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Why can't you use direct oral anticoagulants (DOACs) in patients with mechanical valves (MVs)?
DOACs have been one of the most important advances in my career. And yet, the presence of a MV is one of the few contraindications.
The reason highlights the unique nature of thrombus formation in those with a MV and provides insights into the evolution of human hemostasis.
Basics of Glomerulonephritis (GN). GBM is key.
All patterns can be explained by glomerular basement membrane (GBM) & type of injury.
Let’s do one at a time
CRESCENTIC GN
1. Results from breach/break of GBM (red arrow)
2. Injury is sudden & severe
Eg-ANCA & anti-GBM GN
For people pissing on ICUs
Now go & complain, why should diarrhoea require an ICU?
Call it death trap, debt trap, whatever you like.
CCM is our last & only hope.
Most satisfying medical therapy for me during the first year of Residency in Medicine is reversal of neurological deficit after thrombolysis #Neurology
Tenecteplase is real gem
Let me tell you a very important clinical pearl:
“Elevated triglyceride levels are a direct and important marker of insulin resistance at the adipose tissue”
Remember this.