hamze

Leading research in catalysis 🧪, photoredox ☀️, organic synthesis ⚗️ and medicinal chemistry 💊; full Professor at the University of Paris Saclay 🎓

[hamze @HamzeInsights]

Discover our PIFA-mediated de novo synthesis of C3-arylated benzo[b]thiophenes, a versatile scaffold in medicinal chemistry! 🌟
✅ Flexible, scalable
✅ Pd-catalyzed coupling + mild cyclization
✅ Gram-scale synthesis
Cover in Org. Chem. Front.
https://t.co/eNEeEPq0PD

[OrgChemFront @OrgChemFront]

👉"PIFA-mediated cyclization of methyl(2-(1-phenylvinyl)phenyl)sulfane for the concise, flexible, and scalable de novo synthesis of C3-arylated benzo[b]thiophenes"

by Abdallah Hamze et al. @HamzeInsights
@UnivParisSaclay @psl_univ

https://t.co/aG4Cp509Mt

[hamze @HamzeInsights]

Good news! our work has received over 500 views since publication! Read it here https://t.co/Xud0J8oj32 #ViewsMilestone

[J Org Chem/Org Lett @JOC_OL]

In #JOrgChem: @HamzeInsights is excited 🚀 to share their collaboration between BioCIS, Paris Saclay, and CitCOM, Paris Cite, on visible-light synthesis of bioactive compounds! 🌟 1,1'-Diarylethylene boosts yield significantly! https://t.co/iD9pCcyco0

[hamze @HamzeInsights]

Thrilled to unveil our transition metal-free method for pyrazoloquinazolinone synthesis! 🧪 Our one-pot approach generates highly functionalized N-heterocycles with up to 92% efficiency.
https://t.co/Tkmqvc4Tjx

[Elva Hu @elvahupin]

Who is Who in the Carbene Chemistry of N-Sulfonyl Hydrazones

https://t.co/eeY2cbpPd0

[CNRS Chimie @CNRSchimie]

#chimie ⚗️ #ResultatScientifique 📕 🔎 l QAPHA, Une petite molécule qui pourrait constituer un outil thérapeutique multi-cibles pour lutter contre le #cancer du poumon par #immunothérapie

🤝 @BioCIS @CNRSIdFSud @UnivParisSaclay
➡️ https://t.co/9bivuThn4V

[hamze @HamzeInsights]

Exciting collaborative research from BioCIS UMR8076 & UMR 1015 Gustave Roussy reveals QAPHA's potential as a multitarget inhibitor, inducing immunogenic cell death & MHC-II upregulation in lung cancer cells. Promising strides in cancer treatment! 🧬https://t.co/bJ49eobTVe

[ggg @NTsapis]

Our collaborative work is on line @BioCIS @umr8612 @Pharma_UPSaclay @CNRSchimie in the French chemobiology special issue @ChemBioChem

[ChemBioChem @ChemBioChem]

Overcoming Solubility Challenges: Liposomal isoCoQ-Carbazole as a Promising Anti-Tumor Agent for Inoperable and Radiation-Insensitive cancers (D. Lamaa, A. Hamze, N. Tsapis et al.) @HamzeInsights @NTsapis #openaccess https://t.co/KMHqeen24a

[hamze @HamzeInsights]

Excited to announce our cover feature in Org. Chem. Front.! Our N-vinylazoles synthesis method led to the discovery of unexpected compounds DINQ (R= Me) and DINI (R= H), with potent cytotoxic effects on HCT-116 cells. Big thanks to all contributors!

https://t.co/fl9z2Rqctq

[OrgChemFront @OrgChemFront]

Mo-catalyzed cyclization of N-vinylindoles and skatoles: synthesis of dihydroindolo[1,2-c]-quinazolines and dihydroindolo[3,2-b]-indoles, and evaluation of their anticancer activities by Olivier Provot, Christine Tran, Abdallah Hamze et al.
@HamzeInsights
https://t.co/r5U7A0PC71

[Pharmaceuticals MDPI @Pharmaceut_MDPI]

📢#Specialissue : "#Multitargeted #Compounds: A Promising Approach in #Medicinal #Chemistry"
⏰Deadline: 25 July 2024
🎓Guest Editors : Prof. Dr. Abdallah Hamze
📖Find out more at https://t.co/sibmUimB0K

[hamze @HamzeInsights]

🧪💦 Embark on a Journey into the World of Regioselective Alkyne Hydration. 🚀 From electron-rich to -poor diarylalkynes, carbonyl-guided reactions, and more! 🌟 Stay tuned for the latest breakthroughs! 📚 https://t.co/0dLS7wdSaA

[hamze @HamzeInsights]

🔬🧪Calling all passionate minds in #OrganicChemistry and Medicinal Chemistry! 🌟 We're on the lookout for a highly motivated Post-doc to join our team and drive original research. If you're ready to make a difference, Apply today!

[hamze @HamzeInsights]

🧪🌟 We've developed a novel method for creating aza-heterocyclic compounds using N-tosylhydrazones. Our initial goal was six or seven-membered ring heterocycles, but we unexpectedly achieved high-yield bi-indole compounds. Congratulations, Xinya! 🎉👏
https://t.co/7a8tpBh5he

[hamze @HamzeInsights]

Intramolecular cyclization of N-tosylhydrazones enables the synthesis of novel NCEs with enhanced structural diversity.
Congratulations to Jun Yan on this remarkable achievement!👏 https://t.co/hqeZ9e7cEL

[Chirosynkem laboratories Pvt Ltd @chirosynkem]

New NCEs can be synthesized via Intramolecular Cyclization of tosylhydrazones
#medicinalchemistry #customsynthesis #organicsynthesis #drugdiscovery #processdevelopment https://t.co/QwQ32UtajF

[hamze @HamzeInsights]

We are looking for a Research Engineer candidate (Bac + 5 max, 1 year) for a medicinal chemistry project funded by the ANR @ Paris Saclay Univ. (CoSMIT@BioCIS) with an application in cancer (starting March 2023). Please contact us at [email protected]

[hamze @HamzeInsights]

Light‐Driven Catalyst‐Free Access to Phthalazines: Entry to Antiviral Model Drugs by Merging Domino Reactions https://t.co/pqxrXeE21n #wiley #feedly