Mark Haussmann

Scientist/Professor/Physiologist/Dad. @BucknellU

[Mark Haussmann @HaussmannLab]

Off twitter since pandemic, time for a comeback? A week old, but my lab in collab with @PaitzLab published a paper showing that prenatal corticosterone exposure affects stress responses later in life. Super proud of the 14 @BucknellU student coauthors! https://t.co/VrKOIywkWF

[Journal of Experimental Biology @J_Exp_Biol]

In their ECR Spotlight, @bethjrogers tells us how exercising birds burn protein as fuel in response to dehydration and that it is important for them to connect with the animals that they study by working in the field and spending time in nature

https://t.co/MJOP2pqJLH

[Samuel Hume @DrSamuelBHume]

Glucocorticoids (GC), like dexamethasone and prednisolone, are widely used in medicine, but how do they actually work?

This is really impressive work (Auger et al.), which figured it all out

There are two mechanisms: a slow, broad response, which depends on transcriptional changes by the glucocorticoid receptor (GR)

And a second, fast (but sustained) response, where GCs increase flux through macrophage TCA cycles to produce the metabolite, itaconate:
Itaconate was produced systemically in response to GCs, and quickly reduced inflammation through a range of mechanisms

Here's the most interesting bit: GCs only suppressed inflammation if the TCA cycle and itaconate were in tact, but this was mostly independent of GR's broad transcriptional response - suggesting that the TCA/itaconate pathway is predominant

A possible consequence of this: some of the side-effects of glucocorticoids in patients, like increased fat mass and type 2 diabetes, may result from GR's broad transcriptional changes...

... so if we had more precise drugs, which exploit the itaconate response but spare the GR response, this could decouple the beneficial (anti-inflammatory) effects of steroids from the negatives

Here it is: https://t.co/91IJGhgXy9

[Pankaj kapahi @kapahi_pankaj]

I'm deeply saddened to share that we have lost a remarkable friend, a wonderful mentor and esteemed colleague, Judith Campisi. Judith's impact on those around her was profound and lasting. Her legacy will continue to inspire us all. Rest in peace, Judy. You will be greatly missed

[Journal of Experimental Biology @J_Exp_Biol]

Birds have incredibly high blood sugar, but show no ill effects, so what protects them? Csongor Vágási & colleagues @EvolEcolUBB wondered if antioxidants might be the solution, but after checking over 1700 birds, it turns out that antioxidants are not
https://t.co/3aK9QNzWG3

[Benjamin Haussmann @Haussben]

Wrapping up my first SICB conference. Met so many great people and was great seeing collaborators in the @HaussmannLab! #SICB2024

[Mark Haussmann @HaussmannLab]

#SICB2024 is just about in the books. Did a little writing with my undergrad Kayla Lichtner and our collaborator @Haussben. They keep me motivated!

[Mark Haussmann @HaussmannLab]

And last but not least @Schapman789 and @Jess_Fenners had a cool poster on cold snaps, microbiome, and telomeres in tree swallows. Lucky to work with these folks. In collab with @MarenVitousek and @JennHoutz. #SICB2024 #PUI

[Mark Haussmann @HaussmannLab]

Great Friday at #SICB2024! Eva Lindner and @DziubekLab had a great poster on isolation stress, gut function, and triglycerides. Super proud of their work!

[Mark Haussmann @HaussmannLab]

Great talk about incubation temperature, heart rate, and metabolism in fence lizards by @Haussben. He’s also my nephew so it was super fun sitting in the audience and watch him present some of his Masters work @UNOmaha. #SICB2024

[Mark Haussmann @HaussmannLab]

Fireflies? Antimicrobial peptides? Bacterial inhibition? @MichelleVovsha1 poster had all three! Great work by a Bucknell undergrad at #SICB2024. #raybucknell #PUI

[Mark Haussmann @HaussmannLab]

Super proud of @nicolejosephlab, Kayla Lichtner, & Redeit Woldebirhan on their work on thermal biology and oxidative stress in fence lizards. In collab with @Haussben and Robbins lab. See it in print sometime in 2024 🤞! 2 more posters 2 go! #SICB2024 #PUI #rayBucknell

[Mark Haussmann @HaussmannLab]

Loved @jenheppner talk on maternal hormone transfer in urban environments. Cool data, excellent talk, and great art (pictured)! And she’s looking for a postdoc 👀

[Mark Haussmann @HaussmannLab]

Cool talk by @Thomas_Aj_Ryan from @MarenVitousek lab on how CORT affects social interactions in tree swallows (thanks to back of @tjgreive head for the assist). For more tree swallow work in collab with @MarenVitousek cone to our poster on Friday! #SICB2024

[Mark Haussmann @HaussmannLab]

Haussmann Lab ready for #SICB2024 !

[Mark Haussmann @HaussmannLab]

Got day 11 and 12 in of the #12WritingDays before Christmas last two days. Today working with past students Shannon McCollum (now PhD student @UMich) and Olivia Canter (now undergrad @DukeU). Writing together on Google docs with the chat feature always fun.

[Mark Haussmann @HaussmannLab]

This week did day 8 through 10 of the #12WritingDays before Christmas. Much of it has been with current & past students in the Haussmann Lab (holiday party pic. ❤️ these folks). This type of writing with young scientists is some the most fun and gratifying! #raybucknell #PUI

[Mark Haussmann @HaussmannLab]

Today was the 7th day of the #12WritingDays before Christmas! Worked with @Haussben on a paper exploring parent-offspring resource allocation in a long-lived bird species. And, no, not eagles. (Philadelphia Storm-Petrels would be a much cooler team!)

[Mark Haussmann @HaussmannLab]

@HeidingerBritt @BSSkentisland Will I see you in Seattle? Been too long and would be great to catch up!

[Mark Haussmann @HaussmannLab]

Yesterday was the 3rd day of the #12WritingDays before Christmas where I worked on a storm petrel paper (@BSSkentisland) and zoomed with collaborators Patty Jones and Bob Mauck. Today, the 4th, worked on a dataset from 12 years ago hoping to bring it to the light of day! #PUILife

[Mark Haussmann @HaussmannLab]

Yesterday was the 5th day of the #12WritingDays before Christmas & today is 6th! Yesterday joined by @MartineBotany (at culturecoffee) who was putting finishing touches on a paper. I continued to write and give comments on my student @SICB_ posters (methods figure shown)!