IIOE Nigeria NC – AI in Education & Management: AI is no longer optional; it is shaping the future of teaching, learning, research, and higher education management. https://t.co/p2eHhJopXA

[Halima Aliyu @Haliyuo]

IIOE Nigeria NC – AI in Education & Management: AI is no longer optional; it is shaping the future of teaching, learning, research, and higher education management. This session will introduce you to AI and why it matters. https://t.co/p2eHhJoXN8

[NotasDePatologia @Notas_Patologia]

🧬 CASTLEMAN DISEASE – HYALINE-VASCULAR VARIANT (UCD-HV): WHAT EVERY PATHOLOGIST SHOULD KNOW

The unicentric hyaline-vascular variant of Castleman disease (UCD-HV) is the most common and typically benign form of this heterogeneous group of lymphoproliferative disorders. Despite its indolent nature, its morphology can mimic lymphomas and follicular dendritic cell (FDC) neoplasms, requiring diagnostic vigilance.

🔬 CLASSIC HISTOMORPHOLOGY

Atrophic lymphoid follicles with hypocellular germinal centers

Penetration of hyalinized capillaries into germinal centers (“lollipop” structures)

Expanded mantle zones with concentric layering (“onion-skin” pattern)

Marked interfollicular vascular proliferation

Occasional nuclear atypia in FDCs, though without proven malignant potential

🧪 IMMUNOHISTOCHEMISTRY
CD21, CD23, and CD35 highlight the FDC meshwork

CD20 and CD3 delineate B- and T-cell zones

Ki-67 shows low proliferative index within follicles

No aberrant expression of BCL2, CD30, or ALK

🧍‍♀️ CLINICAL DATA (Nishimura et al., Diagnostics, 2021)
Female predominance, mean age: 42 years
Most common sites: mediastinum, retroperitoneum, cervical region
Clinically silent or compressive mass effect
Complete surgical excision was curative in all cases
Excellent prognosis: 100% survival, no recurrences

🔍 DIFFERENTIAL DIAGNOSIS
Key entities to consider include:

Sclerosing follicular lymphoma: BCL2+ germinal centers and absence of prominent vascularity

Follicular dendritic cell sarcoma: cytologic atypia, mitotic activity, and aberrant immunophenotype

IgG4-related disease: dense plasmacytic infiltrate, storiform fibrosis, and increased IgG4+ cells

Reactive lymphoid hyperplasia: preserved architecture and absence of “lollipop” or “onion-skin” features

🧠 UPDATES (Vidal & Ferry, Adv Anat Pathol, 2009)

UCD-HV is not associated with IL-6 elevation or HHV-8 infection
Rare reports suggest somatic mutations in the MAPK signaling pathway
FDC atypia is considered reactive, with no clear evidence of malignancy
Clinicopathologic correlation is critical to avoid overdiagnosis

📌 Take-Home Message:

UCD-HV is a benign lymph node lesion with striking histologic patterns. Despite its indolent behavior, it can mimic neoplastic processes. Accurate recognition of its architectural features and appropriate immunohistochemistry are essential for diagnostic accuracy.

📚 Updated references:
Nishimura MF et al. Diagnostics. 2021;11(11):2008
Vidal L, Ferry JA. Adv Anat Pathol. 2009;16(4):236–246

#CastlemanDisease #HyalineVascularCastleman #SurgicalPathology #DifferentialDiagnosis #MedicalEducation #NotasDePatologia #Pathology

⚠️ Disclaimer: This content is intended for educational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment.

[Halima Aliyu @Haliyuo]

At the just concluded 49th AGSM of the WACPNg in Kano, Nigeria; themed "Healthy living: Transforming lives through healthy lifestyle choices".

[Halima Aliyu @Haliyuo]

#WACPAGSM2024

[Halima Aliyu @Haliyuo]

I will be attending the 48th WACP AGSM holding in Abuja, Nigeria. Where I will present a poster on Histopathology of Acute Appendicitis in children in Zaria.

[Halima Aliyu @Haliyuo]

@Kenny92954457 Loch Ness's monster

[Halima Aliyu @Haliyuo]

@Drweloveu This is horrible.

[Halima Aliyu @Haliyuo]

@EmirSirdam This excuse for the propagation of hate in Nigeria that some rationalise and call "vawulence" is part of the agenda to keep Nigerians in penury. When preoccupied with frivolities, the corrupt pilfer unchecked.

[Halima Aliyu @Haliyuo]

@EmirSirdam You are right that Nigeria isn't truly independent but wrong when you say that the political parties in Nigeria except the APC are independent. I didn't vote in the last 2023 elections because I realized that it didn't matter who got there. Bottom up Reform is what will work.

[Halima Aliyu @Haliyuo]

@vanguardngrnews This is a start, I believe all other doctor groups and all healthworkers should have joined the warning strike of the NARD.

[Halima Aliyu @Haliyuo]

@Kaju_Nut The Nigerian 3 to 5 year system in which you can explore all you want or hit the nail right in depending on if your University is Br. or Am. inclined

[Halima Aliyu @Haliyuo]

This is a very useful resource

Cancer Protocol Templates | College of American Pathologists https://t.co/rYxgvkt8gR

[Halima Aliyu @Haliyuo]

@lidocaine_v2 @OfficialDSSNG Who knows how much went through and now in the hands of miscreants waiting to rain terror on us at the slightest opportunity. May God enable the DSS, Police, Military, and all other security outfits to protect us.

[Halima Aliyu @Haliyuo]

@lidocaine_v2 @OfficialDSSNG Did you all see the number of guns and ammunition intercepted recently by our Custom service? May God Almighty protect all innocent Nigerians and punish all those who work to terrorise my dear country.