Headache Journal

The official journal of the American Headache Society @ahsheadache | Follow also on Instagram:

[ひふみ頭痛外来 @dr_hifumi]

これは興味深い！
アトゲパント(アクイプタ®︎)による体重減少

1年間の投与で平均-2.16kg📉
約30%の患者さんで5%以上の体重減少があったそうです。

・CGRP経路が代謝や食欲に関与する可能性
・片頭痛改善により活動量が上がる可能性

などが考えられますが、機序は不明です。
薬剤の特徴として非常に興味深いですね🤔

※この研究は前向きオープンラベル延長試験のSafety outcomeとして収集された体重データの事後解析です。

📚Bond et al. Headache, 2026

[Headache Journal @HeadacheJournal]

Could #GLP1–based therapies have a role in #migraine?

A case series describes 2 patients who experienced ⬇️migraine attacks after starting #tirzepatide.

Read more:
https://t.co/7REcmpCsuL

[Headache Journal @HeadacheJournal]

Could vitamin B1 play a role in chronic #migraine?

A case–control study found ⬇️serum #thiamine levels in patients w chronic migraine, w⬇️levels also associated w⬆️#headache burden. Research is needed to clarify assocation

🔗https://t.co/I0rXqDHN17
@drprakashs @VaroonVadodaria

[Headache Journal @HeadacheJournal]

Open Access:
Could #androgen deficiency play a role in #ClusterHeadache?

A recent study found biochemical #hypogonadism in 20% of men w chronic cluster headache, & symptoms of androgen deficiency more common than in controls. More research is needed.

🔗https://t.co/T9K7RA064o

[Headache Journal @HeadacheJournal]

How do adverse childhood experiences (ACEs) & #migraine affect #pregnancy outcomes?

A recent study found both ACEs & migraine were independently assoc w ⬆️odds of adverse birth outcomes, highlighting importance of comprehensive maternal care
🔗https://t.co/reNzk9U1o3
@b_gelaye

[Headache Journal @HeadacheJournal]

Open Access:
Can #COVID19 vaccination be assoc w #ClusterHeadache?

A pharmacovigilance analysis found CH reporting signal post COVID19 vax, esp w Vaxzevria. These findings link hypotheses, not causation, & support continued monitoring

🔗https://t.co/JtDcWJPUGO
@AlexandreGerard

[Headache Journal @HeadacheJournal]

🧠Answer of the Week!

Which sleep finding was associated with migraine among patients with TMD?

Answer:
B. More mixed bruxism episodes

Read the article: DOI: 10.1111/head.14892
#Migraine #Sleep #OSA #Bruxism

[Headache Journal @HeadacheJournal]

Open Access:
📉 How does body weight change w long-term #atogepant treatment?

A 52-week phase 3 extension study found gradual weight ⬇️over time, w ~30% of participants experiencing ≥5% weight loss by 1 year.

Read more: https://t.co/Zycj8BrVEW
@dalesbond @petergoadsby et al

[American Headache Society @ahsheadache]

Applications for the 2026 AHS Resident Education Program are now open! Join us Oct. 23-25th in Los Angeles, CA.

Build your foundation in #headachemedicine.

Learn more and apply by August 9: https://t.co/L1lVPTZcL4

#HeadacheEdu

[Headache Journal @HeadacheJournal]

What happens before #migraine #pain begins?

🧠A new review explores evidence that the #hypothalamus may play a central role in the migraine #prodrome, the earliest phase of an attack.

📖 Read more: https://t.co/D2Rr8Y6rDL
Shane Root MD & @schwedtt

[American Headache Society @ahsheadache]

Missed #AHSAM 2026? It's not too late! Access session recordings from our 68th Annual Scientific Meeting — 34 countries, 46 states, 4 days of cutting-edge #headachemedicine science. Earn up to 21.25 AMA PRA Category 1 Credits® through 12/31/26. Learn more: 4oVrsyW

[Headache Journal @HeadacheJournal]

📝Question of the Week!

Read the article and check back in 2 days for the answer!

DOI: 10.1111/head.14892

#Migraine #Sleep #OSA #Bruxism

[Headache Journal @HeadacheJournal]

🧠 Answer of the Week

✅ Correct answer: C) Bilateral medial thalamus

Read the article: doi:10.1111/head.14785

#Migraine #Photophobia

[Headache Journal @HeadacheJournal]

🎥 New author interview!
Can prodrome predict #migraine head #pain onset?

We spoke w 1st author M Lacritz about her study showing #nausea, #photophobia, #phonophobia, etc were associated w ⬆️#headache odds w/in 24 hrs

Watch: https://t.co/7GBiVOrTvs
Read: https://t.co/Y1xo7mwjQR

[Headache Journal @HeadacheJournal]

Could #mirogabalin have a role in #TrigeminalNeuralgia?

In this pilot study, patients experienced short-term #pain improvement, no participants discontinued treatment because of AEs.

Larger RCTs are needed to confirm these findings.
🔗https://t.co/DmDVVxafIr

[Headache Journal @HeadacheJournal]

Do #CGRP-targeted meds⬆️#hypertension risk?

A meta-analysis found no statistically significant increase in incident hypertension, but evidence certainty was very low.

Long-term & real-world studies are still needed to better define blood pressure risk.
🔗https://t.co/uz5hdYCZuS

[Headache Journal @HeadacheJournal]

📝Question of the Week!

Read the article and check back in 2 days for the answer!

doi:10.1111/head.14785

#Migraine #Photophobia

[Headache Journal @HeadacheJournal]

What's it like to be a #college student w #migraine?

Students in this study shared challenges w academics, attendance, social activities, accommodations, access to care, & persistent misunderstandings about migraine on campus

Read more: https://t.co/Jszm3ZSmuZ
@MiaMinenMD et al

[Headache Journal @HeadacheJournal]

Are we asking the right questions in #migraine care?

This review found that #sexual dysfunction is common in both women & men w migraine, yet sexual health remains infrequently discussed in clinical practice.

Read the study: https://t.co/eqNBhuiyYp
@cimen1977 et al

[Headache Journal @HeadacheJournal]

Open Access:
New #headache + vision loss isn't always #migraine

This case report follows a patient whose eye symptoms were traced to lung #adenocarcinoma metastasis

🔍Funduscopic examination can be diagnosis-changing
🔗https://t.co/28b2NiLsKc
@laurel_tanke @NCherayil et al