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Migraine science, real stories & a smarter way to track and predict your syndrome.

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Migraine-related disability includes the laundry In the SMILE cohort of 675 adults with migraine and 232 controls, men with migraine showed rising partner involvement in household tasks as their…

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Botox failed its episodic migraine trial In PRECLUDE, a phase 3 randomised trial of 775 adults with episodic migraine, neither onabotulinumtoxinA dose beat placebo on monthly migraine days…

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Nine reviews backed the nerve block. All nine had problems. An umbrella review of the greater occipital nerve block literature found nine systematic reviews supporting the procedure.

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Nearly half notice smell during an attack Pooling 58 studies and 22,299 people with migraine, 47.8% (95% CI 42.0%-53.6%) reported osmophobia.

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Four supplements actually show up in migraine guidelines:

Magnesium, riboflavin (B2), CoQ10, and feverfew. Slow, cheap, and backed by real evidence — worth a conversation with your clinician.

Have you tried any? (educational, not medical advice)

#migraine #migraineprevention

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Not every day will be a good one — and that's not you failing.

With migraine the real pattern shows up across months, not single days. One bad day doesn't undo the trend.

Zoom out. Trust the longer view.

#migraine #chronicillness

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Migraine after menopause and the stroke question Among 130,277 postmenopausal women followed for a median of 19.9 years, a migraine history was not associated with total stroke (HR 1.07.

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Migraine and IBS keep turning up together In a meta-analysis of 22 studies, people with irritable bowel syndrome had 2.09-fold odds of migraine or headache (95% CI 1.79 to 2.43).

#migraine #chronicmigraine

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The first CGRP antibody trial in children that worked In a 2026 New England Journal of Medicine trial in 234 children and adolescents aged 6–17 with episodic migraine.

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$3.9 billion of headache scans in four years Neuroimaging was ordered at 12.4% of US outpatient headache visits (95% CI 10.5–14.7) in 2007–2010 — an estimated $3.9 billion over those four years.

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A second diagnosis does not cancel the first. Pooling 23 studies (5,440 people with multiple sclerosis and 280,958 controls), 30% of people with MS met criteria for migraine (95% CI 25% to 34%).

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What 12 weeks of app biofeedback actually moved In a 279-person randomised trial, 12 weeks of daily app-based biofeedback reduced monthly migraine days by 0.9 versus 0.0 in the waitlist group…

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The thyroid signal that only just cleared the line Following 8,412 people for a mean 12.6 years, a pre-existing headache disorder was associated with a 1.21-fold risk of new-onset hypothyroidism (95%…

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Make the small comfort.

Tea. Slippers. The good blanket. Tiny rituals genuinely signal safety to a sensitive nervous system — they're not indulgent, they're regulating.

What's your go-to comfort during a rough stretch?

#migraine #chronicillness

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The migraine thalamus is short on its main antioxidant Using MEGA-PRESS spectroscopy at 3T in 76 people, left thalamic glutathione was 1.73 mM in migraine versus 2.07 mM in headache-free controls.

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Still no blood test for migraine — not even CGRP In 588 people with migraine versus 147 matched controls, median plasma CGRP was lower in the migraine group, not higher.

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A relaxation app handed out in the emergency room In a randomized trial started in New York emergency departments, 82.4% of people given a smartphone progressive-muscle-relaxation programme improved…

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Migraine costs the UK treasury £12.2 billion a year A fiscal-framework analysis estimated migraine costs the UK government £12,202 million a year.

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In pooled trials, the IV drip outscored sumatriptan In a network meta-analysis of 16 randomised trials and 1,934 patients, intravenous metoclopramide — 10 mg in nearly every trial.

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