Hamadlab_Hopkins

Hamad lab at Hopkins studies autoimmune diseases and unconventional lymphocytes

[Hamadlab_Hopkins @HamadlabH]

Excited to share with you a new article describes members of two networks of TCRs and BCRs that represent a core set of evolutionary-conserved primordial antigen receptors that are associated with host defense and autoimmune diseases:
bioRxiv. https://t.co/k03RrqZCaZ

[Hamadlab_Hopkins @HamadlabH]

@DmitriKotov Read our reply before making judgement. Japp's paper is highly flawed- look at: conflicting data in Fig.2, inability to detect similar clones in their data (we did both for them) and their usage of 2-yr-cadavers for sorting and never verified purity.

https://t.co/fZlBhqpUfJ

[Hamadlab_Hopkins @HamadlabH]

@3DiMMUNE @albertojapp @UlrikStervbo @CellCellPress @ufdiabetes @TheHpap Not too fast - go read their paper and see how flawed it (see our reply below). A group in Colorado has already cloned x-antibody independently and produced a crystal structure of x-peptide and DQ8 peptide at 2.7 A. Link to our reply
https://t.co/fZlBhqpUfJ

[Hamadlab_Hopkins @HamadlabH]

@albertojapp @AndreyKruglov6 @CellCellPress @ufdiabetes @TheHpap What do you mean to prove a negative? You could have followed one of the six methods used to identify them in original paper. A group in colorado did that and cloned x-clonotype and generated 2.7 A complex of DQ8 and x-antigen - Your PI and other senior authors know that.

[Hamadlab_Hopkins @HamadlabH]

@albertojapp @CellCellPress @ufdiabetes @TheHpap With all due respect your paper is filled with flaws and misrepresentation. For starter: why representative dot plots in Fig2 from UPenn and UFDI are conflicting - You have given three revisions to fix it and failedd. see our reply for readers to judge:

https://t.co/fZlBhqpUfJ

[Hamadlab_Hopkins @HamadlabH]

@Nusob88 @JakobTheorell Thanks Bo. People should read our reply before making judgments and make sure what manuscript is filled with glaring flaws
https://t.co/fZlBhqpUfJ

[Hamadlab_Hopkins @HamadlabH]

@Adrien_Jolly_ Thanks Adrien - here is our reply to Japp et al. Their studies is filled with glaring flaws, including conflicting data from two sites that when we reconciled it, the results then support our conclusion
https://t.co/fZlBhqpUfJ

[Hamadlab_Hopkins @HamadlabH]

@Nusob88 Thanks Bo. I am Abdel, senior author of DEs paper. people should read our reply uncovering glaring mistakes including conflicting data from twos sites supposed to independently confirmed frequency. fixing gating shows high frequency of DEs in T1D than HC.