It was an honor to be the moderator for this session. pCO2 gap is one of the parameters I frequently use in my practice. Thank you Dr. Teboul for sharing your expertise with us.
Jean Louis Teboul explaining the importance of pCO2 Gap at Philippines Heart Centre postgraduate course
If patient in shock and ScvO2 is high then don’t give fluids unless pCO2 gap is abnormal as an increase in CO will not improve tissue perfusion
Now that we know the formulas we have to reconcile math with science.
BP = CO X SVR
CO = SV X HR
To ⬇️BP, we have to ⬇️CO &/or SVR.
To ⬇️CO we need to ⬇️SV &/or HR.
To ⬇️ SVR we need vasodilators.
Thus these meds work to ⬇️BP:
Beta blockers ⬇️HR
CCBs ⬇️ SVR by vasodilation
🫀 formulas you need to know by 🫀 part 4
Fick principle
CO = VO2 / CaO2-CvO2
VO2 = BSA X 125
CaO2 = Hgb x 1.36 x arterial O2 saturation
CvO2 = Hgb x 1.36 x venous O2 saturation
VO2 - oxygen consumption
CaO2 - arterial oxygen concentration
CvO2 - venous oxygen concentration
🫀 formulas you need to know by 🫀 part 1.
Blood pressure (BP) = CO x SVR
Systemic Vascular Resistance (SVR) = MAP - CVP / CO
Cardiac output (CO) = SV x heart rate
Mean arterial pressure (MAP) = SBP + (2 x DPB) / 3
Stroke Volume (SV) = EDV - ESV
According to Transfusion Requirements in Cardiac Surgery III (TRICS III) trial:
patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive strategy (<7.5 g/dL) regarding red-cell transfusion was noninferior to a liberal strategy (<9.5 g/dL).